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Interaction forces between soft magnetic particles in uniform and non-uniform magnetic fields

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Acta Mechanica Sinica 2010年第6期26卷 921-929页

作者： ayyoub Mehdizadeh James F.Klausner Nima Rahmatian Department of Mechanical and Aerospace Engineering University of FloridaP.O.Box 116300GainesvilleFL 32611-6300USA

The influence of the magnetization of a soft magnetic sphere on the surrounding magnetic field is measured and *** interaction force between two soft magnetic particles is directly measured using an ultra precision load sensor in uniform and non-uniform magnetic fields. The interaction force largely follows an inverse fourth power law as a function of separation distance between particle centers. At small distances,the effect of magnetization of one particle on the magnetization of its adjacent particle causes the attractive（repulsive） force to be larger（smaller） than that predicted by the inverse fourth power *** theoretical prediction based on a modified dipole model,that takes into account the coupling effect of the magnetization among soft magnetic particles,gives excellent agreement with the measured force in a uniform magnetic *** interaction force under a non-uniform applied magnetic field can be reasonably predicted using the dipole-dipole interaction model when the local magnetic field is used to determine the magnetization.

关键词： Magnetic force Magnetic charge model Magnetic dipole model Soft magnetic particle

Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders:a randomized clinical trial

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World Journal of Pediatrics 2016年第4期12卷 436-442页

作者： Faezeh Ghalichi Jamal Ghaemmaghami ayyoub Malek Alireza Ostadrahimi Nutrition Research Center Faculty of Nutrition and Food SciencesBiochemistry and Diet TherapyTabriz University of Medical SciencesTabrizIran Faculty of Nutrition and Food Sciences Biochemistry and Diet TherapyTabriz University of Medical SciencesTabrizIran Clinical Psychiatry Research Center Department of PsychiatryTabriz University of Medical SciencesTabrizIran Department of Biochemistry and Diet Therapy Tabriz University of Medical SciencesTabrizIran

Background:Genetic and environmental factors are both responsible for the etiology of autism spectrum disorders(ASD).Although epidemiological studies have been conducted to clarify the association between restriction diets and ASD,the conclusion remains *** study was undertaken to investigate the effect of gluten free diet(GFD)on gastrointestinal symptoms and behavioral indices in children with ***:In this randomized clinical trial,80 children diagnosed with ASD by the Autism Diagnostic Interview-Revised(ADI-R)were assigned into GFD(n=40)and regular diet(RD)(n=40)groups for 6 *** the beginning and end of the intervention,the ROMEШquestionnaire for evaluating gastrointestinal symptoms and Gilliam Autism Rating Scale 2 questionnaire(GARS-2)for assessing psychometric properties were ***:Of the 80 children,53.9%had gastrointestinal *** the GFD group,the prevalence of gastrointestinal symptoms decreased significantly(P<0.05)after intake of GFD(40.57%vs.17.10%)but increased insignificantly in the RD group(42.45%vs.44.05%).GFD intervention resulted in a significant decrease in behavioral disorders(80.03±14.07 vs.75.82±15.37,P<0.05)but an insignificant increase in the RD group(79.92±15.49 vs.80.92±16.24).Conclusion:This study suggested that GFD may be effective in controlling gastrointestinal symptoms and ASD behaviors.

关键词： autism behavior disorders/problems gastrointestinal system gluten free diet

Quality of sleep and its determinants among people with type 2 diabetes mellitus in Northwest of Iran

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World Journal of Diabetes 2017年第7期8卷 358-364页

作者： Seyed Morteza Shamshirgaran Jafar Ataei ayyoub Malek Manochehr Iranparvar-Alamdari Nayyereh Aminisani Department of Statistics and Epidemiology School of Health Sciences Tabriz University of Medical Sciences Injury Epidemiology Prevention Research Center Tabriz University of Medical Sciences Khalkhal Health Center School of Khalkhal Medical Sciences Ardabil University of Medical Sciences Research Center of Psychiatry and Behavioral Sciences Tabriz University of Medical Sciences Department of Internal Medicine School of Medicine Ardabil University of Medical Sciences

AIM To examine sleep quality and its determinants among people with type 2 diabetes mellitus(T2DM).METHODS This is a cross-sectional study conducted among diabetic patients referring to Ardabil diabetes clinic in Northwest of Iran. Information on sleep quality was collected using Pittsburg Sleep Quality Index(PSQI). A questionnaire was used to collect data on sociodemographic lifestyle factors and psychological distress. This questionnaire was completed through an interview, and clinical information was extracted from patient's record. Data analysis was done using SPSS software version 23 and univariate andmultivariate *** Study participants consist of 256 people with T2 DM the majority of whom were women(70%), and mean age of participants was 54.06 ± 9.09. The mean of total score of PSQI was 5.56 ± 3.34. Relative to younger age group, the middle-aged people with T2 DM were twice more likely to be poor sleeper; the adjusted OR was 2.03(95%CI: 1.01-4.08); and those with longer duration of diabetes were about 1.8 times more likely to report poor quality of sleep(ORadj = 1.77, 95%CI: 0.98-3.13). Participants with cholesterol level ≥ 240 mg/dL were about twice more likely to be poor sleeper(ORadj = 1.99, 95%CI: 1.01-3.94). The odds of being poor sleeper increased as the level of distress increased(1.84-4.09).CONCLUSION As indicated by the results of the present study, some factors including age, duration of disease, psychological distress and high level of cholesterol were independently associated with poor sleep quality.

关键词： Type 2 diabetes mellitus Lifestyle Pittsburg Sleep Quality Index Hypercholesterolemia Psychological distress

Stem Cells and Exosomes-associated Therapeutic Applications

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Journal of Clinical and Nursing Research 2024年第6期8卷 232-246页

作者： Usama Ahmed Muhammad Abubakar Rooma ayyoub Baqaur Rehman Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan

Exosomes are extracellular vesicles with sizes from 30 to 150 nm in diameter and modulate the transport of multiple intracellular biological molecules including proteins,nucleic acids,lipids,and *** regulate a large number of cells and are involved in different pathological and physiological activities including carcinogenesis,viral infection,cell-cell communication and immune responses as *** cell-derived exosomes carry many benefits over simple stem cells in the form of easy access,freedom from tumourigenic capabilities,non-infusion toxicity,effortless preservation,and *** have almost the same properties and perform functions effectively in the same way as their parental cells do like adult stem cells and embryonic stem *** to their pluripotent or multipotent abilities,stem cells(SCs)transform into several types of *** addition to other secretions,SC also give exosomes,which in turn shows therapeutic significance for many disorders,including cancer,diabetes mellitus,skin allergies and regenerative *** originating from mesenchymal stem cells(MSCs)have miRNAs,lipids,and proteins that trigger diabetes and cancer situations in *** from SCs(sc-exos)are preferred to SC as there are fewer side effects and other challenges,including effectiveness,drug delivery,lower immunogenicity and *** the current review,we summarize the data from the last 5 years'articles about exosomes and stem cell-derived microvesicles for the therapeutic potential of various diseases such as cancer,Alzheimer's disease,diabetes,and Parkinson's disease with clinical challenges and future aspects.

关键词： Stem cells Exosomes Therapeutic Cancer Parkinson Diabetes

Advancing Cancer Stem Cell-Targeted Therapeutic Applications

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Proceedings of Anticancer Research 2024年第5期8卷 32-45页

作者： Muhammad Abubakar Rooma ayyoub Baqaur Rehman Muhammad Zubair Usama Ahmed Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan 2Institute of Biological SciencesKhwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan 3Department of MedicineSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China

Cancer stem cells(CSCs),first identified in blood cancers,are increasingly recognized as significant biomarkers and targets in tumor therapy due to their metastatic potential and role in cancer *** research has demonstrated the dedication of scientists in targeting CSCs to explore novel therapeutic *** types of cancer exhibit metastasis,heterogeneity,and resistance to treatment,all of which are influenced by *** cells utilize various transcription factors and signaling pathways to carry out these *** identifying and understanding these pathways,new therapeutic breakthroughs can be ***,targeting cancer stem cells holds great potential and importance in cancer ***,CSCs offer promising avenues for treating otherwise incurable ***,targeting CSCs presents challenges such as immunological rejection and disease *** research into CSCs may reveal new insights in the fight against cancer and ultimately improve human *** review explores the roles of CSCs in cancer development and treatment,aiming to uncover new therapeutic approaches.

关键词： Cancer stem cells Cancer Therapy

Analysis of Genetic Alterations in TP53 Gene in Breast Cancer - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 25-35页

作者： Baqaur Rehman Muhammad Abubakar Muhammad Naeem Kiani Rooma ayyoub Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China

Tumor protein p53 (TP53) mediates DNA repair and cell proliferation in growing cells. The TP53 gene is a tumor suppressor that regulates the expression of target genes in response to multiple cellular stress factors. Key target genes are involved in crucial cellular events such as DNA repair, cell cycle regulation, apoptosis, metabolism, and senescence. TP53 genetic variants and the activity of the wild-type p53 protein (WT-p53) have been linked to a wide range of tumorigenesis. Various genetic and epigenetic alterations, including germline and somatic mutations, loss of heterozygosity, and DNA methylation, can alter TP53 activity, potentially resulting in cancer initiation and progression. This study was designed to screen three reported mutations in the DNA-binding domain of the p53 protein in breast cancer, to evaluate the relative susceptibility and risk associated with breast cancer in the local population. Genomic DNA was isolated from 30 breast tumor tissues along with controls. Tetra and Tri ARMS PCR were performed to detect mutations in the TP53 coding region. For SNPs c.637C>T and c.733C>T, all analyzed cases were homozygous for the wild-type allele ‘C,’ while for SNP c.745A>G, all cases were homozygous for the wild-type allele ‘A.’ These results indicate no relevance of these three SNPs to cancer progression in our study cohort. Additionally, the findings from whole exon sequencing will help to predict more precise outcomes and assess the importance of TP53 gene mutations in breast cancer patients.

关键词： Breast cancer p53 Gene expression Mutation SNPs

Exploring Novel Therapeutic Breakthroughs for Cancers:Potential Roles of miRNAs

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Proceedings of Anticancer Research 2024年第5期8卷 11-24页

作者： Muhammad Abubakar Rooma ayyoub Baqaur Rehman Muhammad Naeem Kiani Usama Ahmed Jawaria Farooq Areeb Anwar Usmani Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060PR China Department of Zoology The Government Sadiq College Women University BahawalpurPakistan Research Coordinator Department of SurgeryAga Khan University and Hospital KarachiPakistan

MicroRNAs(miRNAs)are small non-coding RNAs,19-25 nucleotides in length,that regulate gene *** are involved in various cellular,biological,and pathological activities,including the development and progression of malignant *** studies have highlighted the significant roles of miRNA deregulation in various cancer types,involving critical pathways such as gene deletions and amplifications,abnormal epigenetic changes,and dysfunctional miRNA regulatory *** can function both as oncogenes and tumor suppressor genes in different *** cancer hallmarks are associated with deregulated miRNAs,including resistance to cell death,metastasis,sustained proliferative signaling,promotion of angiogenesis,and the suppression of growth *** research has demonstrated that miRNAs contribute to drug resistance in tumor cells by targeting genes linked to drug resistance or by influencing genes that regulate the cell cycle,apoptosis,and proliferation.A single miRNA often has tissue-specific regulatory functions and can affect multiple *** miRNA types have been identified as potential biomarkers for tumor diagnosis and critical targets for novel therapeutic *** review aims to explore the role of miRNAs in cancer progression,metastasis,and potential therapeutic interventions.

关键词： MicroRNAs Cancer Treatment