Exploring Novel Therapeutic Breakthroughs for Cancers:Potential Roles of miRNAs

作     者：Muhammad Abubakar Rooma Ayyoub Baqaur Rehman Muhammad Naeem Kiani Usama Ahmed Jawaria Farooq Areeb Anwar Usmani 

作者机构：Department of BiosciencesCOMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound ImagingSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of MedicineSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060PR China Department of ZoologyThe Government Sadiq College Women University BahawalpurPakistan Research CoordinatorDepartment of SurgeryAga Khan University and Hospital KarachiPakistan 

出 版 物：《Proceedings of Anticancer Research》 (抗癌研究)

年 卷 期：2024年第8卷第5期

页      面：11-24页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：MicroRNAs Cancer Treatment 

摘      要：MicroRNAs(miRNAs)are small non-coding RNAs,19-25 nucleotides in length,that regulate gene *** are involved in various cellular,biological,and pathological activities,including the development and progression of malignant *** studies have highlighted the significant roles of miRNA deregulation in various cancer types,involving critical pathways such as gene deletions and amplifications,abnormal epigenetic changes,and dysfunctional miRNA regulatory *** can function both as oncogenes and tumor suppressor genes in different *** cancer hallmarks are associated with deregulated miRNAs,including resistance to cell death,metastasis,sustained proliferative signaling,promotion of angiogenesis,and the suppression of growth *** research has demonstrated that miRNAs contribute to drug resistance in tumor cells by targeting genes linked to drug resistance or by influencing genes that regulate the cell cycle,apoptosis,and proliferation.A single miRNA often has tissue-specific regulatory functions and can affect multiple *** miRNA types have been identified as potential biomarkers for tumor diagnosis and critical targets for novel therapeutic *** review aims to explore the role of miRNAs in cancer progression,metastasis,and potential therapeutic interventions.