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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor khosravi Farzad Dastaviz Mehdi Sheikh Arabi ayyoob khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor khosravi ayyoob khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Preparation of CO2 selective composite membranes using Pebax/CuBTC/PEG-ran-PPG ternary system

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Journal of Energy Chemistry 2017年第3期26卷 530-539页

作者： Tayebeh khosravi Mohammadreza Omidkhah Faculty of Chemical Engineering Tarbiat Modares UniversityP.O.Box 14115-143TehranIran

Three phase PebaxMH 1657/PEG-ran-PPG/CuBTC（polymer/liquid/solid） was successfully deposited as a selective layer on a porous Polysulfone（PSF） support. In fact, the beneficial properties of PEG（high selectivity） with those of PPG（high permeability, amorphous） have been combined with superior properties of mixed matrix membrane（MMMs）. The membranes were characterized by DSC, TGA and SEM, while CuBTC was characterized by COand CHadsorption test. Statistically based experimental design（central composite design, CCD） was applied to analyze and optimize the effect of PEG-ran-PPG（10–50 wt%） and CuBTC（0–20 wt%） mass contents on the COpermeance and CO/CHideal selectivity. Based on the regression coefficients of the obtained models, the COpermeance was notably influenced by PEG-ran-PPG,while CuBTC has the most significant effect on the CO/CHideal selectivity. Under the optimum conditions（PEG-ran-PPG: 32.76 wt% and CuBTC: 20 wt%）, nearly 620% increase in the COpermeance and43% enhancement in the CO/CHideal selectivity was observed compared to the neat Pebax. The effect of pressure（3, 9 and 15 bar） on the pure and mixed gas separation performance of the composite membranes was also investigated. The high solubility of COin the membranes resulted in the enhancement of COpermeability with increase in gas pressure.

关键词： CO2 separation Pebax Composite membrane CuBTC PEG-ran-PPG

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Mobile Multimedia Computing in Cyber-Physical Surveillance Services Through UAV-Borne Video-SAR:A Taxonomy of Intelligent Data Processing for IoMT-Enabled Radar Sensor Networks

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Tsinghua Science and Technology 2022年第2期27卷 288-302页

作者： Mohammad R.khosravi Sadegh Samadi Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz 313-71555Iran

This study investigates the different aspects of multimedia computing in Video Synthetic Aperture Radar(Video-SAR)as a new mode of radar imaging for real-time remote sensing and *** research also considers new suggestions in the systematic design,research taxonomy,and future trends of radar data *** the conventional modes of SAR imaging,Video-SAR can generate video sequences to obtain online monitoring and green surveillance throughout the day and night(regardless of light sources)in all ***,an introduction to Video-SAR is ***,some specific properties of this imaging mode are ***,this research covers one of the most important aspects of the Video-SAR systems,namely,the systematic design requirements,and also some new types of visual distortions which are different from the distortions,artifacts and noises observed in the conventional imaging *** addition,some topics on the general features and high-performance computing of Video-SAR towards radar communications through Unmanned Aerial Vehicle(UAV)platforms,Internet of Multimedia Things(IoMT),Video-SAR data processing issues,and real-world applications are investigated.

关键词： Video Synthetic Aperture Radar(Video-SAR)imaging radar networks radar image processing high-performance computing Internet of Multimedia Things(IoMT) cybersecurity

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Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

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Frontiers of Structural and Civil Engineering 2023年第4期17卷 566-583页

作者： Ramin VALI Saeed khosravi Majid BEYGI Department of Civil Engineering Technical and Vocational UniversityTehran ***Iran Department of Mining Engineering Shahid Bahonar University of KermanKerman ***Iran Department of Civil Engineering Yazd UniversityYazd ***Iran

The analysis of the bearing capacity of strip footings sited near an excavation is critical in *** this study,the effects of the geometrical features of the excavation and the soil strength properties on the seismic bearing capacity of a strip footing resting on an excavation were evaluated using the lower and upper bounds of the finite element limit analysis *** effects of the setback distance ratio(L/B),excavation height ratio(H/B),soil strength heterogeneity(kB/cu),and horizontal earthquake coefficient(kh)were *** charts and tables were produced to clarify the relationship between the undrained seismic bearing capacity and the selected parameters.

关键词： excavation finite element limit analysis heterogeneous soil strip footing undrained bearing capacity

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Evaluation of restoration success in arid rangelands of Iran based on the variation of ecosystem services

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Journal of Arid Land 2023年第11期15卷 1290-1314页

作者： Mohsen SHARAFATMANDRAD Azam khosravi MASHIZI Department of Ecological Engineering Faculty of Natural ResourcesUniversity of JiroftJiroft ***Iran

The plantation of non-native species is one of the most expensive ecological restoration measures in arid and semi-arid areas,while its impacts on local communities are largely *** study assessed the rate of change and the dynamic degree of the economic values of ecosystem services related to local conservation(water yield,stocking rate and aesthetic value)and preserving the future(carbon sequestration,soil protection,soil stability and habitat provision)to determine the restoration success of the plantation of non-native species Haloxylon ammodendron(***.)Bunge ex Fenzl(15-and 30-year-old)in parts of arid rangelands of Bardsir region,Kerman Province,*** investigated the impacts of the two plantations on the seven ecosystem services and ecosystem structures(horizontal and vertical structures,vegetation composition and species diversity)based on field sampling and measurements at four sampling sites(i.e.,control,degraded,and 15-and 30-year-old plantation sites)in spring and summer of *** restoration success of the plantation of non-native species was then examined by assessing the rate of change and the dynamic degree of the total economic value of all ecosystem services as well as the rate of change and the dynamic degree of the economic values of ecosystem services for the two groups(local conservation and preserving the future).Although the plantation of non-native species *** enormously improved the vertical and horizontal structures of ecosystems,it failed to increase species diversity and richness ***,despite the plantation of non-native species *** had significantly increased the economic values of all ecosystem services,it was only quite successful in restoring carbon *** analysis showed that plantation age had a significant impact on restoration success directly and indirectly(through changing ecosystem structures and services).The dynamic degree of the economic values of ecosystem services r

关键词： Haloxylon ammodendron restoration success ecosystem services ecosystem structures arid ecosystems path analysis Iran

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Autonomous fault-diagnosis and decision-making algorithm for determining faulty nodes in distributed wireless networks

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 885-896页

作者： Adel khosravi Yousef SEIFI KAVIAN Electrical Engineering Department Faculty of Engineering Shahid Chamran University of Ahvaz

In this paper, we address fault-diagnosis agreement(FDA) problems in distributed wireless networks(DWNs) with arbitrary fallible nodes and healthy access points. We propose a new algorithm to reach an agreement among fault-free members about the faulty ones. The algorithm is designed for fully connected DWN and can also be easily adapted to partially connected networks. Our contribution is to reduce the bit complexity of the Byzantine agreement process by detecting the same list of faulty units in all fault-free members. Therefore, the malicious units can be removed from other consensus processes. Also, each healthy unit detects a local list of malicious units, which results in lower packet transmissions in the network. Our proposed algorithm solves FDA problems in 2t+1 rounds of packet transmissions, and the bit complexity in each wireless node is O(nt+1).

关键词： Fault diagnosis Decision making Byzantine agreement Distributed wireless networks Consensus

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Plant community dynamics in arid lands: the role of desert ants

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Journal of Arid Land 2021年第3期13卷 303-316页

作者： Mohsen SHARAFATMANDRAD Azam khosravi MASHIZI Department of Ecological Engineering Faculty of Natural ResourcesUniversity of JiroftJiroft ***Iran

Ants (Formicidae, Hymenoptera) play an important role in seed bank, seedling establishment andplant composition of arid ecosystems. Thus, knowing plant-ant interaction provides useful information formanagers to design restoration and conservation plans. In this study, the roles of desert harvester ants (Messorintermedius and Messor melancholicus) and scavenger ants (Cataglyphis nodus and Lepisiota semenovi) on plantcommunities were investigated in arid ecosystems of southeastern Iran. Two vegetation types weredistinguished in the study area and the nest density of ant species was determined. Furthermore, plantcomposition and soil seed bank were estimated at different distances from the ant nests. Results showed thatthe density of M. intermedius and M. melancholicus nests was higher in dwarf shrub-shrub vegetation type and thedensity of C. nodus and L. semenovi nests was higher in dwarf shrub vegetation type. The harvester and scavengerants had enhanced the seed bank to 55% and 70%, respectively. Therefore, the role of scavenger ants on theplant communities' seed bank was greater than that of harvester ants. Although the scavenger ants were moreinfluential on the annuals and the invasive plant species, the radius impact of the harvester ants on theperennials was greater, i.e., a positive interaction existed between the perennial plants and the harvester ants. *** and L. semenovi played an important role in enhancing the ecosystem's potential for restoration throughestablishment of pioneer species in early stage of succession. The activity of M. intermedius is crucial for thedevelopment and maintenance of climax plant communities in arid ecosystems through assisting the plantspecies' establishment in late stage of succession. It is essential to preserve the diversity of these key ant speciesfor the maintenance and sustainability of shrubs in arid ecosystems.

关键词： ants ecological succession ecosystem rangelands shrubs vegetation

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Green,mild and efficient bromination of aromatic compounds by HBr promoted by trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane in water as a solvent

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Chinese Chemical Letters 2012年第4期23卷 387-390页

作者： Kaveh khosravi Samira Kazemi Department of Chemistry Faculty of ScienceUniversity of Arak Department of Chemistry Shahr-e-Rey branchIslamic Azad University

A combination of HBr and trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane as anew and powerful oxidant was found effective for facile brotnination of different aromatic compounds at room temperature in water as a green *** reaction conditions,high selectivity and yield,high reaction rate and non-toxicity are some of the major advantages of this synthetic protocol.

关键词： Trans-3 5-dihydroperoxy-3 5-dimethyl-1 2-dioxolane HBr Bromination Anilines Phenoles

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CHARACTEIZATIONS OF WOVENT g-FRAMES AND WEAVING g-FRAMES IN HILBERT SPACESS AND C^(*)-MODULES

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Acta Mathematica Scientia 2023年第6期43卷 2471-2482页

作者： Amir khosravi Mohammad Reza FARMANI Faculty of Mathematical Sciences and Computer Kharazmi University599 Taleghani Ave.Tehran 15618Iran

In this paper,using Parseval frames we generalize Sun’s results to g-frames in Hilbert C^(*)-***,for g-frames in Hilbert spaces,we present some characterizations in terms of a family of frames,not only for orthonormal ***,we have a note about a comment and a relation in the proof of Proposition 5.3 in[*** et al.,On weaving g-frames for Hilbert spaces,Complex Analysis and Operator Theory,2020].Finally,we have some results for g-Riesz bases,woven and P-woven g-frames.

关键词： g-frame fusion frame woven frame Riesz basis g-Riesz basis

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