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Studies from Hibiscus sabdariffa(Hibiscus)Plant for Blood Cholesterol Levels Reduction

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American Journal of Plant Sciences 2019年第4期10卷 497-511页

作者： Fermín Aguirre-García Lourdes yánez-López miguel A.Armella jose R.Verde Biotechnology Deptarment Universidad Autónoma MetropolitanaMéxico CityMéxico Biology Deptarment Universidad Autónoma MetropolitanaMéxico CityMéxico

The species Hibiscus sabdadariffa L. is originally from Africa. It has been distributed all over the world as an ornamental plant and it is consumed in several ways as infusion, salad dressings, marmalades, etc. However, its medical benefits are rarely studied. In this paper we present results from a clinical assay demonstrating the influence of hibiscus effects, presented as dry extracts in gel caps, on a general blood lipidic profile (LDL and HDL Cholesterol and triglycerides). We recruited 20 volunteers, 45 to 64 years old with the compromise of not changing food habits. They were divided into two groups;one of them received two 500 mg hibiscus dry gel caps treatment, three times a day for two months and the other group received same doses of placebo (Fructose) for the same period. Results showed a blood lipidic concentration reduction in those patients under hibiscus treatment statistically different (p 0.05) as compared to control patients.

关键词： medicinal Plants Jamaica Cholesterol Control Triglycerides

Variational study of bifurcations in von Karman equations

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Frontiers of mathematics in China 2019年第3期14卷 567-590页

作者： Rongrong jin Guangcun LU Laboratory of mathematics and Complex Systems (ministry of Education of China) School of Mathematical Sciences Beijing Normal University Beijing 100875 China

For a class of nonlinear elliptic boundary value problems including the von Karman equations considered by D. m. Due, n. L. Luc, L. Q. nam, and T. T. Tuyen [nonlinear Anal., 2003, 55: 951-968], we give a new proof of a corresponding theorem of three solutions via morse theory instead of topological degree theory. Several bifurcation results for this class of boundary value problems are also obtained with morse theory methods. In addition, for the von Karman equations studied by A. Borisovich and J. Janczewska [Abstr. Appl. Anal., 2005, 8: 889-899], we prove a few of bifurcation results under Dirichlet boundary conditions based on the second named author’s recent work about parameterized splitting theorems and bifurcations for potential operators.

关键词： morse theory von Karman equations bifurcation

First report of L1014F kdr mutation in Culex quinquefasciatus in mexico

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Insect Science 2016年第6期23卷 829-834页

作者： Gustavo Ponce Iram P. Sanchez Selene m. Garcia jose m. Torrado Saul Lozano-Fuentes Beatriz Lopez-monroy Adriana E. Flores Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo Leon A v. Universidad sin Cd. Universitaria San Nicolas de los GarzaN.L. 66455 Mexico Department of microbiology Immunology and Pathology Colorado State University Fort Collins CO USA

The L1014F mutation in the voltage-sodium channel gene has been associated with resistance to DDT and pyrethroids in various arthropod species including mosquitoes. We determined the frequency of the L1014F kdr mutation in 16 field populations of Culex quinquefasciatus from northeastern mexico collected between 2008 and 2013. The L1014F was present in all populations analyzed with the lowest frequency （3.33%） corresponding to the population from monclova collected in 2012, and the highest frequency （63.63%） from the monterrey population collected in 2012. The presence of a kdr mutation in populations of Cx. quinquefasciatus from northeastern mexico provides evidence ofpyrethroid resistance. This requires a special attention, considering that pyrethroid-based insecticides are commonly used in vector-control campaigns, especially against Aedes aegypti （L.）.

关键词： Culex quinquefasciatus insecticide resistance kdr L 1014F mutation

Culture mixed-Sex and monosex of Tilapia in Ponds in mexico City

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Agricultural Sciences 2015年第2期6卷 187-194页

作者： jose Luis Gomez-márquez Bertha Pena-mendoza maria del Carmen Alejo-Plata jose Luis Guzmán-Santiago Laboratorio de Limnología Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoMéxicoD.F.México Campus Puerto Angel Universidad del MarCiudad UniversitariaPuertoángelMéxico

In this study, the growth of Oreochromis niloticus both mixed sex and males sexually reversed were analyzed in concrete ponds in the FES Zaragoza, UnAm, under the environmental conditions of the mexico City. The experiment was carried from may to november 2013, in two concrete ponds of 50 m2. Similar feeding regime and stocking density of fish were maintained for the culture systems. Different growth parameters like body weight, length, daily weight gain (DWG), specific growth rate (SGR), feed conversion rate (FCR), Fulton’s condition index (K) and survival were analyzed during six months culture period. It was found that culture with monosex males tilapias yielded the highest weight, length, DWG and SGR compared to mixed sex populations tilapias. Water quality was monitored along the experiment. Based on the results, there were statistically significant differences in size (W = 20942.5, p 5 mg/L), warm water (>20°C), productive (3) and slightly basic (pH > 8). Acceptable growth of fish and a yield of 3 ton/ha/6 months were obtained in both two ponds;therefore, the culture of tilapia under conditions of mexico City was recommended.

关键词： Tilapia Culture Growth Survival mexico City

Curcuma wenyujin y. H. Chen et C. Ling n-Butyl Alcohol Extract Inhibits AGS Cell Helicobacter pyloriCagA+VacA+ Promoted Invasiveness by Down-Regulating Caudal Type Homeobox Transcription Factor and Claudin-2 Expression

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Chinese Journal of Integrative medicine 2020年第2期26卷 122-129页

作者： jin Hai-feng DAI jin-feng mEnG Li-na LU Bin Department of Gastrointerology the First Affiliated Hospital of Zhejiang Chinese Medical University

Objective:To investigate the effects and possible mechanisms of action of Curcuma wenyujin *** et *** n-Butyl alcohol extract(CWnAE)on repression of human gastric cancer(GC)AGS cell invasion induced by co-culturing with Helicobacter pylori(HP).methods:AGS cells were cultured with HP of positive or negative cytotoxin-associated gene A(Cag A)and vacuolating cytotoxin gene A(Vac A)expression(Cag A+/-or Vac A+/-)and divided into 5 *** A was cultured without HP as a control,Group B with HPCagA+VacA+,Group C with HPCagA-VacA-,Group D with HPCagA+VacA+and CWnAE,and Group E with HPCag A-Vac Aand ***-tetrazolium bromide(mTT)and tumor invasion assays,examinations of morphology and ultramicroscopic structures,quantitative real-time polymerase chain reaction and Western blots were performed to measure the effects and uncover the mechanisms behind these effects of HPCagA+VacA+and CWnAE on the epithelial-mesenchymal transition(EmT)of AGS ***:The 10%inhibitory concentration of CWnAE against AGS cells after a 48 h incubation was 19.73±1.30μg/m *** AGS cells were elongated after co-culturing with HPCagA+VacA+than after culturing with HPCagA-VacA-.In tumor invasion assays,HPCagA+VacA+significantly enhanced the invasiveness of AGS cells compared to the other experimental groups(all P valuend this effect was inhibited by *** with CWnAE normalized tight junctions and reduced the number of pseudopodia of AGS cells co-cultured with HPCagA+VacA+.HPCagA+VacA+up-regulated zincfinger ebox binding homeobox 1(ZEB1)in AGS cells after co-culturing for 24 *** of caudal type homeobox transcription factor(CDX-2)and claudin-2 was significantly increased by HPCagA+VacA+(Pnot by HPCagA-VacA-.Conclusions:HPCagA+VacA+promoted the invasiveness of AGS cells through up-regulation of ZEB1 transcription and claudin-2 and CDX-2 *** inhibited these effects of HPCagA+VacA+on AGS cells by down-regulating ZE

关键词： Helicobacter pylori gastric cancer AGS zinefinger ebox binding homeobox 1 caudal type homeobox transcription factor claudin・2 Chinese medicine

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nanostructured biohybrid material with wide-ranging antiviral action

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nano Research 2023年第8期16卷 11455-11463页

作者： noelia Losada-Garcia Angela Vazquez-Calvo David Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami jose m.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBERehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCunPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期 152-160页

作者： Zhi-Jun Xie Jia-Lin Li Ling Gong Xiang-Li Zhong Hong-Jia Song jin-Bin Wang national-Provincial Laboratory of Special Function Thin Film materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·n-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

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mapReduce-based entity matching with multiple blocking functions

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Frontiers of Computer Science 2017年第5期11卷 895-911页

作者： Cheqing jin Jie CHEn Huiping LIU Institute for Data Science and Engineering School of Computer Science and Software Engineering East China Normal University Shanghai 200062 China

Entity matching that aims at finding some records belonging to the same real-world objects has been studied for decades. In order to avoid verifying every pair of records in a massive data set, a common method, known as the blocking- based method, tends to select a small proportion of record pairs for verification with a far lower cost than O（n2）, where n is the size of the data set. Furthermore, executing multiple blocking functions independently is critical since much more matching records can be found in this way, so that the quality of the query result can be improved significantly. It is popular to use the mapReduce （mR） framework to improve the performance and the scalability of some compli- cated queries by running a lot of map （/reduce） tasks in parallel. However, entity matching upon the mapReduce frame- work is non-trivial due to two inevitable challenges： load balancing and pair deduplication. In this paper, we propose a novel solution, called m rEin, to handle these challenges with the support of multiple blocking functions. Although the existing work can deal with load balancing and pair deduplication respectively, it still cannot deal with both challenges at the same time. Theoretical analysis and experimental results upon real and synthetic data sets illustrate the high effectiveness and efficiency of our proposed solutions.

关键词： entity matching mapReduce load balancing,pair deduplication

Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi yang D.P.nagahawaththa n.m.Liyanage Kyung-mo Song yun-Sang Choi Seung-Hong Lee you-jin Jeon min-Cheol Kang Department of marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

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