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An optimized ion trap geometry to measure quadrupole shifts of ^(171)Yb~＋ clocks

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Chinese Physics B 2016年第11期25卷 230-237页

作者： N batra B k Sahoo S De Academy of Scientific and Innovative Research CSIR-NPL Campus New Delhi India CSIR-National Physical Laboratory Dr. K. S. Krishnan Marg New Delhi 110012 India Theoretical Physics Division Physical Research Laboratory Navrangpura Ahmedabad 380009 India

We propose a new ion-trap geometry to carry out accurate measurements of the quadrupole shifts in the （171）Yb *** trap will minimize the quadrupole shift due to the harmonic component of the confining potential by an order of *** will be useful to reduce the uncertainties in the clock frequency measurements of the 6s 2S（1/2）→4f（13）6s2 2F（7/2）and 6s 2S（1/2）→5d2D（3/2） transitions,from which we can deduce the precise values of the quadrupole moments（0s） of the 4f（13）6s2 2F（7/2） and 5d2D（3/2） ***,it may be able to affirm the validity of the measured 0 value of the4f（13）6s22F（7/2） state,for which three independent theoretical studies defer almost by one order of magnitude from the *** also calculate 0s using the relativistic coupled-cluster（RCC） *** use these 0 values to estimate the quadrupole shift that can be measured in our proposed ion trap experiment.

关键词： validity minimize carry clock relativistic precise deduce magnitude expectation spatially

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

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Signal Transduction and Targeted Therapy 2021年第2期6卷 324-338页

作者： Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder k.batra Mohammad Haris Muzafar A.Macha Functional and Molecular Imaging Laboratory Cancer Research DepartmentSidra MedicineDohaQatar Department of Zoology School of Life SciencesCentral University of KashmirGanderbalJammu&KashmirIndia Department of Nephrology All India Institute of Medical SciencesNew DelhiIndia Department of Biochemistry All India Institute of Medical SciencesNew DelhiIndia Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaJammu&KashmirIndia Laboratory of Cancer Immunogenomics Cancer Research DepartmentSidra MedicineDohaQatar Department of Surgery University of MiamiMiamiFLUSA Academic Health System Hamad Medical CorporationDohaQatar Department of Biochemisty and Molecular Biology University of Nebraska Medical CenterOmahaNEUSA Eppley Institute for Research in Cancer and Alied Diseases University of Nebraska Medical CenterOmahaNEUSA Buffet Cancer Center University of Nebraska Medical CenterOmahaNEUSA Laboratory Animal Research Center Qatar UniversityDohaQatar

Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage *** clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of *** signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most *** is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in ***,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)*** review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor ***,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC.

关键词： targeted squamous thereby

Tumor-and osteoclast-derived NRP2 in prostate cancer bone metastases

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Bone Research 2021年第2期9卷 233-247页

作者： Navatha Shree Polavaram Samikshan Dutta Ridwan Islam Arup k.Bag Sohini Roy David Poitz Jeffrey karnes Lorenz C.Hofbauer Manish kohli Brian A.Costello Raffael Jimenez Surinder k.batra Benjamin A.Teply Michael H.Muders kaustubh Datta Department of Microbiology and Pathology University of Nebraska Medical CenterOmahaNEUSA Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNEUSA Institute for Clinical Chemistry University Hospital DresdenDresdenGermany Department of Urology Mayo ClinicRochesterMNUSA Center for Healthy Aging and Bone Lab Dresden Department of Medicine IIITechnische Universität DresdenDresdenGermany School of Medicine Division of OncologyHuntsman Cancer InstituteSalt Lake CityUTUSA Division of Anatomic Pathology Department of Pathology and Laboratory MedicineMayo ClinicRochesterMNUSA Internal Medicine Division of Oncology&HematologyUniversity of Nebraska Medical CenterOmahaNEUSA Rudolf-Becker Laboratory for Prostate Cancer Research Institute of PathologyUniversity of Bonn Medical CenterBonnGermany

Understanding the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone *** observed a significant upregulation of NRP2 in prostate cancer cells metastasized to ***,we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis,implicating NRP2 as a promising therapeutic ***,osteoclasts present in the tumor microenvironment express NRP2,we have investigated the potential effect of targeting NRP2 in *** results revealed NRP2 negatively regulates osteoclast differentiation and function in the presence of prostate cancer cells that promotes mixed bone *** study further delineated the molecular mechanisms by which NRP2 regulates osteoclast ***,depletion of NRP2 in osteoclasts in vivo showed a decrease in the overall prostate tumor burden in the *** results therefore indicate that targeting NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis.

关键词： metastasis chemotherapy treatment

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松香共聚酯应用于表面涂料

林业勘察设计 1986年第1期 57-62页

作者： k.batra 张晓佳福建省上杭县林产化工厂

聚双酚邻苯二甲酸酯或聚双酚马来酸酯和松香同时与丙三醇的酯化反应,所得产品称为共聚酯。本文报导了松香共聚酯及其清漆的制备方法,测定了其漆膜性能,即干燥时间、刮痕硬度、膜的柔韧性、耐水、耐碱、耐酸性和抗溶剂性。同时对松香共... 详细信息

聚双酚邻苯二甲酸酯或聚双酚马来酸酯和松香同时与丙三醇的酯化反应,所得产品称为共聚酯。本文报导了松香共聚酯及其清漆的制备方法,测定了其漆膜性能,即干燥时间、刮痕硬度、膜的柔韧性、耐水、耐碱、耐酸性和抗溶剂性。同时对松香共聚酯清漆和酯胶清漆的性能作了详细的比较,结果发现松香共聚酯清漆的漆膜性能比酯胶清漆的漆膜性能更好。

关键词：松香马来酸丙三醇 PBP 乳化剂多元醇清漆表面涂料共聚酯

Evaluation of corrosion resistance, mechanical integrity loss and biocompatibility of PCL/HA/TiO_(2) hybrid coated biodegradable ZM21 Mg alloy

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Journal of Magnesium and Alloys 2022年第11期10卷 3179-3204页

作者： Navdeep Singh Uma batra kamal kumar Anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh 160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh 160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS 67260United States

A novel PCL/HA/TiO_(2)hybrid coating on ZM21 Mg alloy substrate has been investigated for corrosion resistance, biocompatibility and mechanical integrity loss in terms of bending, compressive and tensile strength in physiological media. The prepared hybrid coating was dip coated over ZM21 from HA/TiO_(2)and PCL solutions followed by creating a microporous PCL layer by utilizing Non-solvent Induced Phase Separation(NIPS) technique. The electrochemical measurement and in-vitro degradation study in SBF after 28 days showed that the PCL/HA/TiO_(2) hybrid coating reduced H2 evolution rate, weight loss, and corrosion rate by 64, 116 and 118 times respectively, as compared to uncoated ZM21 samples. The surface studies carried out using SEM-EDX, FTIR and XRD revealed formation of highly stable 3d flower-like HA crystals with Ca/P ratio of 1.60 in the PCL micropores. This dense apatite growth effectively protected the PCL/HA/TiO_(2)hybrid coated samples to maintain the good mechanical integrity even after 28 days of immersion as compared to HA/TiO_(2)composite coated, As-polished(A/P) and As-machined(A/M) samples. The failure analysis of samples under mechanical loading were performed using *** in-vitro cellular viability of L929 fibroblast cells on PCL/HA/TiO_(2)hybrid coating was found 50.47% higher with respect to control group,whereas bacterial viability was supressed by 57.15 and 62.35% against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacterial models. The comprehensive assessment indicates PCL/HA/TiO_(2)hybrid coating as a suitable candidate to delay early degradation and mechanical integrity loss of Mg-based alloys for devising biodegradable orthopaedic implant.

关键词： Magnesium alloy Surface modification Hybrid coating Mechanical integrity loss Degradation rate Biocompatibility

Investigating TiO_(2)-HA-PCL hybrid coating as an efficient corrosion resistant barrier of ZM21 Mg alloy

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Journal of Magnesium and Alloys 2021年第2期9卷 627-646页

Surface modification for improving corrosion resistance of Mg alloys is highly demanded for degradable orthopedic and cardiovascular *** research reports the design and development of TiO_(2)–HA composite and novel TiO_(2)–HA–PCL hybrid coating belonging to the unique class of inorganic organic hybrid with striking features that are explored for the first time in the corrosion resistance of Mg ***–gel dip coating combined with non-solvent induced phase separation is used to create the hybrid ***_(2)–HA–PCL hybrid coating introduces strong hydrogen bonding between TiO_(2)–HA inorganic matrix and PCL organic layer in addition to the Vander wall electrostatic interaction of the later with the Mg substrate which in turn enhance adhesion strength to about 1.5 times of TiO_(2)–HA *** corrosion potentials for TiO_(2)–HA–PCL and TiO_(2)–HA were found to be-0.407 V and-1.017 V(vs Ag/Ag Cl),*** current densities of TiO_(2)–HA–PCL and TiO_(2)–HA were found to be 7.31×10^(-8)A/cm^(2)and 4.03×10^(-4)A/cm^(2)*** corrosion resistance of coatings was confirmed by immersion testing by weight loss,pH changes and H_(2)evolution measurements at interval of 7 days till 28 *** present TiO_(2)–HA–PCL coating in comparison to TiO_(2)–HA coating demonstrate nearly 6%less weight *** outcome of the present work was compared with the similar coatings in recent *** work done ingresses enhancing the corrosion resistance of Mg alloys,which fulfill the dreams of future degradable orthopedic and cardiovascular devices.

关键词： Corrosion resistance TiO_(2)-HA-PCL Contact angle Adhesion strength

Structure of Comparative Advantage of China and India： Global and Regional Dynamics

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China & World Economy 2007年第6期15卷 69-86页

作者： Amita batra Senior Fellow Indian Council for Research on International Economic Relations New Delhi India.

This paper investigates the extent of competition between China and lndia in the world and ASEAN markets. The analysis is undertaken using the concept of revealed comparative advantage, relative market shares, long-term trend analysis and statistical tests of convergence. In the context of the ASEAN market the evaluation of competition between India and China has been undertaken with special reference to the prior implementation of the ASEAN-China Free Trade Area relative to the ASEAN-India Free Trade Area. The results suggest that threat perceptions at the product level might currently prevail for both economies from each other across all sectors in both markets even though the intensity of the competitive threat varies across products. However, long-term trend analysis shows that the patterns of comparative advantage of India and China are evolving along divergent paths and, therefore, competition between the two economies might not be a major issue.

关键词： Asian economic integration competitive threat market share revealed comparative advantage

Novel PA encapsulated PCL hybrid coating for corrosion inhibition of biodegradable Mg alloys:A triple triggered self-healing response for synergistic multiple protection

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Journal of Magnesium and Alloys 2023年第4期11卷 1440-1460页

作者： Navdeep Singh Grewal Uma batra kamal kumar Anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh 160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh 160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS 67260USA

Surface coatings have been extensively used to control the degradation rate of Mg alloys for bioimplant ***,these coatings only act as passive *** corrosive media,structural damage impairs their barrier properties,resulting in rapid degradation of Mg *** present study incorporates phytic acid(PA)as a healing agent in polycaprolactone(PCL)microcapsules with a unique honeycomb core matrix to obtain a self-healing PA-PCLcaps *** contact between simulated body fluid(SBF)and PA-PCLcaps coated ZM21 exhibited Cassie-Baxter interfacial states,resulting in significant hydrophobicity with a contact angle(CA)of *** corrosion potential(Ecorr)and current density(Icorr)were found to be-0.28 V and 1.1×10^(-9)A/cm^(2),respectively,for PA-PCLcaps coating,resulting in biosafe corrosion rate of 2.5×10^(-4)mm/*** mechanical scratching,rapid HA mineralization at scratched regions recovered the hydrogen evolution rate(HER,0.36 mL/cm^(2)/day)and pH change(pH 7.10)of scratched PA-PCLcaps coated ZM21 samples to corresponding unscratched samples within one day of *** coating’s self-healing ability could be attributed to PA released from punctured microcapsules,which facilitates HA *** pH-triggered(pH 10)and Mg(II)-triggered(5 mM)conditions enhanced PA release from PA-PCLcaps coating by 2.5 and 3.1 times,*** a result,dense HA mineralization occurred,which protects the coating from structural defects and ensures its durability in stimulating *** findings of present study provide new insight for design of multiple stimuli-feedback based self-healing coatings on biodegradable Mg alloys.

关键词： Self-healing coating Corrosion resistance Magnesium alloy Phytic acid Polycaprolactone microcapsules

In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts

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Journal of Integrative Medicine 2017年第4期15卷 320-325页

作者： Pragya Sharma Sonali batra Ashwani kumar Anupam Sharma University Institute of Pharmaceutical Sciences Panjab University

OBJECTIVE： Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively. METHODS： Extracts of M. panicu/ata made with petroleum ether （60-80 ℃）, chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions （F1-F5）. Fraction F5 （100 mg/kg）, which showed notable anxiolytic activity, was further chromatographed to get four subfractions （F5.1-F5.4）. Simultaneously, the ethano extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction （EASF） and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M paniculata leaf extract by thin-layer chromatography was also carried out. RESULTS： Fraction F5.3 （25 mg/kg） and EASF （20 mg/kg） showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity. CONCLUSION： The results validate the traditional use of M. paniculata leaves in the treatment of menta disorders.

关键词： Murraya paniculata anxiety depressant coumarins mahanimbine plants, medicinal