Tumor-and osteoclast-derived NRP2 in prostate cancer bone metastases

作     者：Navatha Shree Polavaram Samikshan Dutta Ridwan Islam Arup K.Bag Sohini Roy David Poitz Jeffrey Karnes Lorenz C.Hofbauer Manish Kohli Brian A.Costello Raffael Jimenez Surinder K.Batra Benjamin A.Teply Michael H.Muders Kaustubh Datta Navatha Shree Polavaram;Samikshan Dutta;Ridwan Islam;Arup K.Bag;Sohini Roy;David Poitz;Jeffrey Karnes;Lorenz C.Hofbauer;Manish Kohli;Brian A.Costello;Raffael Jimenez;Surinder K.Batra;Benjamin A.Teply;Michael H.Muders;Kaustubh Datta

作者机构：Department of Microbiology and PathologyUniversity of Nebraska Medical CenterOmahaNEUSA Department of Biochemistry and Molecular BiologyUniversity of Nebraska Medical CenterOmahaNEUSA Institute for Clinical ChemistryUniversity Hospital DresdenDresdenGermany Department of UrologyMayo ClinicRochesterMNUSA Center for Healthy Aging and Bone Lab DresdenDepartment of Medicine IIITechnische Universität DresdenDresdenGermany School of MedicineDivision of OncologyHuntsman Cancer InstituteSalt Lake CityUTUSA Division of Anatomic PathologyDepartment of Pathology and Laboratory MedicineMayo ClinicRochesterMNUSA Internal MedicineDivision of Oncology&HematologyUniversity of Nebraska Medical CenterOmahaNEUSA Rudolf-Becker Laboratory for Prostate Cancer ResearchInstitute of PathologyUniversity of Bonn Medical CenterBonnGermany 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2021年第9卷第2期

页      面：233-247页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by R01 CA 239343-01A1 (K.D.), RO1 CA 182435 (K.D.) Fred and Pamela Buffet cancer center pilot grant (K.D.,2017 & 2018)R21CA241234-01 (S.D.) NE-DHHS-LB506 2020-21 (S.D.) DFG grant (L.C.H. and M.H.M.,project number: 27367690) The Rudolf-Becker-Foundation for translational prostate cancer research (M.H.M.) DFG Schwerpunktprogramm-2084 (L.C.H., μBONE) UO1 CA185148 (S.K.B.) DOD PC170891 (S.K.B.) 

主　　题：metastasis chemotherapy treatment 

摘      要：Understanding the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone *** observed a significant upregulation of NRP2 in prostate cancer cells metastasized to ***,we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis,implicating NRP2 as a promising therapeutic ***,osteoclasts present in the tumor microenvironment express NRP2,we have investigated the potential effect of targeting NRP2 in *** results revealed NRP2 negatively regulates osteoclast differentiation and function in the presence of prostate cancer cells that promotes mixed bone *** study further delineated the molecular mechanisms by which NRP2 regulates osteoclast ***,depletion of NRP2 in osteoclasts in vivo showed a decrease in the overall prostate tumor burden in the *** results therefore indicate that targeting NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis.