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世界儿科杂志:英文版 2016年第4期12卷 408-414页

作者： Nishant Jaiswal Meenu Singh Ritika Kondel Navjot Kaur Kiran K.Thumburu Ajay Kumar Harpreet Kaur Neelima Chadha Neeraj Gupta Amit Agarwal Samir malhotra Nusrat Shafiq ICMR Advanced Centre for Evidence Based Child Health Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Pharmacology Postgraduate Institute of Medical Education and ResearchChandigarh160012India Department of Pediatrics Postgraduate Institute of Medical Education and ResearchChandigarhIndia Dr.Tulsi Das Library Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Library University Business SchoolPunjab UniversityChandigarhIndia Department of Pediatrics AIIMSJodhpurRajasthanIndia

Background:Neonatal sepsis is a leading cause of neonatal deaths in developing *** current recommended in-hospital treatment is parenteral ampicillin(or penicillin)and gentamicin in young infants for 10-14 days;however,very few could access and *** current review is to evaluate the feasibility of gentamicin in community based ***:Both observational and randomized controlled trials were ***,Embase,Cochrane Central Register of Controlled Trials and Central Trial Register of India were searched until September *** assessed the risk of bias by Cochrane Collaboration’s"risk of bias"***:Two observational studies indicated feasibility ensuring coverage of population,decrease in case fatality rate in the group treated by community health *** an RCT,no significant difference was observed in the treatment failure rates[odds ratio(OR)=0.88],and the mortality in the first and second week(OR=1.53;OR=2.24)between gentamicin and ceftriaxone *** the gentamicin group,the combination of penicillin and gentamicin showed a lower rate of treatment failure(OR=0.44)and mortality at second week of life(OR=0.17)as compared to the combination of gentamicin and oral ***:Gentamicin for the treatment of neonatal sepsis is both feasible and effective in community-based settings and can be used as an alternative to the hospitalbased care in resource compromised *** there was less evidence in the management of neonatal sepsis in hospitals as was seen in this review in which we included only one RCT and three observational studies.

关键词： gentamicin neonatal sepsis neonates

Leg Length Discrepancy in Cementless Total Hip Arthroplasty

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Surgical Science 2011年第4期2卷 183-187页

作者： Christopher N Peck Karan malhotra Winston Y Kim 不详

The use of cementless total hip arthroplasty (THA) is on the increase. In order to achieve rotational and axial stability larger implants may be required than originally templated for. This could potentially result in a lar-ger leg length inequality. Our objective was to determine whether there is greater inequality in leg length post-operatively in cementless THA as compared to cemented implants. 136 consecutive patients undergoing elective THA between June 2007 and May 2008 were included. Post-operative digital radiographs were ex-amined to determine leg length. Twenty seven patients (20%) underwent a cemented procedure and 109 (80%) a cementless procedure. In the cemented group the mean leg length discrepancy was 7.3 mm (range 19 mm short to 21 mm long). In the cementless group the mean measured leg length discrepancy was 6.3 mm (range 18 mm short to 23 mm long). There was no significant difference between the two groups (P = 0.443). This study shows that with accurate pre-operative templating, both cemented and cementless proce-dures produce comparable and acceptable leg length discrepancies.

关键词： Hip Arthroplasty Cementless Leg Length

Is nitric oxide level affected in postmenopausal women with hypothyroidism?

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World Journal of Obstetrics and Gynecology 2017年第3期6卷 16-20页

作者： Kiran Dahiya Deepika Dalal Veena Singh Ghalaut Department of Biochemistry Pt.BD Sharma PGIMSRohtakHaryana 124001India Vani malhotra（Department of Obstetrics and Gynecology Pt.BD Sharma PGIMSRohtakHaryana 124001India）Sameer Aggarwal Department of Medicine Pt.BD Sharma PGIMSRohtakHaryana 124001India）Ashish Kumar Mali Department of Psychiatry Pt.BD Sharma PGIMSRohtakHaryana 124001IndiaPriya Dahiya Department of Obstetrics and Gynecology Rajshree Medical Research InstituteBareillyUP 243501India

AIMTo analyze serum levels of nitric oxide （NO）, an indicator of cardiovascular health, in post-menopausal females with and without hypothyroidism. METHODSNO was analyzed colorimetrically in 30 newly diag-nosed hypothyroid postmenopausal females and 30 postmenopausal females with normal thyroid profle. Results were compared and subjected to appropriate statistical analysis. RESULTSThe levels of serum NO were found to be significantlydecreased in postmenopausal females with hypothyroidismas compared to the levels in those with normal thyroidprofile （P value 〈 0.05）. A negative correlation of NOwas observed with thyroid stimulating hormone whereasa positive correlation of NO was observed with free T3 （FT3）, free T4 （FT4）, T3 and T4 though it was statistically signifcant only for FT4 among postmenopausal females with *** hypothyroid females may be at a risk of compromised cardiovascular health as indicated by low NO levels. Regular monitoring and risk assessment is essential for timely intervention.

关键词： Nitric oxide Menopause Thyroid profile Hypothyroidism Cardiovascular health

Autosegmentation of cardiac substructures in respiratory-gated,non-contrasted computed tomography images

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World Journal of Clinical Oncology 2021年第2期12卷 95-102页

作者： Mark Farrugia Han Yu Anurag K Singh Harish malhotra Department of Radiation Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14203United States Department of Biostatistics and Bioinformatics Roswell Park Comprehensive Cancer CenterBuffaloNY 14203United States

BACKGROUND Radiation dose to specific cardiac substructures can have a significant on treatment related morbidity and mortality,yet definition of these structures is labor intensive and not *** software may potentially address these issues,however it is unclear whether this approach can be broadly applied across different treatment planning *** investigated the feasibility of autosegmentation of the cardiac substructures in four-dimensional(4D)computed tomography(CT),respiratory-gated,non-contrasted *** To determine whether autosegmentation can be successfully employed on 4DCT respiratory-gated,non-contrasted *** We included patients who underwent stereotactic body radiation therapy for inoperable,early-stage non-small cell lung cancer from 2007 to *** patients were simulated via 4DCT imaging with respiratory gating without intravenous *** structure quality was evaluated by degree of required manual edits and volume discrepancy between the autocontoured structures and its edited sister *** Initial 17-structure cardiac atlas was generated with 20 patients followed by three successive iterations of 10 patients using MIM *** great vessels and heart chambers were reliably autosegmented with most edits considered *** contrast,coronary arteries either failed to be autosegmented or the generated structures required major alterations necessitating deletion and manual ***,the generated mitral and tricuspid valves were poor whereas the aortic and pulmonary valves required at least minor and moderate changes *** the majority of subsites,the additional samples did not appear to substantially impact the quality of generated *** analysis between autosegmented and its manually edited sister structure yielded comparable findings to the physician-based assessment of structure *** The use of MIM software with 30-sample subj

关键词： Autosegmentation Autocontouring Lung cancer Radiation therapy Heart substructures Stereotactic body radiation therapy

Identifying high-z AGNs with X-ray colors

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Identifying high-z AGNs with X-ray colors

Management of non-alcoholic fatty liver disease in 2015

中国天文学会星系分会2004年学术年会

作者： Sangeeta malhotra James Rhoads Colin Norman ApJ Letter submitted ApJ Letter submitted ApJ Letter submitted

来源： cnki会议评论

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World Journal of Hepatology 2015年第30期7卷 2962-2967页

作者： Neel malhotra Melanie D Beaton Department of Medicine Division of Gastroenterology Western University London Health Sciences Centre University Hospital

There is no single pharmacologic therapy that has been approved to treat nonalcoholic fatty liver disease in the general population. The backbone of therapy currently includes intensive lifestyle modification withestablished targets for diet and weight loss. The use of unsweetened, unfiltered coffee along with limiting high fructose corn syrup have emerged as beneficial dietary recommendations. The use of empiric oral hypoglycemic agents and vitamin E, however, has not been widely accepted. Developing bariatric surgical techniques are promising, but additional studies with long-term follow up are needed before it can be widely recommended. Finally, liver transplantation is an increasingly frequent consideration once complications of endstage disease have developed. The future treatment of those with nonalcoholic fatty liver disease will likely involve a personalized approach. The importance of the gut microbiome in mediating hepatocyte inflammation and intestinal permeability is emerging and may offer avenues for novel treatment. The study of anti-fibrotic agents such as pentoxifylline and FXR agonists hold promise and new pathways, such as hepatocyte cannabinoid receptor antagonists are being studied. With the incidence of obesity and the metabolic syndrome increasing throughout the developed world, the future will continue to focus on finding novel agents and new applications of existing therapies to help prevent and to mediate the progression of nonalcoholic fatty liver disease.

关键词： Lobular inflammation Non-alcoholic fattyliver disease Non-alcoholic steatohepatitis Liver fibrosis

Single Stage Extra Cardiac Conduit Total Cavopulmonary Connection in Atrial Situs Inversus and Levocardia

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World Journal of Cardiovascular Surgery 2016年第8期6卷 99-103页

作者： Shamsher Singh Lohchab Ishani Lohchab Ashok Chahal Naveen malhotra Kuldeep Laller Department of Cardiac Surgery Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Department of Anaesthesiology Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Department of Cardiology Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India

10-year female child was presented with complex congenital heart defect—atrial situs inversus, levocardia, discordant atrioventricular connections, double outlet right ventricle, ventricular septal defect, pulmonic stenosis and straddling of atrio-ventricular valves along with bilateral superior vena cava and large patent ductus arteriosus. We describe here the strategy adopted to perform single stage fenestrated extra cardiac conduit total cavo-pulmonary connections in this patient especially concerning cardiac malposition of atrial situs inversus and levocardia.

关键词： Single Ventricle Fontan Operation Situs Inversus and Levocardia

Prevalence of hypercoagulable states in stented thrombotic iliac vein compression syndrome with comparison of re-intervention and anticoagulation regimens

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World Journal of Radiology 2021年第12期13卷 371-379页

作者： Peyton Cramer Cheryl Mensah Maria DeSancho Anuj malhotra Ronald Winokur Andrew Kesselman Department of Radiology Division of Interventional RadiologyNew York Presbyterian Hospital/Weill Cornell MedicineNew YorkNY 10065United States Department of Medicine Division of Hematology-OncologyNew York Presbyterian Hospital/Weill Cornell MedicineNew YorkNY 10065United States Department of Radiology Division of Interventional RadiologyThomas Jefferson University HospitalPhiladelphiaPennsylvania 19107United States

BACKGROUND Endovascular therapy is playing an increasing role in the treatment of iliofemoral venous *** stent patency is multifactorial,and current management is based on best clinical practices,varying by *** To evaluate how thrombophilia influences management and outcomes of patients who undergo venous stenting for thrombotic iliac vein compression *** A retrospective observational analysis was performed on 65 patients with thrombotic iliac vein compression syndrome that underwent common iliac vein(CIV)stenting between December 2013 and December 2019 at a large academic *** criteria included CIV stenting and iliac vein *** lesions and iliocaval thrombosis and/or occlusions were excluded.A total of 65 patients were selected for final *** information,procedural data points,and post-procedural management and outcomes were *** analyses included Fisher's exact and Chi-square tests to compare discrete variables and the Wilcoxon rank-sum test to compare continuous variables between thrombophilia positive and negative *** 65 patients underwent successful balloon angioplasty and CIV *** these patients,33(50.8%)underwent thrombophilia testing,with 16(48.5%)testing *** patency on ultrasound did not significantly differ between thrombophilia positive and negative patients at 1 mo(92.3%vs 81.3%,P=0.6),6 mo(83.3%vs 80%,P>0.9),or 12 mo(77.8%vs 76.9%,P=0.8).Immediately after stent placement,thrombophilia patients were more likely to be placed on dual therapy(aspirin and anticoagulation)or triple therapy(aspirin,clopidogrel,and anticoagulation)(50%vs 41.2%,P>0.9),and remain on dual therapy at 6 mo(25%vs 12.5%,P=0.5)and 12 mo(25%vs 6.7%,P=0.6).There was no significant difference in re-intervention rates(25%vs 35.3%,P=0.7)or number of reinterventions(average 2.3 vs 1.3 per patient,P=0.4)between thrombophilia positive and negative ***

关键词： Thrombophilia Iliac vein compression syndrome Iliac vein stent May Thurner Anticoagulation Endovascular

Computed tomography angiographic study of surgical anatomy of thyroid arteries:Clinical implications in neck dissection

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World Journal of Radiology 2023年第6期15卷 182-190页

作者： Yashu Bhardwaj Brijendra Singh Pooja Bhadoria Rashmi malhotra Swarnava Tarafdar Kanchan Bisht Department of Anatomy All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia Department of Radiodiagnosis All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia

BACKGROUND The course and variations of thyroid arteries must be understood by surgeons to prevent bleeding during operative procedures of the thyroid *** is limited scientific literature regarding the radiological anatomy of thyroid arteries in this geographical area,the Garhwal region of Sub-Himalayan belt,which is considered to be the endemic belt of *** tomography angiography provides a three-dimensional orientation of the vascular and surgical anatomy of the entire cervical *** To estimate the proportion of variation in origin of thyroid arteries using Computed Tomography *** Using Computed Tomography Angiography,the presence and origin of the superior thyroid artery,inferior thyroid artery,and thyroid ima artery were observed and *** Out of total 210 subjects,superior thyroid artery was seen to be emerging from external carotid artery in 77.1%*** artery was found to be originating at the level of bifurcation of common carotid artery in 14.3%cases,whereas in 8.6%cases,it emerged as a direct branch of the common carotid ***,the inferior thyroid artery was observed to be emerging from thyrocervical trunk,subclavian artery and vertebral artery in 95.7%cases,3.3%and 1%cases,*** ima artery was also reported in a subject,arising from the brachiocephalic *** To avoid vascular injuries,excessive and uncontrollable bleeding,intra-operative difficulties,and post-operative issues,it is imperative for surgeons to be aware of the course and variations of thyroid arteries。

关键词： Thyroid arteries Computed tomography angiography Origin Variation