Is nitric oxide level affected in postmenopausal women with hypothyroidism?

作     者：Kiran Dahiya Deepika Dalal Veena Singh Ghalaut Kiran Dahiya;Deepika Dalal;Vani Malhotra;Sameer Aggarwal;Ashish Kumar Malik;Veena Singh Ghalaut;Priya Dahiya

作者机构：Department of BiochemistryPt.BD Sharma PGIMSRohtakHaryana 124001India Vani Malhotra（Department of Obstetrics and GynecologyPt.BD Sharma PGIMSRohtakHaryana 124001India）Sameer Aggarwal Department of MedicinePt.BD Sharma PGIMSRohtakHaryana 124001India）Ashish Kumar Mali Department of PsychiatryPt.BD Sharma PGIMSRohtakHaryana 124001IndiaPriya Dahiya Department of Obstetrics and GynecologyRajshree Medical Research InstituteBareillyUP 243501India 

出 版 物：《World Journal of Obstetrics and Gynecology》 (世界妇产科杂志)

年 卷 期：2017年第6卷第3期

页      面：16-20页

学科分类：1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：Nitric oxide Menopause Thyroid profile Hypothyroidism Cardiovascular health 

摘      要：AIMTo analyze serum levels of nitric oxide （NO）, an indicator of cardiovascular health, in post-menopausal females with and without hypothyroidism. METHODSNO was analyzed colorimetrically in 30 newly diag-nosed hypothyroid postmenopausal females and 30 postmenopausal females with normal thyroid profle. Results were compared and subjected to appropriate statistical analysis. RESULTSThe levels of serum NO were found to be significantlydecreased in postmenopausal females with hypothyroidismas compared to the levels in those with normal thyroidprofile （P value 〈 0.05）. A negative correlation of NOwas observed with thyroid stimulating hormone whereasa positive correlation of NO was observed with free T3 （FT3）, free T4 （FT4）, T3 and T4 though it was statistically signifcant only for FT4 among postmenopausal females with *** hypothyroid females may be at a risk of compromised cardiovascular health as indicated by low NO levels. Regular monitoring and risk assessment is essential for timely intervention.