Feasibility and efficacy of gentamicin for treating neonatal sepsis in community-based settings:a systematic review

作     者：Nishant Jaiswal Meenu Singh Ritika Kondel Navjot Kaur Kiran K.Thumburu Ajay Kumar Harpreet Kaur Neelima Chadha Neeraj Gupta Amit Agarwal Samir Malhotra Nusrat Shafiq 

作者机构：ICMR Advanced Centre for Evidence Based Child HealthPostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of PharmacologyPostgraduate Institute of Medical Education and ResearchChandigarh160012India Department of PediatricsPostgraduate Institute of Medical Education and ResearchChandigarhIndia Dr.Tulsi Das LibraryPostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of LibraryUniversity Business SchoolPunjab UniversityChandigarhIndia Department of PediatricsAIIMSJodhpurRajasthanIndia 

出 版 物：《世界儿科杂志:英文版》 (World Journal of Pediatrics)

年 卷 期：2016年第12卷第4期

页      面：408-414页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：funded by ICMR New Delhi(grant number 5/7/592/11-RHN) 

主　　题：gentamicin neonatal sepsis neonates 

摘      要：Background:Neonatal sepsis is a leading cause of neonatal deaths in developing *** current recommended in-hospital treatment is parenteral ampicillin(or penicillin)and gentamicin in young infants for 10-14 days;however,very few could access and *** current review is to evaluate the feasibility of gentamicin in community based ***:Both observational and randomized controlled trials were ***,Embase,Cochrane Central Register of Controlled Trials and Central Trial Register of India were searched until September *** assessed the risk of bias by Cochrane Collaboration’srisk of bias***:Two observational studies indicated feasibility ensuring coverage of population,decrease in case fatality rate in the group treated by community health *** an RCT,no significant difference was observed in the treatment failure rates[odds ratio(OR)=0.88],and the mortality in the first and second week(OR=1.53;OR=2.24)between gentamicin and ceftriaxone *** the gentamicin group,the combination of penicillin and gentamicin showed a lower rate of treatment failure(OR=0.44)and mortality at second week of life(OR=0.17)as compared to the combination of gentamicin and oral ***:Gentamicin for the treatment of neonatal sepsis is both feasible and effective in community-based settings and can be used as an alternative to the hospitalbased care in resource compromised *** there was less evidence in the management of neonatal sepsis in hospitals as was seen in this review in which we included only one RCT and three observational studies.