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Endoscopic ultrasound fine needle aspiration vs fine needle biopsy for pancreatic masses,subepithelial lesions,and lymph nodes

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World journal of Gastroenterology 2021年第26期27卷 4194-4207页

作者： Irving levine Arvind j Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health SystemNew Hyde ParkNY 11040United States

Endoscopic ultrasound tissue acquisition,in the form of both fine needle aspiration(EUS-FNA)and fine needle biopsy(EUS-FNB),is utilized for pancreatic mass lesions,subepithelial lesions,and lymph node *** procedures are safe and yield high diagnostic *** its high diagnostic yield,EUS-FNA has potential limitations associated with cytological aspirations,including inability to determine histologic architecture,and a small quantitative sample for further immunohistochemical ***-FNB,with its larger core biopsy needle,was designed to overcome these potential ***,it remains unclear which technique should be used and for which *** trials are plagued by heterogeneity at every stage of comparison;including variable needles used,and different definitions of endpoints,which therefore limit ***,we present a review of prospective trials,systematic reviews,and meta-analyses on studies examining EUS-FNA vs *** comparative trials of EUS-FNA vs EUS-FNB primarily focus on pancreatic mass lesions,and yield conflicting results in terms of demonstrating the superiority of one ***,consistent among trials is the potential for diagnosis with fewer passes,and a larger quantity of sample achieved for next generation *** regard to subepithelial lesions and lymph node biopsy,fewer prospective trials exist,and larger prospective studies are *** on the available literature,we would recommend EUS-FNB for peri-hepatic lymph nodes.

关键词： Endoscopic ultrasound fine needle aspiration Endoscopic ultrasound fine needle biopsy Pancreatic lesions Subepithelial lesions Lymph node biopsy

Modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review

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Asian journal of Andrology 2020年第1期22卷 51-59页

作者： Matthew j Ziegelmann M Ryan Farrell Laurence A levine Division of Urology Rush University Medical CenterChicagoIL 60612USA

Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual *** dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment *** a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly *** some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate ***,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without *** patients with severe penile shortening,penile length restoration techniques may also be ***,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's ***,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes.

关键词： collagenase grafting penile length penile prosthesis Peyronie's

Winter Temperature and UV are Tightly Linked to Genetic Changes in the p53 Tumour Suppressor Pathway in Eastern Asia

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Winter Temperature and UV are Tightly Linked to Genetic Chan...

Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events

“基因、进化与生理功能多样性”海内外学术研讨会暨中国生理学会第七届比较生理学学术会议

作者： arnold levine 宿兵 Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology and Kunming Primate Research CentreChinese Academy of SciencesKunming

The tumour suppressor p53 is a master sensor of *** human specific polymorphisms, p53 Codon 72 and MDM2 SNP309,influence the activities of *** is a tight association between cold winter temperature and p53 Arg72,and low UV intensity and MDM2 SNP309 G/G,in a cohort of 4,029 individuals across Eastern Asia that suggests causative selec- ***,the two polymorphisms are not ***-based selection analysis further suggests that this is a striking example of two functional polymorphisms being strongly selected for in human populations in response to environmental stresses.

关键词： Winter temperature UV p53

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Stroke & Vascular Neurology 2024年第5期9卷 519-529页

作者： jason j Sico Xin Hu Laura j Myers Deborah levine Dawn M Bravata Greg W Arling Internal Medicine and Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Yale School of Public Health New HavenConnecticutUSA VA Health Services Research and Development(HSR&D)Center for Healthcare Informatics and Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) IndianapolisIndianaUSA Richard L.Roudebush VA Medical Center IndianapolisIndianaUSA Departments of Medicine and Neurology University of Michigan School of MedicineAnn ArborMichiganUSA Health Services Research and Development(HSR&D)Center for Healthcare Informatics and Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Department of Veterans Affairs(VA) Health Services Research and Development(HSR&D)Precision Monitoring to Transform Care(PRISM)Quality Enhancement Research Initiative(QUERI)IndianapolisIndianaUSA Department of Nursing Purdue UniversityWest LafayetteIndianaUSA

Introduction Whether obtaining the more intensive goal systolic blood pressure(SBP)of140mm Hg).Separate multivariable Cox proportional hazard regressions were used to examine the relationship between average SBP group... 详细信息

Introduction Whether obtaining the more intensive goal systolic blood pressure(SBP)ofjuly *** were excluded from the study if they had missing or extreme BP values,receiving dialysis or palliative care,left against medical advice had a cancer diagnosis,were cared for in a VAMC enrolled in a stroke/TIA quality improvement initiative,died or had a cerebrovascular or cardiovascular event within 90 days after their index stroke/*** analytical sample included 12337 *** SBP during 90 days after discharge was assessed in categories(≤105mm Hg,106–115mm Hg,116–130mm Hg,131–140mm Hg and>140mm Hg).Separate multivariable Cox proportional hazard regressions were used to examine the relationship between average SBP groups and time to:(1)mortality and(2)any recurrent vascular event,from 90 days to up to 365 days after discharge from the index emergency department visit or inpatient *** Compared with those with SBP>140mm Hg,patients with SBP between 116 and 130mm Hg had a significantly lower risk of recurrent stroke/TIA(HR 0.77,95%CI 0.60 to 0.99)but not cardiovascular *** with SBP lower than 105mm Hg,compared with those with>140mm Hg demonstrated a statistically significant higher risk of death(HR 2.07,95%CI 1.43 to 3.00),but no statistical differences were found in other SBP *** Data support a more intensive SBP goal to prevent recurrent cerebrovascular events among stroke/TIA patients by 90 days poststroke/TIA compared with less intensive *** low SBPs were associated wit

关键词： dialysis diagnosis TIA

Transfer learning framework for multi-scale crack type classification with sparse microseismic networks

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International journal of Mining Science and Technology 2024年第2期34卷 167-178页

作者： arnold Yuxuan Xie Bing QLi Department of Civil and Environmental Engineering Western UniversityLondon N6A 3K7Canada

Rock fracture mechanisms can be inferred from moment tensors(MT)inverted from microseismic ***,MT can only be inverted for events whose waveforms are acquired across a network of *** is limiting for underground mines where the microseismic stations often lack azimuthal ***,there is a need for a method to invert fracture mechanisms using waveforms acquired by a sparse microseismic ***,we present a novel,multi-scale framework to classify whether a rock crack contracts or dilates based on a single *** framework consists of a deep learning model that is initially trained on 2400000+manually labelled field-scale seismic and microseismic waveforms acquired across 692 *** learning is then applied to fine-tune the model on 300000+MT-labelled labscale acoustic emission waveforms from 39 individual experiments instrumented with different sensor layouts,loading,and rock types in *** optimal model achieves over 86%F-score on unseen waveforms at both the lab-and *** model outperforms existing empirical methods in classification of rock fracture mechanisms monitored by a sparse microseismic *** facilitates rapid assessment of,and early warning against,various rock engineering hazard such as induced earthquakes and rock bursts.

关键词： Multi-scale Fracture processes Microseismic Acoustic emission Source mechanism Deep learning

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食物回收等级制度帮助处理剩余食物（英文）

英语画刊(高中版) 2024年第1期 12-14页

作者： Daisy Chung Ally j.levine Clare Trainor

每天,世界各个角落都会丢弃大量的剩余食物,比如吃不完的饭菜、发霉的面包和不能吃的果皮果核等。这不仅造成食物浪费,还会导致环境问题日益严重。Humans grow and waste food at a staggering(令人吃惊的)*** devote half the earth’s...

每天,世界各个角落都会丢弃大量的剩余食物,比如吃不完的饭菜、发霉的面包和不能吃的果皮果核等。这不仅造成食物浪费,还会导致环境问题日益严重。Humans grow and waste food at a staggering(令人吃惊的)*** devote half the earth’s habitable land to food production,while ultimately tossing one-third of that food.

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Emergency department management of acute agitation in the reproductive age female and pregnancy

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World journal of Emergency Medicine 2024年第2期15卷 83-90页

作者： Ariella Gartenberg Kayla levine Alexander Petrie Department of Emergency Medicine Jacobi Medical Center and Montefiore Medical CenterNY 10461USA Department of Psychiatry and Behavioral Sciences Albert Einstein College of Medicine and Montefiore Medical CenterNY 10461USA Department of Emergency Medicine Jacobi Medical Center and North Central Bronx HospitalNY 10461USA

BACKGROUND:Agitation is a common presentation within emergent departments(EDs).Agitation during pregnancy should be treated as an obstetric emergency,as the distress may jeopardize both the patient and *** safety of psychotropic medications in the reproductive age female has not been well *** review aimed to explore a summary of general agitation recommendations with an emphasis on ED management of agitation during ***:A literature review was conducted to explore the pathophysiology of acute agitation and devise a preferred treatment plan for ED management of acute agitation in the reproductive age or pregnant ***:While nonpharmacological management is preferred,ED visits for agitation often require medical *** should be selected based on the etiology of agitation and the clinical setting to avoid major adverse *** effects are common in pregnant *** mild to moderate agitation in pregnancy,diphenhydramine is an effective sedating agent with minimal adverse *** moderate to severe agitation,high-potency typical psychotropics are preferred due to their neutral effects on *** has become the most frequently utilized psychotropic for agitation during *** generation psychotropics are often utilized as second-line therapy,including *** and ketamine have demonstrated adverse fetal ***:While randomized control studies cannot be ethically conducted on pregnant patients requiring sedation,animal models and epidemiologic studies have demonstrated the effects of psychotropic medication exposure in *** the fetal risk associated with multiple doses of psychotropic medications remains unknown,weighing the risks and benefits of each agent,while utilizing the lowest effective dose remains critical in the treatment of acute agitation within the EDs.

关键词： Agitation Pregnancy Haloperidol Ketamine Benzodiazepines

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Lethal means and suicide prevention among military veterans

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Military Medical Research 2023年第1期10卷 139-140页

作者： joshua levine Leo Sher Veterans’Administration New York Harbor Healthcare System BrooklynNY 11209USA james j.Peters Veterans’Administration Medical Center BronxNY 10468USA

Dear Editor,Suicide amongst the military veteran population is a significant *** VeteranSuicidePreventionAnnualReportrevealedthat6261 died by suicide in 2019[1]. The lingering effects of the coronavirus disease 2019 (... 详细信息

关键词： Suicide Depression Public health Lethal means Military veterans

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Semiconducting Carbon Nanotube/Fullerene Blended Heterojunctions for Photovoltaic Near-Infrared Photon Harvesting

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Nano Research 2011年第11期4卷 1174-1179页

作者： Dominick j. Bindl Adam S. Brewer Michael S. arnold 1509 University Ave. Materials Science and Engineering Dept. University of Wisconsin-Madison Madison WI 53706 USA

We demonstrate that the near-infrared （NIR） absorptivity of semiconducfing single-walled carbon nanotubes （s-SWCNTs） can be harnessed in blended heterojunctions with the fullerene derivative [6,6]-phenyl-C61-butyric acid methyl ester （PCBM）. Photogenerated charge separation is efficiently driven by the ultrahigh interracial area of the blends and the favorable energy offsets between the two materials. NIR-sensitive photovoltaic and photodetector devices utilizing the stack （indium tin oxide/ca. 10 nm s-SWCNT：PCBM/100 nm Cj10 nm 2,9- dimethyl-4,7-diphenyl-],10-phenanthroline （BCP）/Ag） were fabricated with NIR power conversion efficiencies 〉1.3% and peak, zero bias external quantum efficiency of 18% at λ = 1205 nm.

关键词： Carbon nanotube bulk heterojunction photovoltaic photodetector near-infrared (NIR)