The many faces of p53:something for everyone

作     者：Arnold J.Levine Arnold J.Levine

作者机构：Institute for Advanced StudyPrincetonNJ 08540USA 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2019年第11卷第7期

页      面：524-530页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：National Institutes of Health, NIH National Cancer Institute, NCI, (5PO1CA087497-17) 

主　　题：discovery years protein 

摘      要：The p53 gene,from discovery to classification:the first 10 years Forty years ago four research laboratories in London,Paris,NewYork/Bethesda,and Princeton uncovered the existence of the p53 protein (Deleo et al.,1979;Lane and Crawford,1979;Linzer and Levine,1979;Kress et al.,1979).Each laboratory came upon this protein for a different reason and with a different experimental approach that uncovered this unanticipated ***,the four papers permitted one to con elude the following:(i) in SV40-infected and transformed cells the SV40-e ncoded on cogene protein,the large T-antigen,formed a protein complex with a cellular-encoded protein of -53000 daltons in size,(ii) This p53 protein was detected at high levels in a variety of transformed cells derived from viral,chemical,or inherited (teratocarcinomas) transformation events,(iii) Nontransformed cells expressed lower levels of the p53 protein,(iv) Animals bearing tumors produced antibodies directed against the p53 protein.