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Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19:a single-center,retrospective study

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Emergency and Critical Care Medicine 2022年第3期2卷 122-127页

作者： Neeraj kumar Sarfaraz Ahmad Mala Mahto Abhyuday kumar Prabhat k.singh Department of Trauma and Emergency All India Institute of Medical Sciences PatnaBiharIndia Department of Anaesthesiology All India Institute of Medical Sciences PatnaBiharIndia Department of Biochemistry All India Institute of Medical Sciences PatnaBiharIndia Director All India Institute of Medical Sciences PatnaBiharIndia

Background:The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 in India has been declared a public health *** patients with COVID-19 experience cardiac *** with COVID-19 admitted to the intensive care unit(ICU)with acute myocardial injury showed increased high-sensitivity troponin *** troponin levels may indicate myocardial injury and are commonly associated with ***:We conducted a retrospective observational study of 44 patients with severe COVID-19 in ICU during the second *** primary end point of our retrospective study was 28-day mortality,and the time of ICU admission was designated as day *** extracted and analyzed cardiac biomarkers,such as creatine kinase(Ck),creatine kinase-MB(Ck-MB),B-type natriuretic peptide(BNP),and high-sensitivity cardiac troponin I(hs-cTnI),and various inflammatory markers such as C-reactive protein(CRP)level,interleukin 6(IL-6),D-dimer,ferritin,lactate dehydrogenase,IL-6,and procalcitonin in patients with severe COVID-19 at ICU admission and 72 hours after ICU admission from our electronic medical record ***:The best cutoff of BNP were 326.8 and 398.5 pg/mL,Ck were 195.95 and 180.12 U/L,Ck-MB were 112.10 and 108.5 U/L,and hs-cTnI were 0.035 and 0.025 ng/mL,at ICU admission and 72 hours after ICU admission for predicting 28-day mortality among ***:In patients with severe COVID-19,Ck and hs-cTnI may be considered effective and valuable predictive cardiac biomarkers among nonsurvivors and predict poor prognosis.

关键词： Cardiac biomarkers COVID-19 Intensive care unit Mortality Prognosis Retrospective study

Low-cost high entropy alloy(HEA)for high-efficiency oxygen evolution reaction(OER)

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Nano Research 2022年第6期15卷 4799-4806页

作者： Lalita Sharma Nirmal kumar katiyar Arko Parui Rakesh Das Ritesh kumar Chandra Sekhar Tiwary Abhisek k.singh Aditi Halder krishanu Biswas School of Basic Sciences Advanced Materials Research Centre(AMRC)Indian Institute of Technology Mandi(H.P)KamandMandi 175005India Department of Materials Science and Engineering Indian Institute of Technology KanpurKanpur 208016India School of Engineering London South Bank UniversityLondonSE10 AAUK Materials Research Centre Indian Institute of ScienceBangalore 560012India Metallurgical and Materials Engineering Indian Institute of Technology KharagpurKharagpur 382355India

Oxygen evolution reaction(OER)is the key step involved both in water splitting devices and rechargeable metal-air batteries,and hence,there is an urgent need for a stable and low-cost material for efficient *** the present investigation,Co-Fe-Ga-NiZn(CFGNZ)high entropy alloy(HEA)has been utilized as a low-cost electrocatalyst for ***,after cyclic voltammetry activation,CFGNZ-nanoparticles(NPs)are covered with oxidized surface and form high entropy(oxy)hydroxides(HEOs),exhibiting a low overpotential of 370 mV to achieve a current density of 10 mA/cm^(2)with a small Tafel slope of 71 mV/*** alloy has higher electrochemical stability in comparison to state-of-the art RuO2 electrocatalyst as no degradation has been observed up to 10 h of *** electron microscopy(TEM)studies after 10 h of long-term chronoamperometry test showed no change in the crystal structure,which confirmed the high stability of *** density functional theory(DFT)based calculations show that the closeness of d(p)-band centers to the Fermi level(EF)plays a major role in determining active *** work highlights the tremendous potential of CFGNZ HEA for OER,which is the primary reaction involved in water splitting.

关键词： high entropy alloy cyclic voltammetry activation oxygen evolution reaction electrocatalyst nanocrystalline catalyst

Biocompatibility and biotoxicity of in-situ synthesized carboxylated nanodiamond-cobalt oxide nanocomposite

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Journal of Materials Science & Technology 2017年第8期33卷 879-888页

作者： L.Syam Sundar Naser A.Anjum M.C.Ferro Eduarda Pereira Manoj k.singh A.C.M.Sousa TEMA-Department of Mechanical Engineering University ofAveiroAveiroPortugal CESAM-Centrefor Environmental&Marine Studies and Department of Chemistry University of Aveiro3810-193AveiroPortugal CICECO Department of Material Engineering and CeramicsUniversity of AveiroPortugal

A nanocomposite that incorporates cobalt oxide（Co3O4） and nanodiamond（ND） can present both high magnetism（Co3O4） and high hardness（ND）. ND particles have potential applications in a variety of fields such as protein immobilization, biosensors, therapeutic molecule delivery and bio-imaging. However,limited information is available in literature on the in-situ synthesis of biocompatible magnetic materials and also on their potential biotoxicity as a result of their entry into environmental compartments and subsequent interaction with biota. In this work, a new kind of bio-compatible magnetic material –carboxylated nanodiamond（c ND） and Co3O4 was synthesized to obtain the c ND-Co3O4 *** synthesis procedure involved in-situ and chemical reduction of cobalt chloride（CoCl（26）H2O） and sodium borohydrate（NaBH4）. The synthesized cND-Co3O4 nanocomposite was characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy. The cyto-genotoxicity of the synthesized nanocomposite material was studied by using onion（Allium cepa L.） as a test model with concentrations of 5, 10 and 20 μg/ml. The study was also extended to cND and Co3O4 materials for comparison purpose. Co3O4 and cND exhibited their contrasting effects on mitosis and other cyto-genotoxic indices studied herein. This work provided fundamental data on the synthesis and the bio-toxicity of the c ND-Co3O4 nanocomposite, which, in turn, can help to expand their multidisciplinary applications.

关键词： Nanodiamond Cobalt oxide Nanodiamond Nanocomposite Bio-toxicity Allium cepa

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Deep Multiview Image Fusion for Soybean Yield Estimation in Breeding Applications

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Plant Phenomics 2021年第1期3卷 286-297页

作者： Luis GRiera Matthew ECarroll Zhisheng Zhang Johnathon MShook Sambuddha Ghosal Tianshuang Gao Arti singh Sourabh Bhattacharya Baskar Ganapathysubramanian Asheesh k.singh Soumik Sarkar Department of Mechanical Engineering Iowa State UniversityAmesIowaUSA Department of Agronomy Iowa State UniversityAmesIowaUSA Department of Computer Science Iowa State UniversityAmesIowaUSA

Reliable seed yield estimation is an indispensable step in plant breeding programs geared towards cultivar development in major row *** objective of this study is to develop a machine learning(ML)approach adept at soybean(Glycine max L.(Merr.))pod counting to enable genotype seed yield rank prediction from in-field video data collected by a ground *** meet this goal,we developed a multiview image-based yield estimation framework utilizing deep learning *** images captured from different angles were fused to estimate the yield and subsequently to rank soybean genotypes for application in breeding *** used data from controlled imaging environment in field,as well as from plant breeding test plots in field to demonstrate the efficacy of our framework via comparing performance with manual pod counting and yield *** results demonstrate the promise of ML models in making breeding decisions with significant reduction of time and human effort and opening new breeding method avenues to develop cultivars.

关键词： breeding soybean cultivar

Classification and management of community forests in Indian Eastern Himalayas:implications on ecosystem services,conservation and livelihoods

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Ecological Processes 2018年第1期7卷 297-311页

作者： Ranjay k.singh Shah M.Hussain T.Riba Anshuman singh Egul Padung Orik Rallen Y.J.Lego Ajay kumar Bhardwaj College of Horticulture and Forestry Central Agricultural UniversityPasighatArunachal Pradesh 791102India ICAR-Central Soil Salinity Research Institute KarnalHaryana 132001India Doying Gumin College East SiangPasighatArunachal PradeshIndia Pasighat India

Introduction:Evidence is mounting that traditional knowledge can play a critical role in shaping the biodiversity conservation strategies and maintaining ecosystem *** study was conducted with Adi community of Arunachal Pradesh(Ar P)state in the Eastern Indian Himalayas to understand as how local systems of forest classification governs conservation tradition and influences subsistence *** Adi villages were sampled from East Siang district of Ar P.A total of 197 men and 204 women(total of 401)Adi respondents were selected for this study.A combination of methodologies including in-depth interview,transect walks,focus group discussion,participant observation and informal interactions were combined for data ***:Local forests are classified into 10 different categories based on indicators such as topography,cultural significance,use typology,ownership rights and plant diversity *** people assign different values(economic,cultural and ecological)to different forest ***,morang followed by regpi and homegardens are perceived to be more valuable to the local needs than other forests with relative ranking of a particular forest reflecting its *** access several diverse services from these community-managed *** to men(3–35%),the role of women was assessed to be much higher(65 to 100%)in conserving forest ***-led practices,instrumental in sustainable forest management,included deliberate manipulations of micro-habitats,sustainable harvesting strategies and species *** were mostly involved in ownership and decision-making roles and in devising social norms to ensure *** celebrate a number of cultural events to sustain ***-based livelihoods are intrinsically connected to forest resource conservation and are governed by community *** of the community members gather plants,hunt wild animals and access other ecosystem se

关键词： Adi tribe Forest classification Traditional ecological knowledge Indigenous institutions Ecosystem services Conservation Livelihoods

Reprogramming plant specialized metabolism by manipulating protein kinases

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aBIOTECH 2021年第3期2卷 226-239页

作者： Ruiqing Lyu Sanjay k.singh Yongliang Liu Barunava Patra Yan Zhou Bingwu Wang Sitakanta Pattanaik Ling Yuan Department of Plant and Soil Sciences and the kentucky Tobacco Research and Development Center University of Kentucky1401 University DriveLexingtonKY 40546USA South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China Tobacco Breeding Center Yunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

Being sessile,plants have evolved sophisticated mechanisms to balance between growth and defense to survive in the harsh *** transition from growth to defense is commonly achieved by factors,such as protein kinases(Pks)and transcription factors,that initiate signal transduction and regulate specialized *** produce an array of lineage-specific specialized metabolites for chemical defense and stress *** of these molecules are also used by humans as ***,many of these defense-responsive metabolites are toxic to plant cells and inhibitory to growth and *** have,thus,evolved complex regulatory networks to balance the accumulation of the toxic *** of external stimuli is a vital part of the regulatory *** kinase-mediated signaling activates a series of defense responses by phosphorylating the target pro-teins and translating the stimulus into downstream cellular *** biosynthesis of specialized metabolites is triggered when plants perceive stimuli,a possible connection between Pks and spe-cial ized meta bolism is well ***,the roles of Pks in plant specialized metabolism have not received much attention until ***,we summarize the recent advances in understanding Pks in plant specialized *** aim to highlight how the stimulatory signals are transduced,leading to the biosynthesis of corresponding *** discuss the post-translational regulation of specialized metabolism and provide insights into the mechanisms by which plants respond to the external *** addition,we propose possible strategies to increase the production of plant spe-cial ized metabolites in biotechnological applications using Pks.

关键词： Medicinal plants Protein kinases MAP kinase Specialized metabolites Post-translational regulation Signal transd uction

Sudden sensorineural hearing loss-A contemporary review of management issues

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Journal of Otology 2020年第2期15卷 67-73页

作者： anup singh David Victor kumar Irugu Department of Otorhinolaryngology and Head and Neck Surgery Medanta-the MedicityGurugramHaryanaIndia Department of Otorhinolaryngology and Head and Neck Surgery All India Institute of Medical SciencesNew DelhiIndia

Sudden sensorineural hearing loss(SSNHL)is an enigmatic entity,with obscure pathophysiology and debatable efficacy of the treatment agents *** underlying cause is identified in only 10-15%of *** management of the remaining patients,classified as‘idiopathic’,is empirical,and is conventionally with systemic steroids,vasodilator therapy,rheological agents,and antioxidants,to list a few amongst the host of the agents employed for the *** availability of conflicting outcomes and lack of conclusive evidence has resulted in the propagation of consensus-based treatment *** the present review,we discuss the various controversial issues and newer developments in the management of idiopathic *** current review aims to present a narrative outlook of the updated evidence base available from PUBMED,augmented with relevant designated publications.

关键词： Hearing loss Sudden Sensorineural Instillation Drug Dexamethasone Prognosis

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A field study of a roof bolter canopy air curtain(2nd generation)for respirable coal mine dust control

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International Journal of Mining Science and Technology 2019年第5期29卷 711-720页

作者： W.R.Reed S.klima M.Shahan G.J.H.Ross k.singh R.Cross T.Grounds CDC NIOSH Pittsburgh Mining Research DivisionPittsburghPA 15236USA Fletcher&Co. HuntingtonWV 25705USA Prairie State Generating Company LLC Lively GroveIL 62257USA

A 2nd generation roof bolter canopy air curtain(CAC)design was tested by National Institute for Occupational Safety and Health(NIOSH)at a Midwestern underground coal *** the study,the roof bolter never operated downwind of the continuous *** a combination of personal Data Rams(pDR)and gravimetric samplers,the dust control efficiency of the roof bolter CAC was *** evaluation was determined using three methods:(1)comparing roof bolter operator concentrations underneath the CAC to roof bolter concentrations outside the CAC,(2)comparing roof bolter operator concentrations underneath the CAC to the concentrations at the rear of the bolter,and finally,(3)using the gravimetric data directly underneath the CAC to correct roof bolter operator concentrations underneath the CAC and comparing them to the concentrations at the rear of the *** 1 dust control efficiencies ranged from 53.9%to 60.4%.Method 2 efficiencies ranged from 150.5%to 52.2%,and Method 3 efficiencies ranged from 40.7%to 91%.Reasons for negative and low dust control efficiencies are provided in this paper and include:incorrect sampling locations,large distance between CAC and operator,and contamination of intake air from line *** dust concentrations encountered during the testing made it difficult to discern whether differences in concentrations were due to the CAC or due to variances inherent in experimental dust ***,the analyses,especially the Method 3 analysis,show that the CAC can be an effective dust control device.

关键词： Coal Roof bolter Respirable dust Underground mining

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Molecular Docking of Bacosides with Tryptophan Hydroxylase:A Model to Understand the Bacosides Mechanism

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Natural Products and Bioprospecting 2014年第4期4卷 251-255页

作者： David Mary Rajathei Jayakumar Preethi Hemant k.singh koilmani Emmanuvel Rajan Department of Bioinformtics Bharathidasan UniversityTiruchirappalli 620024India Department of Animal Science School of Life SciencesBharathidasan UniversityTiruchirappalli 620024India Laboratories of CNS Disorder Learning&MemoryDivision of PharmacologyCentral Drug Research InstituteLucknow 226031India

Tryptophan hydroxylase(TPH)catalyses L-tryptophan into 5-hydroxy-L-tryptophan,which is the first and ratelimiting step of serotonin(5-HT)***,we found that TPH2 up-regulated in the hippocampus of postnatal rats after the oral treatment of Bacopa monniera leaf extract containing the active compound ***,the knowledge about the interactions between bacosides with TPH is *** this study,we take advantage of in silico approach to understand the interaction of bacoside-TPH complex using three different docking algorithms such as HexDock,PatchDock and *** these three algorithms showed that bacoside A and A3 well fit into the cavity consists of active ***,our analysis revealed that major active compounds bacoside A3 and A interact with different residues of TPH through hydrogen ***,Tyr235,Thr265 and Glu317 are the key residues among them,but none of them are either at tryptophan or BH4 binding ***,its note worthy to mention that Tyr 235 is a catalytic sensitive residue,Thr265 is present in the flexible loop region and Glu317 is known to interacts with *** with these residues may critically regulate TPH function and thus serotonin *** study suggested that the interaction of bacosides(A3/A)with TPH might up-regulate its activity to elevate the biosynthesis of 5-HT,thereby enhances learning and memory formation.

关键词： Serotonin Tryptophan hydroxylase Bacosides Docking