Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19:a single-center,retrospective study

作     者：Neeraj Kumar Sarfaraz Ahmad Mala Mahto Abhyuday Kumar Prabhat K.Singh Neeraj Kumar;Sarfaraz Ahmad;Mala Mahto;Abhyuday Kumar;Prabhat K.Singh

作者机构：Department of Trauma and EmergencyAll India Institute of Medical Sciences PatnaBiharIndia Department of AnaesthesiologyAll India Institute of Medical Sciences PatnaBiharIndia Department of BiochemistryAll India Institute of Medical Sciences PatnaBiharIndia DirectorAll India Institute of Medical Sciences PatnaBiharIndia 

出 版 物：《Emergency and Critical Care Medicine》 (急危重症医学（英文）)

年 卷 期：2022年第2卷第3期

页      面：122-127页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Cardiac biomarkers COVID-19 Intensive care unit Mortality Prognosis Retrospective study 

摘      要：Background:The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 in India has been declared a public health *** patients with COVID-19 experience cardiac *** with COVID-19 admitted to the intensive care unit(ICU)with acute myocardial injury showed increased high-sensitivity troponin *** troponin levels may indicate myocardial injury and are commonly associated with ***:We conducted a retrospective observational study of 44 patients with severe COVID-19 in ICU during the second *** primary end point of our retrospective study was 28-day mortality,and the time of ICU admission was designated as day *** extracted and analyzed cardiac biomarkers,such as creatine kinase(CK),creatine kinase-MB(CK-MB),B-type natriuretic peptide(BNP),and high-sensitivity cardiac troponin I(hs-cTnI),and various inflammatory markers such as C-reactive protein(CRP)level,interleukin 6(IL-6),D-dimer,ferritin,lactate dehydrogenase,IL-6,and procalcitonin in patients with severe COVID-19 at ICU admission and 72 hours after ICU admission from our electronic medical record ***:The best cutoff of BNP were 326.8 and 398.5 pg/mL,CK were 195.95 and 180.12 U/L,CK-MB were 112.10 and 108.5 U/L,and hs-cTnI were 0.035 and 0.025 ng/mL,at ICU admission and 72 hours after ICU admission for predicting 28-day mortality among ***:In patients with severe COVID-19,CK and hs-cTnI may be considered effective and valuable predictive cardiac biomarkers among nonsurvivors and predict poor prognosis.