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Investigating the role of imprinted genes in pediatric sporadic brain arteriovenous malformations

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Neural Regeneration Research 2022年第1期17卷 101-102页

作者： Concetta Scimone Luigi Donato antonina Sidoti Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessinaItaly

Arteriovenous malformation AVM is a vascular congenital defect affecting microvasculatu re of both brain and peripheral o rga *** malformation of the brain(bAVM,OMIM#108010),in particular,affects up to 15 per100,000 persons with no sex *** 50%of the patients manifest intracerebral hemorrhage and epileptic seizures,as main clinical symptoms.

关键词： malformation pediatric congenital

Relationship between sleep quality and blood pressure level in nurses performing shift work

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Frontiers of Nursing 2024年第1期11卷 77-84页

作者： antonina Tsipkalo Kateryna Kozak Mariya Marushchak Department of Functional and Laboratory Diagnostics I.Horbachevsky Ternopil National Medical UniversityTernopil 46001Ukraine Department of Pediatrics No.2 I.Horbachevsky Ternopil National Medical UniversityTernopil 46001Ukraine

Objective:The aim of the study was to evaluate the quality of sleep in nurses performing shift work in therapeutic and surgical depar tments and to establish possible relationships between level of blood pressure(BP)and quality of ***:A total of 20 nurses of the therapeutic depar tments and 20 nurses of the surgical depar tments were enrolled in the *** quality was assessed using the Pittsburgh Sleep Quality Index(PSQI).BP was measured according to the standard protocol using the Korotkoff method;a sphygmomanometer was used for this twice with an interval of 2 min between 10:00 *** 10:30 *** average value for the 2 indicators was *** diagnosis of essential ar terial hyper tension(AH)was established according to the recommendations of the European Association of Cardiology and the European Association of Hypertension(2018).Results:The overall assessment of the sleep quality of the nurses involved in shift work indicates poor sleep quality;this was true in respondents of both the surgical and therapeutic ***,it was observed that the quality of sleep was significantly lower in nurses of the therapeutic ***,poor sleep quality was associated with AH,which was diagnosed in 65%of the nurses of the therapeutic departments and 45%of the nurses of the surgical departments,that is,in almost all of the ***,in the nurses of the therapeutic departments,the level of systolic BP exceeded that of the nurses of the surgical ***:Poor sleep quality is a significant risk factor for AH development and is relevant to nurses performing shift *** clinical studies should be conducted to better understand the mechanisms underlying such adverse cardiometabolic outcomes associated with sleep disorders in the health-sector shift workers.

关键词： blood pressure nurses shift work sleep quality Pittsburgh Sleep Quality Index

Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review

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World Journal of Gastroenterology 2014年第13期20卷 3663-3671页

作者： Winfried Huser Gabriele Moser Petra Klose antonina Mikocka-Walus Department of Internal Medicine Ⅰ Klinikum SaarbrückenD-66119 SaarbrückenGermany Department Psychosomatic Medicine and Psychotherapy Technische Universit?t MünchenD-81675 MünchenGermany Department of Internal Medicine Ⅲ Division of Gastroenterology and HepatologyMedical University of Vienna1090 ViennaAustria Department Internal Medicine Ⅴ (Integrative Medicine) Kliniken Essen-MitteEssenD-45276 EssenGermany Department of Health Sciences University of YorkHeslingtonYorkYO105DDUnited Kingdom

AIM: To study statements and recommendations on psychosocial issues as presented in international evidence-based guidelines on the management of inflammatory bowel diseases (IBD).

关键词： Anxiety Depression Guidelines Inflammatory bowel diseases Psychological Psychotherapy Smoking Stress

Peripheral biomarkers for pediatric brain tumors:current advancements and future challenges

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 117-132页

作者： Markus J.Bookland antonina Kolmakova Division of Neurosurgery Connecticut Children’s Medical CenterHartfordCT 06106USA Department of Pediatrics University of Connecticut Health CenterFarmingtonCT 06106USA

Circulating biomarkers - nucleic acids, proteins, and metabolites - have been used in several adult oncologic processes to affect early detection, measure response to treatment, and offer prognostic information. The identification and validation of biomarkers for pediatric brain tumors, however, has been meager by comparison. Early detection and serial screening of pediatric brain tumors has the potential to improve outcomes by allowing for rapid therapeutic interventions and more targeted therapies. This is particular resonant for pediatric brain tumors where treatment success is heavily dependent on early surgical intervention. This highlights the need for biomarker development in pediatric neuro-oncology. The authors reviewed current circulating biomarker targets in various biofluid reservoirs and discuss the current barriers to biomarker development in pediatric neuro-oncology patients.

关键词： Pediatric brain tumor biomarker miRNA biofluid overview

Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第12期21卷 3663-3670页

作者： Réme Mountifield Jane M Andrews antonina Mikocka-Walus Peter Bampton Department of Gastro-enterology and Hepatology Flinders Medical Centre Flinders University of South Australia IBD Service Department of Gastroenterology and Hepatology and School of Medicine University of Adelaide at Royal Adelaide Hospital School of Nursing and Midwifery University of South Australia

AIM: To examine the frequency of regular complementary and alternative therapy(CAM) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological predictors of CAM use across all cohorts. METHODS: A cross sectional questionnaire was administered to inflammatory bowel disease(IBD) patients in 3 separate cohorts which differed by geographical region and care setting. Demographics and frequency of regular CAM use were assessed, along with attitudes towards IBD medication and psychological parameters such as anxiety, depression, personality traits and quality of life(QOL), and compared across cohorts. Independent attitudinal and psychological predictors of CAM use were determined using binary logistic regression analysis. RESULTS: In 473 respondents(mean age 50.3 years, 60.2% female) regular CAM use was reported by45.4%, and did not vary between cohorts. Only 54.1%of users disclosed CAM use to their doctor. Independent predictors of CAM use which confirm those reported previously were: covert conventional medication dose reduction(P < 0.001), seeking psychological treatment(P < 0.001), adverse effects of conventional medication(P = 0.043), and higher QOL(P < 0.001).Newly identified predictors were CAM use by family or friends(P < 0.001), dissatisfaction with patient-doctor communication(P < 0.001), and lower depression scores(P < 0.001). CONCLUSION: In addition to previously identified predictors of CAM use, these data show that physician attention to communication and the patient-doctor relationship is important as these factors influence CAM use. Patient reluctance to discuss CAM with physicians may promote greater reliance on social contacts to influence CAM decisions.

关键词： Complementary medicine Alternative therapy Therapy

Anatomical basis for pancreas transplantation via isolated splenic artery perfusion:A literature review

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World Journal of Clinical Cases 2022年第35期10卷 12844-12853页

作者： Ilya Dmitriev Marine Oganesyan antonina Popova Egor Orlov Mikhail Sinelnikov Yury Zharikov Department of Pancreas and Kidney Transplantation N.V.Sklifosovsky Research Institute for Emergency CareMoscow 107045Russia Department of Human Anatomy Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Oncology Radiotherapy and Reconstructive SurgerySechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of clinical morphology Research Institute of Human MorphologyMoscow 117418Russia

The variability of vascular anatomy of the pancreas underlines the difficulty of its *** regarding the consistency of anatomical variations shows splenic arterial dominance in most *** can significantly improve transplantation success.A systematic literature review was performed according to the quality standards described in the AMSTAR measurement tool and the PRISMA *** valuated existing literature regarding the vascularization and blood perfusion patterns of the pancreas in terms of dominance and *** collected data was independently analyzed by two *** of vascular anatomy was seen to be underreported in literature,though significant findings have been included and discussed in this study,providing valuable insight into the dynamics of pancreatic perfusion and feasibility of transplantation on several different supplying *** splenic artery(SA)has a high percentage of consistency in all found studies(over 90%).High frequency of anastomoses between arterial pools supplying the pancreas can mediate sufficient blood supply through a dominant vessel,such as the SA,which is present in most *** transplantation with isolated SA blood supply can provide sufficient arterial perfusion of the pancreas for stable transplant viability due to high anatomical consistency of the SA and vast communications with other arterial systems.

关键词： Pancreas transplantation Isolated splenic artery supply Pancreas anatomy pancreatic perfusion Minireview

Generalized food-deceptive orchid species flower earlier and occur at lower altitudes than rewarding ones

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Journal of Plant Ecology 2010年第4期3卷 243-250页

作者： Loıc Pellissier Pascal Vittoz antonina Ingrid Internicola Luc Daniel Bienvenu Gigord Department of Ecology and Evolution University of LausanneBiophoreCH-1015 LausanneSwitzerland Faculty of Geosciences and Environment University of LausanneBiophoreCH-1015 LausanneSwitzerland Conservatoire Botanique National de Mascarin 2 rue du Pe`re GeorgesLes Colimac xons97436 Saint-LeuLa Re´unionFrance Present address:Department of Biological Sciences 2500 University Drive N.W.University of CalgaryCalgary ABAlbertaCanada T2N 1N4

Aims Food-deceptive pollination,in which plants do not offer any food reward to their pollinators,is common within the *** food-deceptive orchids are poorer competitors for pollinator visitation than rewarding orchids,their occurrence in a given habitat may be more constrained than that of rewarding *** particular,the success of deceptive orchids strongly relies on several biotic factors such as interactions with co-flowering rewarding species and pollinators,which may vary with altitude and over *** study compares generalized food-deceptive(*** sexually deceptive)and rewarding orchids to test whether(i)deceptive orchids flower earlier compared to their rewarding counterparts and whether(ii)the relative occurrence of deceptive orchids decreases with increasing *** To compare the flowering phenology of rewarding and deceptive orchids,we analysed data compiled from the literature at the species level over the occidental Palaearctic *** flowering phenology can be constrained by the latitudinal distribution of the species and by their phylogenetic relationships,we accounted for these factors in our *** compare the altitudinal distribution of rewarding and deceptive orchids,we used field observations made over the entire Swiss territory and over two Swiss mountain *** Findings We found that deceptive orchid species start flowering earlier than rewarding orchids do,which is in accordance with the hypotheses of exploitation of naive pollinators and/or avoidance of competition with rewarding co-occurring ***,the relative frequency of deceptive orchids decreases with altitude,suggesting that deception may be less profitable at high compared to low altitude.

关键词： altitude timing of flowering food-deception European orchids Orchidaceae biogeography

Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances

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Journal of Pharmaceutical Analysis 2016年第2期6卷 132-136页

作者： Bruno Gallinella Rosella Ferretti Leo Zanitti Isabella Sestili antonina Mosca Roberto Cirilli Istituto Superiore di Sanita Dipartimento del Farmaco Viale Regina Elena 299 1-00161 Rome Italy

A simple analytical high-performance liquid chromatography （HPLC） method was applied for the en- antiomeric excess determination of esomeprazole （（S）-OME）, the enantiopure active ingredient con- tained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase （CSP） under reversed-phase conditions. The results were evaluated and compared with those obtained by the official enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of （S）-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of （S）-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor specificity due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity （R）-OME （impurity F）.

关键词： Chiralpak ID-3 Enantiomers Enantioselective HPLC Impurities(S)-Omeprazole

Diagnostics of Optical Characteristics and Parameters of Gas-Discharge Plasma Based on Mercury Diiodide and Helium Mixture

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Open Journal of Applied Sciences 2015年第12期5卷 826-832页

作者： antonina Malinina Physical Faculty Uzhgorod National University Uzhgorod Ukraine

The results of diagnostics of spectral, temporal and energy characteristics of the radiation of gas-discharge plasma in a mixture of mercury diiodide vapor with helium in the spectral range of 350 - 900 nm, and the plasma parameters in the range of reduced electric field E/N = 1 - 100 Td are presented. The plasma is created in the barrier discharge device with a cylindrical aperture. The electrodes are placed 0.2 m in length at a distance of 0.015 m. The amplitude of the pump pulse, the duration and frequency were 20 - 30 kV, 150 ns and 1 - 20 kHz, respectively. Radiation in the visible region of the spectrum of mercury monoiodide exciplex molecule is revealed. Regu larities in the optical characteristics of the plasma, depending on the partial pressures of the components of the mixture, the electron energy distribution function, mean electron energy, specific losses of discharge power on the process of dissociative excitation of mercury monoiodide (state B2Σ+1/2) molecules as well as the rate constant of dissociative excitation of mercury monoiodide molecules in working mixture depending on the given reduced electric field are established.

关键词： Diagnostics Optical Characteristics Barrier Discharge Gas-Discharge Plasma Mercury Diiodide Inert gases The Plasma Parameters