Peripheral biomarkers for pediatric brain tumors:current advancements and future challenges
作者机构：Division of NeurosurgeryConnecticut Children’s Medical CenterHartfordCT 06106USA Department of PediatricsUniversity of Connecticut Health CenterFarmingtonCT 06106USA
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2019年第4卷第4期
页 面：117-132页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pediatric brain tumor biomarker miRNA biofluid overview
摘 要：Circulating biomarkers - nucleic acids, proteins, and metabolites - have been used in several adult oncologic processes to affect early detection, measure response to treatment, and offer prognostic information. The identification and validation of biomarkers for pediatric brain tumors, however, has been meager by comparison. Early detection and serial screening of pediatric brain tumors has the potential to improve outcomes by allowing for rapid therapeutic interventions and more targeted therapies. This is particular resonant for pediatric brain tumors where treatment success is heavily dependent on early surgical intervention. This highlights the need for biomarker development in pediatric neuro-oncology. The authors reviewed current circulating biomarker targets in various biofluid reservoirs and discuss the current barriers to biomarker development in pediatric neuro-oncology patients.
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