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Anhedonia and functional dyspepsia in obese patients:Relationship with binge eating behaviour

World Journal of Gastroenterology 2020年第20期26卷 2632-2644页

作者： antonella Santonicola Mario Gagliardi Giovanni Asparago Luna Carpinelli Luigi Angrisani Paola Iovino Gastroenterology Unit Department of MedicineSurgery and Dentistry"Scuola Medica Salernitana"University of SalernoBaronissi 84081SalernoItaly General and Endoscopic Surgery Unit San Giovanni Bosco HospitalNaples 80100Italy

BACKGROUND Obese patients(Ob)with a binge eating disorders(BED)behavior pattern have a higher prevalence of postprandial distress syndrome(PDS)compared to Ob without a BED behavior pattern,while an increase of PDS has been described in Ob after sleeve gastrectomy(SG).Hedonic response to a meal is dissociable from satiation in healthy *** is the lowered ability to experience *** are no studies investigating the presence of anhedonia in Ob with and without SG and its relationship to PDS *** To assess the relationship among anhedonia,BED and upper gastrointestinal symptoms in two group of morbidly Ob with and without *** Eighty-one Ob without SG,45 Ob with SG and 55 healthy controls(HC)were *** subjects fulfilled the binge eating scale(BES)to investigate BED,the validated 14 items Snaith-Hamilton pleasure scale(SHAPS)to assess Anhedonia as well as the Beck Depression Inventory-II(BDI II)and State Trait Anxiety Inventory(STAI)questionnaires to screen for depression and *** patients underwent a standardized questionnaire investigating the intensity-frequency scores(0-6)of upper gastrointestinal symptoms and were diagnosed for the presence of functional dyspepsia(FD)and its subtypes according to ROME IV *** Ob without SG who were positive for BED had a 4.7 higher risk of FD compared to Ob without SG who were negative for BED(OR:4.7;95.0%CI 1.23-18.24;P=0.02).STAI-Y2 scores were significantly higher in Ob without SG positive for BED(42.2±1.5 vs Ob negative for BED:39.6±1.0,P=0.04),while SHAPS scores and BDI II did not differ in the two groups(1.16±1.30 vs 0.89±1.02,P=0.49).A lower prevalence of BED(BES>17:11.4%vs 40.7%,P=0.001)and BDI-II(6.8±1.2 vs 13.8±1.9,P=0.005)was reported in Ob with SG than Ob without SG,on the contrary total mean scores of STAI-Y1 and STAI-Y2 were significantly higher in Ob with SG than Ob without ***-five percent of Ob with SG fulfilled the diagnosis of *** mean score

关键词： Morbid obesity Functional dyspepsia Postprandial distress syndrome Epigastric pain syndrome Anhedonia Binge eating disorders Sleeve gastrectomy

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Patient-derived organoids for therapy personalization in inflammatory bowel diseases

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World Journal of Gastroenterology 2022年第24期28卷 2636-2653页

作者： Marianna Lucafò antonella Muzzo Martina Marcuzzi Lorenzo Giorio Giuliana Decorti Gabriele Stocco Advanced Translational Diagnostics Laboratory Institute for Maternal and Child Health-IRCCS“Burlo Garofolo”Trieste 34137Italy Department of Medicine Surgery and Health SciencesUniversity of TriesteTrieste 34127Italy Department of Life Sciences University of TriesteTrieste 34127Italy

Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized *** of IBD pathogenesis is still incomplete,and the most widely-accepted interpretation considers genetic factors,environmental stimuli,uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD,leading to dysfunction of the intestinal epithelial *** vitro models commonly used to study the intestinal barrier do not fully reflect the proper intestinal *** important innovation is represented by organoids,3D in vitro cell structures derived from stem cells that can self-organize into functional organ-specific *** may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic *** models are powerful pharmacological tools to better understand IBD pathogenesis,to study the mechanisms of action on the epithelial barrier of drugs already used in the treatment of IBD,and to evaluate novel target-directed molecules which could improve therapeutic *** aim of this review is to illustrate the potential use of organoids for therapy personalization by focusing on the most significant advances in IBD research achieved through the use of adult stem cells-derived intestinal organoids.

关键词： Inflammatory bowel disease Organoids Intestinal epithelium 3D cell cultures Personalized medicine

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Arterial Stiffness as a Cardiovascular Risk Factor in Prostate Cancer Survivors:A Case-Control Study

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Journal of Science in Sport and Exercise 2021年第2期3卷 171-178页

作者： Lynnette M.Jones Rebekah Wilson Lee Stoner J.Chris baldi School of Physical Education Sportand Exercise SciencesUniversity of OtagoPO Box 56DunedinNew Zealand Department of Sport and Exercise Science University of North CarolinaChapel HillNC 27599-8700USA Department of Medicine University of OtagoPO Box 56DunedinNew Zealand

Purpose In New Zealand,prostate cancer (PCa) is the most commonly diagnosed cancer in men and the third most common cause of male cancer *** these patients,the most common non-cancer related cause of death is cardiovascular disease (CVD).Aortic arterial stiffness may be clinically viable solution for detecting and tracking CVD risk factor in PCa *** aim of the study was to determine whether aortic arterial stiffness is increased in PCa survivors compared to age-matched *** Participants recruited for this prospective comparative study were PCa survivors who had completed treatment(other than endocrine therapy) or were on active surveillance compared,or were age-matched non-cancer *** a single 1-h appointment,all participants had measures of aortic arterial stiffness,arterial wave reflection,central blood pressure and body composition *** Ninety-eight men were recruited,51 PCa survivors and 47 *** was no significant between group dif-ference for aortic arterial stiffness[12.0 m/s (SD:1.7) vs.12.0 m/s (SD:1.9),P=0.953,d=0.0].Fat free mass[60.7 kg(SD:4.9) vs.65.1 kg (SD:8.3),P=0.007,d=0.6]and skeletal muscle index[8.6 kg/m2 (SD:0.6) vs.9.0 kg/m2 (SD:0.9),P=0.050,d=0.5]were lower in the PCa *** Aortic arterial stiffness is not increased (worse) in men with PCa who receive various treatments,compared to age-matched *** findings may indicate that factors other than increased aortic arterial stiffness contribute to heightened risk of cardiovascular events in this population.

关键词： Prostate cancer Cardiovascular disease Risk Arterial stiffness

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High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism

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World Journal of Gastroenterology 2010年第48期16卷 6119-6122页

作者： Matteo Nicola Dario Di Minno antonella Tufano Anna Rusolillo Giovanni Di Minno Giovanni Tarantino Department of Clinical and Experimental Medicine Federico II University Medical School of Naples

AIM:To assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with idiopathic venous thromboembolism (VTE). METHODS:In a case-control study,after excluding subjects with well-consolidated risk factors for VTE,idiopathic VTE was documented in 138 consecutive patients who were referred to our department. Two hundred and seventy-six healthy sex/age/body-massindex-matched subjects,without any clinical/instrumental evidence of VTE,served as controls. All underwent a clinical/laboratory/ultrasound assessment for the presence of metabolic syndrome and NAFLD. RESULTS:NAFLD was detected in 112/138 cases (81%) and in 84/276 controls (30%) [risk ratio:2.7,95% confidence interval (CI):2.2-3.2,P < 0.0001]. Metabolic syndrome and smoking habit were more prevalent in patients with idiopathic VTE. The high prevalence of NAFLD in VTE was also confirmed after adjustment for inherited thrombophilia. NAFLD was clearly predicted by VTE (odds ratio:1.8,95% CI:1.2-2.7,P < 0.0001).

关键词： Thromboembolism Metabolic syndrome Nonalcoholic fatty liver disease

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Additive manufacturing of antibacterial PLA-ZnO nanocomposites:Benefits,limitations and open challenges

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Journal of Materials Science & Technology 2022年第16期111卷 120-151页

作者： Wei Juene Chong Shirley Shen Yuncang Li Adrian Trinchi Dejana Pejak Ilias(Louis)Kyratzis antonella Sola Cuie Wen School of Engineering RMIT UniversityMelbourneVictoria 3001Australia CSIRO Manufacturing Business Unit ClaytonVictoria 3169Australia

Polymeric biomaterials such as polylactic acid(PLA)play a prominent role in the advancement of biomedical additive manufacturing(AM).PLA offers indeed a very advantageous combination of thermomechanical properties and functional attributes,as it is biobased,biodegradable,biocompatible and easy to ***,PLA can be damaged by common sterilization methods and is sensitive to most chemical disinfectants,and this may impair its widespread *** of the most promising ways to overcome this shortcoming is to provide PLA with embedded antibacterial activity by the addition of appropriate fillers such as zinc oxide(Zn O)*** a detailed introduction to the basic properties of PLA and ZnO nanoparticles,the present review analyzes the main variables that govern the antibacterial activity of PLA-ZnO *** applications and related manufacturing processes are also presented to showcase the importance of having embedded antibacterial functions in demanding applications such as food packaging and wound *** is then placed on the emerging literature of the AM of PLA-ZnO nanocomposites,with a focus on fused filament fabrication(also known as fused deposition modeling).Existing gaps and hurdles related to the development and 3D printing of such composites is critically *** is envisioned that a deeper understanding of the processability,thermo-mechanical behavior,biocompatibility and antibacterial efficacy of additively manufactured PLAZnO nanocomposites will foster their adoption in the biomedical field and,ultimately,in all circumstances where it is crucial to limit infection transmission.

关键词： Additive manufacturing Antibacterial activity Fused filament fabrication Nanocomposite PLA ZnO Fused deposition modeling

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Liver involvement in the course of thymoma-associated multiorgan autoimmunity:The first histological description

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 86-89页

作者： Fabrizio Citarella Umberto Vespasiani-Gentilucci Anna Crescenzi antonella Bianchi Vladimir Virzì Giuseppe Tonini Department of Medical Oncology Policlinico Universitario Campus Bio-Medicovia Alvaro del PortilloRome 00128Italy Area of Internal Medicine Unit of HepatologyPoliclinico Universitario Campus Bio-Medicovia Alvaro del PortilloRome 00128Italy Unit of Pathology Policlinico Universitario Campus Bio-Medicovia Alvaro del PortilloRome 00128Italy

To the Editor:Thymoma-associated multiorgan autoimmunity(TAMA)is a rare paraneoplastic syndrome described in patients with thymoma and characterized by multiorgan failure and graft-versus-host dis-ease(GVHD)like pathology affecting the skin,the gastrointestinal tract,and the *** date,only 21 cases are reported in liter-ature[1],with some patients presenting gastrointestinal and hep-atic manifestations,mainly colitis,diarrhea,and abnormal liver en-zymes,but the hepatic involvement has not been histologically characterized yet.

关键词： involvement gastrointestinal diarrhea

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Occurrence and patterns of nutritional traits and polycyclic aromatic hydrocarbons(PAHs)in sea cucumber(Holothuria poli)tissues:benefits and risk for human health

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Food Quality and Safety 2022年第2期6卷 287-309页

作者： Francesca Biandolino Isabella Parlapiano Lucia Spada antonella Di Leo Maria Calo Giovanni Fanelli Ermelinda Prato Santina Giandomenico CNR-IRSA National Research CouncilWater Research Institute--Via Roma 3TarantoItaly

Objectives:The paper evaluates the benefit and risk for human health associated with consumption of sea cucumber Holothuria poli(*** from Italian coasts(Central Mediterranean Sea).Materials and Methods:Body wall(BW),internal tunic(ITu),muscle bands(MBs),alimentary canal(AC),gonad(Gd),and respiratory tree(RT)of *** were analyzed for proximate ***,amino acids(AAs),fatty acids(FAs)and polycyclic aromatic hydrocar bons(PAHs)were determined with high-performance liquid chromatography coupled with ultraviolet-visible spectroscopy(UPLC UV/Vis),gas chromatography-flame ionization detector(GC-FID)and gas chromatography mass spectrometry(GC-MS),***:Differences in the contents of total amino acids(TAAs)occurred based on tissue and sex,with AC and MB of female and Gd of male showing higher contents(range 47.8-60.2 g/kg we weight(ww)).Glycine and glutamic acid were the most *** fatty acid(PUFA)was the major class of FAs and arachidonic acid and eicosapentenoic acid(EPA)were the predominant PUFA.n-3 PUFA showed higher content in Gd,AC,and RT,indicating higher quality.A favorable n-3/n-6 in the range of 1.04-1.67 was *** showed values ranging from 23 to 207μg/kg ww with the highest levels in Gd and AC tissues and the lower in ***[alpyrene,the most toxic compound,was detected in all tissues,of both sexes,at levels of 1.5-18μg/kg ***:All tissues of ***,although with differences among them,are valuable food and can contribute for a healthy *** cancer risk(CR)values for Gd and AC tissues were above the considerable CR threshold of one in 10000 established by the United States Environmental Protection Agency(USEPA)for high ingestion rate of this seafood.

关键词： Holothuria poli,nutitional quality polycyclic aromatic hydrocarbons risk assessment estimated weekly intake cancer risk

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Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection

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World Journal of Gastroenterology 2017年第10期23卷 1764-1770页

作者： Fabio Marongiu Michela Marongiu antonella Contini Monica Serra Erika Cadoni Riccardo Murgia Ezio Laconi Experimental Medicine Unit Department of Biomedical SciencesUniversity of Cagliari09124 CagliariItaly

To address to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue *** ability of the liver to regenerate is remarkable on both clinical and biological grounds. Basic mechanisms underlying this process have been intensively investigated. However, it is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system. We were able to follow the fate of single transplanted hepatocytes during the regenerative response elicited by 2/3 partial surgical hepatectomy (PH) in rats. Clusters of transplanted cells were 3D reconstructed and their size distribution was evaluated over time after *** size and liver DNA content were largely recovered 10 d post-PH, as expected (e.g., total DNA/liver/100 g b.w. was 6.37 ± 0.21 before PH and returned to 6.10 ± 0.36 10 d after PH). Data indicated that about 2/3 of the original residual hepatocytes entered S-phase in response to PH. Analysis of cluster size distribution at 24, 48, 96 h and 10 d after PH revealed that about half of the remnant hepatocytes completed at least 2 cell cycles. Average size of hepatocytes increased at 24 h (248.50 μm2 ± 7.82 μm2, P = 0.0015), but returned to control values throughout the regenerative process (up to 10 d post-PH, 197.9 μm2 ± 6.44 μm2, P = 0.11). A sizeable fraction of the remnant hepatocyte population does not participate actively in tissue mass *** stands as the major mechanism contributing to liver mass restoration after PH, with hypertrophy playing a transient role in the process.

关键词： Liver regeneration Hypertrophy Hyperplasia

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Characterisation of Photocathodes Based on Pb Thin Film Deposited by UV Pulsed Laser Ablation

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Journal of Materials Science & Technology 2014年第1期30卷 37-40页

作者： Francisco Gontad antonella Lorusso Giancarlo Gatti Massimo Ferrario Laura Gioia Passione Luana Persano Nicola Lovergine Alessio Perrone Istituto Nazionale di Fisica Nucleare e Università del Salento Università del Salento Dipartimento di Matematica e Fisica "E.De Giorgi" Laboratori Nazionali di Frascati Istituto Nazionale di Fisica Nucleare Center for Biomolecular Nanotechnologies Istituto Italiano di Tecnologia Dipartimento di Ingegneria dell'Innovazione Università del Salento National Nanotechnology Laboratory(NNL)

This work deals with the deposition of lead （Pb） thin films by the UV pulsed laser ablation technique, for their further use as photocathode devices in superconducting radio frequency guns. Scanning electron microscopy and atomic force microscopy analyses were performed to study the morphological features of Pb thin films deposited on Si （100） and Nb substrates. The films showed a granular structure with a nearly fully covered surface only for that one deposited on Nb substrate. X-ray diffraction measurements indicate the growth of polycrystalline Pb thin films with a preferential orientation along （111） planes. Results of the photoemission performance of Pb thin film deposited on Nb substrate showed a very encouraging average value of quantum efficiency of 6 x 10-5 through a single-photon absorption process, promoting further studies in the realisation of Pb photocathodes by this technique.

关键词： Pulsed laser deposition Lead thin film Metallic photocathodes Quantum efficiency

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Precision medicine in gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 804-829页

作者： Patrizia Bonelli antonella Borrelli Franca Maria Tuccillo Lucrezia Silvestro Raffaele Palaia Franco Maria Buonaguro Molecular Biology and Viral Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Abdominal Medical Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Gastro-pancreatic Surgery Division Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy

Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic *** represents the second leading cause of cancer-related deaths *** onset is subtle,and the majority of patients are diagnosed once the cancer is already *** recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular *** to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic *** the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this *** phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic ***,the heterogeneity of this neoplasia makes the practical application of such approaches ***,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in *** continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate *** several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially ***,surgical resection with adjuvant or neoadjuvant radiotherapy and ch

关键词： Gastric cancer Molecular characterization Biomarkers Precision medicine Targeted therapy

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