Anhedonia and functional dyspepsia in obese patients:Relationship with binge eating behaviour

作     者：Antonella Santonicola Mario Gagliardi Giovanni Asparago Luna Carpinelli Luigi Angrisani Paola Iovino 

作者机构：Gastroenterology UnitDepartment of MedicineSurgery and Dentistry"Scuola Medica Salernitana"University of SalernoBaronissi 84081SalernoItaly General and Endoscopic Surgery UnitSan Giovanni Bosco HospitalNaples 80100Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第20期

页      面：2632-2644页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Morbid obesity Functional dyspepsia Postprandial distress syndrome Epigastric pain syndrome Anhedonia Binge eating disorders Sleeve gastrectomy 

摘      要：BACKGROUND Obese patients(Ob)with a binge eating disorders(BED)behavior pattern have a higher prevalence of postprandial distress syndrome(PDS)compared to Ob without a BED behavior pattern,while an increase of PDS has been described in Ob after sleeve gastrectomy(SG).Hedonic response to a meal is dissociable from satiation in healthy *** is the lowered ability to experience *** are no studies investigating the presence of anhedonia in Ob with and without SG and its relationship to PDS *** To assess the relationship among anhedonia,BED and upper gastrointestinal symptoms in two group of morbidly Ob with and without *** Eighty-one Ob without SG,45 Ob with SG and 55 healthy controls(HC)were *** subjects fulfilled the binge eating scale(BES)to investigate BED,the validated 14 items Snaith-Hamilton pleasure scale(SHAPS)to assess Anhedonia as well as the Beck Depression Inventory-II(BDI II)and State Trait Anxiety Inventory(STAI)questionnaires to screen for depression and *** patients underwent a standardized questionnaire investigating the intensity-frequency scores(0-6)of upper gastrointestinal symptoms and were diagnosed for the presence of functional dyspepsia(FD)and its subtypes according to ROME IV *** Ob without SG who were positive for BED had a 4.7 higher risk of FD compared to Ob without SG who were negative for BED(OR:4.7;95.0%CI 1.23-18.24;P=0.02).STAI-Y2 scores were significantly higher in Ob without SG positive for BED(42.2±1.5 vs Ob negative for BED:39.6±1.0,P=0.04),while SHAPS scores and BDI II did not differ in the two groups(1.16±1.30 vs 0.89±1.02,P=0.49).A lower prevalence of BED(BES17:11.4%vs 40.7%,P=0.001)and BDI-II(6.8±1.2 vs 13.8±1.9,P=0.005)was reported in Ob with SG than Ob without SG,on the contrary total mean scores of STAI-Y1 and STAI-Y2 were significantly higher in Ob with SG than Ob without ***-five percent of Ob with SG fulfilled the diagnosis of *** mean score