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Pan-cancer tumor-infiltrating T cells: A great hallmark in cancer immunology research

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Chinese Journal of Cancer Research 2022年第2期34卷 115-116页

作者： anqiang wang Zhaode Bu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal CancerPeking University Cancer Hospital&InstituteBeijing 100142China

As one of the most promising tools for deep analyses of tumor characteristics, single-cell RNA sequencing(sc RNAseq) is well welcomed for the great advantages of analyzing tumor features at single cell levels(1). Howe... 详细信息

关键词： cancer tumor infiltrating

Bioactive compounds in Hericium erinaceus and their biological properties:a review

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Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang Robert J.Linhardt Xingli wang anqiang Zhang College of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech Co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active components in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive compounds Biological activities Antioxidation Neuroprotection Immunoregulation

Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer

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Chinese Journal of Cancer Research 2019年第6期31卷 945-954页

作者： anqiang wang Zhongwu Li Qian wang Yali Bai Xin Ji Tao Fu Ke Ji Yanwen Xue Tingxu Han Xiaojiang Wu Ji Zhang Yingjie Yang Guobin Xu Zhaode Bu Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China Cyttel Biosciences INC Taizhou 225316China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Clinical LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/***:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were *** study then included 105 gastric cancer patients for *** defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC *** also compared the diagnosis value and peritoneal recurrence predictive value among different detection *** comparison of IFCC number was also conducted among different ***:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our *** to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using *** compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of ***:Gastric cancer could be effectively diagnosed by *** IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of *** is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer.

关键词： NEimFISH gastric cancer peritoneal metastasis conventional cytology intraperitoneal free cancer cells

Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 414-424页

作者： Jianzhen Lin Xu Yang Junyu Long Songhui Zhao Jinzhu Mao Dongxu wang Yi Bai Jin Bian Lei Zhang Xiaobo Yang anqiang wang Fucun Xie Weiwei Shi Huayu Yang Jie Pan Ke Hu Mei Guan Lin Zhao Li Huo Yilei Mao Xinting Sang Kai wang Haitao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)Beijing 100730China OrigiMed Shanghai 200135China Department of Gastrointestinal Surgery Peking University Cancer Hospital&InstituteBeijing 100142China Department of Radiology Peking Union Medical College HospitalBeijing 100730China Center of Radiotherapy Peking Union Medical College HospitalBeijing 100730China Department of Medical Oncology Peking Union Medical College HospitalBeijing 100730China Department of Nuclear Medicine Peking Union Medical College HospitalBeijing 100730China

Background:A therapeutic strategy involving combined treatment with lenvatinib plus pembrolizumab(LEP)has demonstrated a relatively high antitumor response in several solid tumors;however,the efficacy and safety of LEP in patients with refractory bile tract carcinoma(BTC)remains ***:This is a single-arm study for a preliminary assessment of the efficacy and tolerability of LEP in patients who experienced progression from prior systemic ***-treatment tumor tissues were collected to retrospectively evaluate the expression status of ***:Thirty-two patients received second-line and above treatment with ***,the objective response rate(ORR)was 25%,the disease control rate(DCR)was 78.1%,and the clinical benefit rate(CBR)was 40.5%.The median progression-free survival(PFS)was 4.9 months(95%CI:4.7–5.2 months),and the median overall survival(OS)was 11.0 months(95%CI:9.6–12.3 months).For tolerability,no grade 5 serious adverse events(AEs)were *** patients had any-grade AEs,and 59.3%of the patients experienced grade 3 AEs,while only 1 patient experienced a grade 4 AE of stomach *** was the most common AE,followed by hypertension and elevated aminotransferase *** analysis for PDL1 expression revealed that PDL1 positive tumor cells were associated with improved clinical benefits and survival ***:LEP is a promising alternative as a non-first-line therapeutic regimen for patients with refractory ***,well-designed prospective clinical trials with a control arm are still needed to obtain more evidences to confirm the efficacy and safety of this particular regimen as well as the role of PDL1 expression.

关键词： Pembrolizumab lenvatinib bile tract cancer PD1 PDL1

Polyphenol-rich extract from Sanghuangporous vaninii against acetaminophen-induced liver injury by blocking ferroptosis via NRF2/GPX4 pathway

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Food Science and Human Wellness 2024年

作者： Peng Liu Yuyang wang Wanchao Chen Di Wu Zhong Zhang Zhengpeng Li anqiang Zhang Wen Li Yan Yang Institute of Edible Fungi， Shanghai Academy of Agricultural Sciences， National Engineering Research Center of Edible Fungi， Key Laboratory of Edible Fungi Resources and Utilization (South)， Ministry of Agriculture College of Food Science & Technology， Shanghai Ocean University College of Food Science and Engineering， Zhejiang University of Technology

Acetaminophen (APAP) used as an antipyretic and analgesic agent can cause acute liver injury (AILI) under overdose. Sanghuangporous vaninii (S. vaninii) is a edible fungus with abundant metabolites exhibits excellent hepatoprotective activities， but the effect for AILI is not yet fully understood. In this study， the polyphenol-rich extract from S. vaninii (PSV) was prepared， with a total phenolic content of 75.72% and 34 compounds. The data of hepatoprotection indicated that PSV obviously alleviated the hepatocellular injury induced by APAP in vivo and in vitro. The protective mechanism of PSV against APAP-induced AILI might be attributed to the activating NRF2/GPX4 pathway. Based on network pharmacology analysis， the active components of PSV such as caffeic acid， osmundacetone and hispolone played a key role in hepatoprotection of PSV. Consequently， this study highlights the protection of PSV on AILI， which provides new insight into bioactivities of S. vaninii.

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Preparation and Properties of Rare Earth Modified Carbon Black/Natural Rubber Composites

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Journal of Rare Earths 2005年第6期23卷 720-720页

作者： Lin Yaling Xiao Kongqing Zhang anqiang wang Lianshi Department of Polymer Material Science and Engineering South China University of Technology Guangzhou 510640 China

The oxides Eu, Ho, Er and Dy were used to prepare the hydroxides of rare earth modified carbon black. Then natural rubber latex （NRL） was added into the reactor. The system reacted at 85 ℃ with stirring for 1 h to prepare powdered HAF-Ln（OH）3/NR composites. The effects of the kind and content of Ln on the particle size distribution of P [ NR/HAF-Ln （OH）3 ] and mechanical properties of its vulcanizate were studied respectively. It is found that rare earth can help to get the powder of the composite, the product particle with a diameter less than 0.9mm will be get when the composites containing the compound of Ho, Er and Dy with dosage of 1.0, 1.0, O. 5 percent, respectively. The adding of Ln can improve the tensile strength and tear strength of the vulcanizate effectively, what＇s more, Er and Dy can decrease the permanent set of vulcanizate significantly. The SEM studies shows that P[ NR/HAF-Dy （OH）3 ] vulcanizate shows superior mechanical properties that depend primarily on the absence of free carbon black, the fine dispersion of carbon black in the rubber matrix and better polymer-filler interaction.

关键词： polymer material natural rubber carbon black rare earth oxide vulcanizate mechanical property

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基于灰狼算法的抗干扰跳频序列设计

信号处理 2021年第6期37卷 1046-1054页

作者：赵知劲王安强尚俊娜王李军杭州电子科技大学通信工程学院浙江杭州310018 中国电子科技集团第36研究所通信系统信息控制技术国家级重点实验室浙江嘉兴314001

为了提高跳频通信系统的抗干扰能力,本文提出一种结合干扰信息综合考虑跳频序列的汉明相关性、均匀性、被干扰概率和跳频增益的抗干扰跳频序列优化设计方法。使用改进灰狼算法求解优化问题,提出新型反向学习策略和使用莱维飞行的个体信... 详细信息

为了提高跳频通信系统的抗干扰能力,本文提出一种结合干扰信息综合考虑跳频序列的汉明相关性、均匀性、被干扰概率和跳频增益的抗干扰跳频序列优化设计方法。使用改进灰狼算法求解优化问题,提出新型反向学习策略和使用莱维飞行的个体信息交流机制,提升灰狼算法性能。通过基本测试函数的仿真实验表明本文的改进灰狼算法比其他灰狼算法有更好的收敛速度和求解精度。本文的抗干扰跳频序列优化设计结果表明,在多种干扰情况下,本文方法设计的跳频序列相比于传统跳频序列和宽间隔跳频序列具有更强的抗干扰能力。

关键词：抗干扰跳频序列灰狼算法反向学习信息交流

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荷叶在水下的超疏水状态的寿命测试与分析

科学通报 2016年第7期61卷 735-739页

作者：侯绍行王峰会黄建业王安强西北工业大学工程力学系西安710129

水下超疏水现象在金属防腐蚀保护、减阻和防止水下污垢等方面具有重要的应用价值.水下超疏水状态的寿命是制约超疏水材料在水下应用的重要因素.本文通过连续记录超疏水界面处反射光光强变化测试了荷叶在不同水深下的超疏水状态的寿命.... 详细信息

水下超疏水现象在金属防腐蚀保护、减阻和防止水下污垢等方面具有重要的应用价值.水下超疏水状态的寿命是制约超疏水材料在水下应用的重要因素.本文通过连续记录超疏水界面处反射光光强变化测试了荷叶在不同水深下的超疏水状态的寿命.荷叶在水下的润湿状态随时间变化可分为3个阶段:非润湿阶段、部分润湿阶段、完全润湿阶段.非润湿阶段持续的时间即是水下超疏水状态的寿命,随水深的升高呈指数下降,在水深高于毛细力所能抵抗的极限深度时寿命又进一步缩短.气液界面的稳定依靠毛细力产生的悬挂力和空气内部压力共同维持.提高毛细力所能抵抗的极限水深可以使超疏水材料在更深的水域下得到应用.

关键词：水下超疏水寿命全反射毛细力

基于PLC控制技术的桥门式起重机挠度自动化检测

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机械制造与自动化 2023年第2期52卷 135-138页

作者：王安强河南省特种设备检验技术研究院濮阳分院河南濮阳457000

对桥门式起重机的挠度载荷值进行计算时,存在额定条件下检测精度过低的问题,故研究基于PLC控制技术的桥门式起重机挠度自动化检测方法。对应桥门式起重机运行结构,按照主梁的自身质量和小车驱动情况,获取均布载荷值和集中受力值;基于PL... 详细信息

对桥门式起重机的挠度载荷值进行计算时,存在额定条件下检测精度过低的问题,故研究基于PLC控制技术的桥门式起重机挠度自动化检测方法。对应桥门式起重机运行结构,按照主梁的自身质量和小车驱动情况,获取均布载荷值和集中受力值;基于PLC技术构建自动化检测模型,选择Q/E闭环监测模式,计算电机控制过程中的变频容量,对桥门式起重机的挠度进行自动化检测。实验结果表明:在跨内挠度检测过程中本方法最大误差值为0.10 mm;以P4测试点为起重机主梁中点,进行跨中挠度检测,本方法挠度检测误差可控制在0.12 mm范围内,说明本方法的检测精度更高。

关键词：桥门式起重机自动化检测 PLC控制技术起重机挠度