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Expression pattern analysis of odorant-binding proteins in the pea aphid Acyrthosiphon pisum

Insect Science 2015年第2期22卷 220-234页

作者： Filomena De Biasio Lea Riviello Daniele Bruno annalisa Grimaldi Terenzio Congiu Yu Feng Sun Patrizia Falabella Dipartimento di Scienze Universit& della Basilicata via dell' Ateneo Lucano 10 85100 Potenza Dipartimento di Biotecnologie e Scienze della Vita Universita dell'lnsubria via J. H. Dunant 3 21100 Dipartimento di Scienze Chirurgiche e Morfologiche Universita dell'Insubriavia Monte Generoso 321100Varese Italy Chinese Academy of Agricultural Sciences institute of Plant Protection Beijing China

Odorant-binding proteins （OBPs） are soluble proteins mediating chemorecep- tion in insects. In previous research, we investigated the molecular mechanisms adopted by aphids to detect the alarm pheromone （E）-fl-farnesene and we found that the recogni- tion of this and structurally related molecules is mediated by OBP3 and OBP7. Here, we show the differential expression patterns of 5 selected OBPs （OBP 1, OBP3, OBP6, OBPT, OBPS） obtained performing quantitative RT-PCR and immunolocalization experiments in different body parts of adults and in the 5 developmental instars, including winged and unwinged morphs, of the pea aphid Acyrthosiphon pisum. The results provide an overall picture that allows us to speculate on the relationship between the differential expression of OBPs and their putative function. The expression of OBP3, OBP6, and OBP7 in the antennal sensilla suggests a ehemosensory fimction for these proteins, whereas the con- stant expression level of OBP8 in all instars could suggest a conserved role. Moreover, OBP1 and OBP3 are also expressed in nonsensory organs. A light and scanning electron microscopy study of sensilla on different body parts of aphid, in particular antennae, legs, mouthparts, and coruicles-cauda, completes this research providing a guide to facilitate the mapping of OBP expression profiles.

关键词： aphids chemosensilla immunohistochemistry microscopy odorant-binding protein (OBP)

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Diarrhea in neonatal intensive care unit

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World Journal of Gastroenterology 2010年第21期16卷 2664-2668页

作者： annalisa Passariello Gianluca Terrin Maria Elisabetta Baldassarre Mario De Curtis Roberto Paludetto Roberto Berni Canani Department of Pediatrics University of Naples "Federico Ⅱ"Naples80131Italy Department of Evolutive Age Biomedicine University of BariBari70124Italy Neonatal Care Unit University La SapienzaRome00161Italy European Laboratory for Investigation on Food-Induced Diseases University of Naples "Federico Ⅱ"Naples80131Italy

AIM:To investigate the frequency,etiology,and current management strategies for diarrhea in ***:Retrospective,nationwide study involving 5801 subjects observed in neonatal intensive care units during 3 *** main anamnesis and demographic characteristics,etiology and characteristics of diarrhea,nutritional and therapeutic management,clinical outcomes were ***:Thirty-nine cases of diarrhea(36 acute,3 chronic) were *** occurrence rate of diarrhea was 6.72 per 1000 hospitalized *** was defined in 29 of 39 newborn(74.3%):food allergy(20.5%),gastrointestinal infections(17.9%),antibiotic-associated diarrhea(12.8%),congenital defects of ion transport(5.1%),withdrawal syndrome(5.1%),Hirschsprung's disease(2.5%),parenteral diarrhea(2.5%),cystic fibrosis(2.5%),and metabolic disorders(2.5%).Three patients died due to complications related to diarrhea(7.7%).In 19 of 39 patients(48.7%),rehydration was performed exclusively by the enteral ***:Diarrhea in neonates is a challenging clinical condition due to the possible heterogeneous etiologies and severe *** guidelines are advocated in order to optimize management of diarrhea in this particular setting.

关键词： Chronic diarrhea Congenital diarrhea Food allergy Oral rehydration solution Rotavirus

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A Theoretical Overview of Bioresponse to Magnetic Fields on the Earth’s Surface

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International Journal of Geosciences 2014年第10期5卷 1149-1162页

作者： Pietro volpe Department of Biology of the “Tor Vergata” University of Rome Rome Italy

This survey points to the mechanisms of bioresponse caused by magnetic fields (MFs), paying attention to their action not only on ions, molecules and macromolecules, but also on cells, tissues and organisms. The significance of findings concerning the MF-dependence of cell proliferation, necrosis or apoptosis was judged by comparing the results obtained in a solenoid, where an MF can be added to the geomagnetic field (GMF), with those obtained in a magnetically shielded room, where the MFs can be attenuated or null. This comparative criterion was particularly appropriate when the differences detectable between the data provided by experimental samples and the data provided by control samples were rather small, as observed in estimating the MF-influence on total DNA replication, RNA transcription and polypeptide translation. The MF-induced inhibition of apoptosis was considered as a risk potentially leading to accumulation of cancer cells. The analysis also surveyed the MF-dependence of the interactions between host animal cells and infecting bacteria. In relation to studies on the origin and adaptation of life on the Earth, theoretical insights paving the way to elucidating the MF-interactions with biostructures and biosystems of different orders of organization evaluated the possible involvement of the so-called “biological windows”. Analogously to what is known for ionizing radiations, the efficiency of the applied MFs appeared to depend on the complexity of their biological targets.

关键词： Magnetic Fields vs. Living Matter Biological Windows Biodysfunctions Apoptosis vs. Neoplasia

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Birthing Systems, Bio-medicine and Gender-Based PowerRelationships: Patrilinearity and Childbirth in Amed(Est Bali, Indonesia)

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Cultural and Religious Studies 2020年第1期8卷 45-52页

作者： annalisa Garzonio University of Insubria VareseItaly

This article offers an anthropological overview about birth processes in a small village in Bali.I would like to investigate how the naturalization of this event is often used to justify control over the physical and social body of women,their descendants and social *** focus of the analysis will be the consideration of how women’s position within society is determined by a complex system of rules,values,and medical practices deeply conditioning childbirth sphere that legitimates hierarchical divisions and gender inequality.

关键词： anthropology of childbirth patriarchal system gender-based power relationship biomedicine

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＂The Man Was Dead and so He Had to Kill the Things He Loved＂：＂Medusation＂ as Metatheatre in Eugene O＇Neill＇s Mature Plays

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Journal of Literature and Art Studies 2011年第1期1卷 1-8页

作者： annalisa Brugnoli University of Venice Veneto Italy

This study is about Eugene O＇Neill＇s use of ＂medusation＂ as an effective metatheatrical device and foremost achievement in his art. Occurring onstage as an unexpected ＂anagnorisis＂, the medusation is a traumatic experience that engenders ritual death. This author argues that the medusation is a quintessentially metatheatrical act, insomuch as here O＇Neill carries out a commentary on the function and functioning of theatre, through the consciously fictitious events that unfold on the stage. In the ＂Introduction＂, the author reviews its development in O＇Neill＇s plays, from the more traditional melodramatic situations of the early works to the subsequent portrayal of a self-defeating pattern calling for psychological violence and symbolic death. In the section called ＂Medusation＂, the author addresses the concept of medusation in order to account for the process whereby O＇Neill＇s people, annihilated by their sudden glimpses into the other within themselves, undergo major physical and spiritual change In ＂Case Studies＂, the author analyzes the chief correlatives of medusation： the dead-in-life, the death mask and the dead double. The author＇s point in this paper is, thus, to show how extensively and pervasively O＇Neill deploys medusation in order to signify a rite of passage that engenders metatheatrical death. Its outcome may either be the perpetuation of an endless spiral of violence and self-defeat, or a premise for rebirth arising from the characters＇ assumption of responsibility as to their share of guilt in the evil of the world, together with the renewed human sympathy and understanding that this awareness brings along

关键词： Eugene O'Neill medusation metatheater theater American drama

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Deficit of pursuit ocular movements in early Alzheimer's disease

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Neural Regeneration Research 2010年第20期5卷 1583-1586页

作者： Francesco Cordici Pietro Lanzafame Silvia Marino Alessandro Celona Lilla Bonanno annalisa Baglieri Alessia Bramanti Placido Bramanti IRCCS Centro Neurolesi "Bonino-Pulejo" S.S. Via Palermo C.da Casazza 98124 Messina Italy

Previous studies have demonstrated that advanced Alzheimer＇s disease（AD）patients have deficiency of eye ***,there have been no reports on eye movement in the early stages of *** aim of this study was to evaluate pursuit ocular movements（POM）provided by a vision-based non-intrusive eye tracker in patients with early *** values were significantly lower in AD patients than in normal controls（P 〈 0.01）.In AD patients,POM values were not closely correlated with the Mini-Mental State Examination scores（P = 0.3）.There was no significant difference in POM values among patients treated with or without anticholinesterase *** used a vision-based method,for non-intrusive eye tracking,which can be proposed as a possible tool for supporting the diagnosis of early AD.

关键词： Alzheimer's disease early diagnosis pursuit ocular movements smooth pursuit dysfunctions vision-based eye tracking system

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Structural investigation of Rett-inducing MeCP2 mutations

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Genes & Diseases 2019年第1期6卷 31-34页

作者： Ottavia Spiga Simone Gardini Nicole Rossi Vittoria Cicaloni Francesco Pettini Neri Niccolai annalisa Santucci Department of Biotechnology Chemistry and PharmacyUniversity of SienaSiena53100Italy GenomeUp SRL Rome00199Italy Toscana Life Sciences Foundation(TLS) Siena 53100Italy

X-ray structure of methyl-CpG binding domain(MBD)of MeCP2,an intrinsically disordered protein(IDP)involved in Rett syndrome,offers a rational basis for defining the spatial distribution for most of the sites where mutations responsible of Rett syndrome,RTT,*** have ascribed pathogenicity for mutations of amino acids bearing positively charged side chains,all located at the protein-DNA interface,as positive charge removal cause reduction of the MeCP2-DNA adduct *** of the frequent proline replacements,outside the DNA contact moiety of MBD,can be attributed to the role of this amino acid for maintaining both unfolded states for unbound MeCP2 and,at the same time,to favor some higher conformational order for stabilizing structural determinants required by protein *** hypotheses can be extended to transcription repressor domain,TRD,the other MeCP2-DNA interaction site and,in general,to all the IDP that interact with nucleic acids.

关键词： DNA binding domains MeCP2 Mutation distribution Protein structure Rett syndrome

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Opportunities from ICT for Agro-Food Supply Chains

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Computer Technology and Application 2011年第2期2卷 127-136页

作者： FlavioBoccia Tiziana volpe ＂Parthenope ＂ University of Naples （Economics Department）＆ National Research Council Naples 40-80133 Italy

Nowadays the situation of agro-food and rural sector in terms of markets, development and competitiveness and the specific impact that rural activities have in the society, added to the potential positive impact of new ICT technologies, has arisen new challenges. Support the European Agro-food industry to be a worldwide leader in the supply of high quality and safe food products. The relevance of agro-food industry is not only related to its importance in European economy but also is consequence of increase awareness concerning to the necessity of producing high quality and safe products. The implementation of the new technologies in agro-food domain, enabling adequate combination of traditional products and modern management processes will definitively contribute to produce high quality and safe products. Increase the level of involvement of consumers in the agro-food value chain by means of the wide adoption of relevant IC Technologies and applications. The agro-food sector is very much a consumer driven sector. However, in order to realise the full participation of citizens in the whole agro-food supply chain, further developments in ICTs are required. The incorporation of ICT tools will greatly contribute to achieving a deeper integration, communication and information flow between the different stakeholders in the supply chain, from ＂fork to farm＂, from farmers to consumers. Therefore, in first place the objective of the work is to analyze the opportunities offered by the ICT to implement the systems of traceability in the food system. In according to place the study wants to deepen the norm ISO22000, in which the ICT has a fundamental role to have a synthetic tool of guarantee and greater trust for the consumer. The purpose is to make a critical review of the existing literature on this matter in relationship to the agro-food systems.

关键词： Food information and communications technology (ICT) ISO quality traceability.

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Lumen-apposing metal stents for malignant biliary obstruction: Is this the ultimate horizon of our experience?

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World Journal of Gastroenterology 2019年第29期25卷 3857-3869页

作者： Andrea Anderloni Edoardo Troncone Alessandro Fugazza annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Digestive Endoscopy Unit Division of Gastroenterology Humanitas Research Hospital Milan 20089 Italy Department of Systems Medicine University of Rome “Tor Vergata” Rome 00133 Italy Digestive Endoscopy Unit Division of Gastroenterology Humanitas University Milan 20089 Italy

In the last years, endoscopic ultrasonography (EUS) has evolved from a purely diagnostic technique to a more and more complex interventional procedure, with the possibility to perform several type of therapeutic interventions. Among these, EUS-guided biliary drainage (BD) is gaining popularity as a therapeutic approach after failed endoscopic retrograde cholangiopancreatography in distal malignant biliary obstruction (MBO), due to the avoidance of external drainage, a lower rate of adverse events and re-interventions, and lower costs compared to percutaneous trans-hepatic BD. Initially, devices created for luminal procedures (e.g., luminal biliary stents) have been adapted to the new trans-luminal EUSguided interventions, with predictable shortcomings in technical success, outcome and adverse events. More recently, new metal stents specifically designed for transluminal drainage, namely lumen-apposing metal stents (LAMS), have been made available for EUS-guided procedures. An electrocautery enhanced delivery system (EC-LAMS), which allows direct access of the delivery system to the target lumen, has subsequently simplified the classic multi-step procedure of EUS-guided drainages. EUS-BD using LAMS and ECLAMS has been demonstrated effective and safe, and currently seems one of the most performing techniques for EUS-BD. In this Review, we summarize the evolution of the EUS-BD in distal MBO, focusing on the novelty of LAMS and analyzing the unresolved questions about the possible role of EUS as the first therapeutic option to achieve BD in this setting of patients.

关键词： Interventional endoscopic ultrasonography Endoscopic ultrasonography-guided biliary drainage Endoscopic ultrasonography-guided choledocho-duodenostomy Biliary metal stent Lumen-apposing metal stent

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The Yin-Yang of osteopontin in nervous system diseases: damage versus repair

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Neural Regeneration Research 2021年第6期16卷 1131-1137页

作者： Giuseppe Cappellano Domizia Vecchio Luca Magistrelli Nausicaa Clemente Davide Raineri Camilla Barbero Mazzucca Eleonora Virgilio Umberto Dianzani annalisa Chiocchetti Cristoforo Comi Department of Health Sciences Interdisciplinary Research Center of Autoimmune Diseases(IRCAD)University of Piemonte OrientaleNovaraItaly Center for Translational Research on Autoimmune and Allergic Disease-CAAD University of Piemonte OrientaleNovaraItaly Department of Translational Medicine Neurology UnitInterdisciplinary Research Center of Autoimmune Diseases(IRCAD)University of Piemonte OrientaleNovaraItaly PhD Program in Clinical and Experimental Medicine and Medical Humanities University of InsubriaVareseItaly

Osteopontin is a broadly expressed pleiotropic protein,and is attracting increased attention because of its role in the pathophysiology of several inflammatory,degenerative,autoimmune,and oncologic *** fact,in the last decade,several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion,but also increasing their *** detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions(i.e.,multiple sclerosis,Parkinson’s,and Alzheimer’s diseases).Intriguingly,recent findings show that osteopontin is involved not only in promoting tissue damage(the Yin),but also in repair/regenerative mechanisms(the Yang),mostly triggered by the inflammatory *** two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule,which are exposed after thrombin or metalloproteases *** functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix *** review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system *** the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein.

关键词： Alzheimer’s disease cytokine immunity microglia multiple sclerosis neuroinflammation neuroprotection neurotoxicity Parkinson’s disease Spp1 stroke

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