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Whole genome re-sequencing of sweet cherry(Prunus avium L.)yields insights into genomic diversity of a fruit species

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Horticulture Research 2020年第1期7卷 1889-1902页

作者： Aliki Xanthopoulou maria Manioudaki Christos Bazakos Christos Kissoudis anna-maria Farsakoglou Evangelos Karagiannis Michail Michailidis Chrysanthi Polychroniadou Antonios Zambounis Konstantinos Kazantzis Athanasios Tsaftaris Panagiotis Madesis Filippos Aravanopoulos Athanassios Molassiotis Ioannis Ganopoulos Laboratory of Pomology Department of AgricultureAristotle University of Thessaloniki54124 ThessalonikiGreece Institute of Plant Breeding and Genetic Resources ELGO-DEMETER.ThermiThessaloniki 570001Greece Perrotis College American Farm SchoolThessaloniki GR-57001Greece Laboratory of Forest Genetics&Tree Breeding Faculty of AgricultureForestry&Environmental ScienceAristotle University of ThessalonikiThessalonikiGreece Institute of Plant Breeding and Genetic Resources ELGO-DEMETER.Department of Deciduous Fruit GrowingNaoussa 59035Greece Institute of Applied Biosciences CERTHThermiThessaloniki 57001Greece

Sweet cherries,Prunus avium L.(Rosaceae),are gaining importance due to their perenniallity and nutritional attributes beneficial for human ***,sweet cherry cultivars exhibit a wide range of phenotypic diversity in important agronomic traits,such as flowering time and defense reactions against *** this study,wholegenome resequencing(WGRS)was employed to characterize genetic variation,population structure and allelic variants in a panel of 20 sweet cherry and one wild cherry genotypes,embodying the majority of cultivated Greek germplasm and a representative of a local wild cherry elite *** 21 genotypes were sequenced in an average depth of coverage of 33.91×.and effective mapping depth,to the genomic reference sequence of‘Satonishiki’cultivar,between 22.21×to 36.62×.Discriminant analysis of principal components(DAPC)with SNPs revealed two clusters of *** was a rapid linkage disequilibrium decay,as the majority of SNP pairs with r2 in near complete disequilibrium(>0.8)were found at physical distances less than 10 *** analysis of the variants showed that the genomic ratio of non-synonymous/synonymous(dN/dS)changes was *** higher dN frequency in the Greek cohort of sweet cherry could be the result of artificial selection pressure imposed by breeding,in combination with the vegetative propagation of domesticated cultivars through *** majority of SNPs with high impact(e.g.,stop codon gaining,frameshift),were identified in genes involved in flowering time,dormancy and defense reactions against pathogens,providing promising resources for future breeding *** study has established the foundation for further large scale characterization of sweet cherry germplasm,enabling breeders to incorporate diverse germplasm and allelic variants to fine tune flowering and maturity time and disease resistance in sweet cherry cultivars.

关键词： breeding sweet insight

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Sulfur metabolism and its manipulation in crops

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Journal of Genetics and Genomics 2016年第11期43卷 623-629页

作者： anna Koprivova Stanislav Kopriva Botanical Institute and Cluster of Excellence on Plant Sciences(CEPLAS) University of Cologne

Sulfur is an essential nutrient for all organisms. It is present in amino acids cysteine and methionine, many co-enzymes and prosthetic groups, sulfolipids, sulfated peptides, and diverse secondary metabolites. Sulfur is taken up by plants as the inorganic oxidized anion sulfate, which is assimilated into the variety of cellular metabolites.

关键词： Sulfur metabolism and its manipulation in crops

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Dorsal and ventral streams across sensory modalities

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Neuroscience Bulletin 2012年第3期28卷 291-300页

作者： anna Sedda Federica Scarpina Department of Humanistic Studies- Psychology Section University of Pavia

In this review, we describe the current models of dorsal and ventral streams in vision, audition and touch. Available theories take their first steps from the model of Milner and Goodale, which was developed to explain how human actions can be efficiently carried out using visual information. Since then, similar concepts have also been applied to other sensory modalities. We propose that advances in the knowledge of brain functioning can be achieved through models explaining action and perception patterns independently from sensory modalities.

关键词： sensorimotor integration action control perception dorsal stream ventral stream cross-modal

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Acyclic colorings of graphs with bounded degree

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Science China Mathematics 2016年第7期59卷 1427-1440页

作者： FIEDOROWICZ anna SIDOROWICZ Elzbieta Faculty of Mathematics Computer Science and Econometrics University of Zielona Góra

A k coloring(not necessarily proper) of vertices of a graph is called acyclic, if for every pair of distinct colors i and j the subgraph induced by the edges whose endpoints have colors i and j is acyclic. We consider some generalized acyclic k colorings, namely, we require that each color class induces an acyclic or bounded degree graph. Mainly we focus on graphs with maximum degree 5. We prove that any such graph has an acyclic 5 coloring such that each color class induces an acyclic graph with maximum degree at most 4. We prove that the problem of deciding whether a graph G has an acyclic 2 coloring in which each color class induces a graph with maximum degree at most 3 is NP complete, even for graphs with maximum degree 5. We also give a linear time algorithm for an acyclic t improper coloring of any graph with maximum degree d assuming that the number of colors is large enough.

关键词： acyclic coloring bounded degree graph computational complexity

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Gut Microbiota and Cytokine Profile in Cirrhosis

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 689-700页

作者： Irina Efremova Roman Maslennikov anna Kudryavtseva Anastasia Avdeeva George Krasnov Mikhail Diatroptov Vyacheslav Bakhitov Salekh Aliev Natalia Sedova maria Fedorova Elena Poluektova Oxana Zolnikova Nariman Aliev anna Levshina Vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscowRussia Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia V.A.Nasonova Research Institute of Rheumatology MoscowRussia Consultative and Diagnostic Center 2 of the Moscow Health Department MoscowRussia First Hospital Surgery Department Pirogov Russian National Research Medical UniversityMoscowRussia Department of Clinical Laboratory Diagnostics FGBOU DPO“Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation”MoscowRussia The Interregional Public Organization“Scientific Community for the Promotion of the Clinical Study” MoscowRussia

Background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in *** study aimed to evaluate the correlations between ***:In the blood plasma of cirrhosis patients and controls,27 cytokines were examined using a multiplex *** plasma levels of nitrites(stable metabolites of the endothelial dysfunction biomarker nitric oxide)and lipopolysaccharide(LPS)were *** fecal microbiota was assessed by 16S rRNA gene ***:Levels of IL-1b,IL-2,IL-6,IL-13,IP-10,IFN-g,TNF-a,LPS,and nitrites were higher in cirrhosis patients than in controls,while levels of IL-4,IL-7,and PDGF-BB were *** LPS level was directly correlated with the levels of IL-1b,IL1-Ra,IL-9,IL-17,PDGF-BB,IL-6,TNF-a,and *** nitrite level was significantly directly correlated with the levels of TNF-a,GM-CSF,IL-17,and IL-12,and inversely correlated with the IL-7 ***-a levels were directly correlated with ascites severity and the abundance of Negativicutes,Enterobacteriaceae,Veillonellaceae,and Klebsiella,while inversely correlated with the abundance of Firmicutes,Clostridia,and ***-g levels were directly correlated with the abundance of Bacteroidaceae,Lactobacillaceae,Bacteroides,and Megasphaera,and inversely correlated with the abundance of Verrucomicrobiota,Akkermansiaceae,Coriobacteriaceae,Akkermansia,Collinsella,and ***-1b levels were directly correlated with the abundance of Comamonadaceae and Enterobacteriaceae and inversely correlated with the abundance of Marinifilaceae and ***-6 levels were directly correlated with the abundance of Enterobacteriaceae,hepatic encephalopathy,and ascites severity,and inversely correlated with the abundance of Peptostreptococcaceae,Streptococcaceae,and ***:The abundance of harmful gut microbiota taxa and endotoxinemia directly correlates with the levels of proinflammatory cytokines.

关键词： Endotoxin Leaky gut Gut microbiome Systemic inflammation Gut-liver axis Endotoxemia

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Underground Space 2021年第1期6卷 35-45页

作者： Estanislao Pujades anna Jurado Department of Computational Hydrosystems UFZ–Helmholtz Centre for Environmental ResearchPermoserstr.1504318 LeipzigGermany Institute for Groundwater Management Technische Universitat DresdenDresdenGermany

The expected growth of urban areas requires the construction of underground infrastructures,especially for improving transportation and *** new infrastructures are commonly constructed below the water table because they must be deeper than previous underground *** addition,many urban areas are located near surface water bodies(i.e.,seas,rivers and/or lakes)that induce a shallow water ***"cut and cover"method combined with dewatering wells is a frequently used procedure under these conditions for the construction of underground *** main concerns of this procedure are related to the stability of the excavation bottom,the behavior of the retaining walls and/or the impacts induced by the dewatering *** issues must be evaluated,and new solutions must be proposed to improve its weak *** paper compiles the main publications focused on the construction of underground infrastructures below the water table and in urban areas by using the cut and cover method combined with *** review reveals that,despite many published studies,more research is needed to address some relevant issues such as:(1)the mitigation of dewatering impacts by using artificial recharge,(2)the adaptation of methods for characterizing retaining walls to be used under heterogeneous conditions,(3)the improvement of the prediction of surface settlements produced by pumping,and(4)the consideration of non-Darcy flows in the design of dewatering systems.

关键词： Dewatering Excavation Cut and cover Retaining walls Settlements

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LEBESGUE DECOMPOSITION AND BARTLE-DUNFORD-SCHWARTZ THEOREM IN PSEUDO-D-LATTICES

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Acta Mathematica Scientia 2013年第3期33卷 653-677页

作者： anna AVALLONE Paolo VITOLO Dipartimento di Matematica e Informatica Università della BasilicataViale dell'Ateneo Lucano 10 85100 Potenza Italy

Let L be a pseudo-D-lattice. We prove that the exhaustive lattice uniformities on L which makes the operations of L uniformly continuous form a Boolean algebra isomorphic to the centre of a suitable complete pseudo-D-lattice associated to L. As a consequence, we obtain decomposition theorems such as Lebesgue and Hewitt-Yosida decompositions--and control theorems such as Bartle-Dunford Schwartz and Rybakov theorems--for modular measures on L.

关键词： Pseudo-effect algebra pseudo-D-lattice D-uniformity lattice uniformity mod-ular measure

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Protein-losing pseudomembranous colitis with cap polyposis-like features

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World Journal of Gastroenterology 2017年第16期23卷 3003-3010页

作者： Wolfgang Kreisel Guenther Ruf Richard Salm Adhara Lazaro Bertram Bengsch anna-maria Globig Paul Fisch Silke Lassmann Annette Schmitt-Graeff Department of Medicine II GastroenterologyHepatologyEndocrinology and Infectious DiseasesMedical CenterUniversity of FreiburgFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany Department of General and Visceral Surgery Center for SurgeryUniversity of FreiburgFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany Department of Surgery RKK Bruder-Klaus-Krankenhaus79183 WaldkirchGermany Institute for Exercise and Occupational Medicine Center for MedicineMedical Center-University of FreiburgFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany Silke Lassmann Annette Schmitt-GraeffInstitute of Surgical PathologyMedical Center and Faculty of MedicineUniversity of Freiburg79106 FreiburgGermany

Protein-losing enteropathy(PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Here we present an unusual case of severe PLE in a 55-year old female with a one-year history of recurrent diarrhea, crampy abdominal pain, and peripheral edema. Endoscopy and MRI showed a diffuse inflammatory thickening of the sigmoid colon and the rectum. Surgical resection of the involved colon was performed and the symptoms were significantly resolved. The final histologic evaluation confirmed a diagnosis of a pseudomembranous colitis with cap polyposis-like features. Such a cause of PLE has never been described before.

关键词： Protein-losing enteropathy Cap polyposis Ulcerative colitis Goblet cells Pseudomembranes

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New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease

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World Journal of Gastroenterology 2015年第3期21卷 982-987页

作者： Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel anna maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj Ⅱ.Medizinische Klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany Hals-Nasen Ohren Klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany

AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI ***:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-*** real-time RT-PCR for each of the H+K+-ATPase subunits was *** p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII ***:Twenty patients with LPR symptoms were *** only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical *** another patient,real-time RT-PCR for each H+K+-ATPase subunit was *** out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/*** patients had pathological results in both functional *** out of twenty patients responded to ***:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR *** hypotheses for the pathomechanism are *** role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting.

关键词： Laryngopharyngeal reflux Proton pump inhibitor Gas

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On complete convergence in Marcinkiewicz-Zygmund type SLLN for random variables

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Applied Mathematics(A Journal of Chinese Universities) 2021年第3期36卷 342-353页

作者： anna Kuczmaszewska YAN Ji-gao Department of Applied Mathematics Lublin University of TechnologyNadbystrzycka 38 D20-618 LublinPoland School of Mathematical Sciences Soochow UniversitySuzhou 215006China

We consider a generalization of Baum-Katz theorem for random variables satisfying some cover ***,we get the results for many dependent structures,such as END,ϱ^(*)mixing,ϱ^(-)mixing andφ-mixing,etc.

关键词： complete convergence Marcinkiewicz-Zygmund type SLLN weakly mean bounded

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