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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： Andreia monteiro Susana monteiro Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia monteiro António J.Salgado Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Effects of laying on of hands with and without a spiritual context on pain and functionality of older women with knee osteoarthritis:study protocol for a randomized controlled trial

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Journal of Integrative Medicine 2018年第2期16卷 106-112页

作者： Katy Andrade monteiro Zacaron Nélia da silva Mendes Yuri Cotta e silva Giancarlo Lucchetti School of Medicine Federal University of Juiz de ForaJuiz de Fora 36036-330Brazil Institute of Life Sciences Department of PhysiotherapyFederal University of Juiz de ForaGovernador Valadares 35012-140Brazil Faculty of Physical Therapy Federal University of Juiz de ForaJuiz de Fora 36036-330Brazil

Background： Laying on of hands （LooH） is a culturally-accepted therapy in several traditions. In Brazil, ＂Spiritism＂（third-largest religious tradition in number of followers） uses LooH with the name of ＂Spiritist Passe＂（SP）. However, there are few studies assessing SP＇s role in medical outcomes. The present study aims to investigate the effects of LooH, with and without a spiritual context, on pain, joint stiffness, and functional capacity of older women （≥60 years old） with knee osteoarthritis （KOA）. Methods/design： In this triple-blind, prospective randomized controlled trial, older women with KOA are assigned to three groups： LooH with a spiritual context group, LooH group without a spiritual context, and a control group receiving no intervention. Patients are assessed by a blinded researcher at baseline, 8 weeks, and 16 weeks. Pain, joint stiffness, and functional capacity are assessed using Western Ontario and McMaster Universities Osteoarthritis Index. Other measures such as anxiety, depression, gait speed, and quality of life will also be assessed. To detect differences between groups, a post-intervention com- parison between the three groups and a mean change （post-pre） comparison among the three groups will be done using analysis of variance. All statistical analyses will be performed using an intention-to-treat approach and a per-protocol analysis. Discussion： A pragmatic design using SP, LooH without spiritual context, and no LooH may provide further scientific evidence on SP＇s feasibility and efficacy for KOA patients.

关键词： Complementary therapies Spiritual therapies Therapeutic touch Spiritual healing Holistic therapies Knee osteoarthritis

Perianal disease in inflammatory bowel disease:Broadening treatment and surveillance strategies for anal cancer

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World Journal of Gastroenterology 2024年第28期30卷 3373-3385页

作者： Tatiana Pacheco Sara monteiro Luísa Barros Jorge silva Department of Gastroenterology Centro Hospitalar do Tamega e SousaPenafiel 4560-136Portugal

The perianal disease affects up to one-third of individuals with Crohn's disease(CD),causing disabling symptoms and significant impairment in quality of life,particularly for those with perianal fistulising CD(PFCD).The collaborative effort between gastroenterologists and surgeons is essential for addressing PFCD to achieve fistula closure and promote luminal *** fistula healing rates with conventional therapies have prompted the emergence of new biological agents,endoscopic procedures and surgical techniques that show promising *** these,mesenchymal stem cells injection is a particularly hopeful *** addition to the burden of fistulas,individuals with perianal CD may face an increased risk of developing anal *** underscores the importance of surveillance programmes and timely interventions to prevent late diagnoses and poor ***,there is no established formal anal screening *** this review,we provide an overview of the current state of the art in managing PFCD,including novel medical,endoscopic and surgical *** discussion also focuses on the relevance of establishing an anal cancer screening programme in CD,intending to propose a risk-based surveillance *** validation of this surveillance programme would be a significant step forward in improving patient care and outcomes.

关键词： Inflammatory bowel disease Crohn's disease Perianal Fistula Anus diseases Management Anal cancer Screening

Modeling of Fluidized Bed Gasification:Assessment of Zero-dimensional and CFD Approaches

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Journal of Thermal Science 2015年第4期24卷 378-385页

作者： Nuno Couto Valter silva Eliseu monteiro P.S.D.Brito Abel Rouboa University of Tras-os-Montes and Alto Douro INEGI/Faculty of Engineering University of Porto C3i-Interdisciplinary Center for Research and Innovation Polytechnic Institute of PortalegreLugar da AbadessaApartado 1487301-901PortalegrePortugal MEAM Department University of Pennsylvania

In modeling fluidized bed gasification experiments,equilibrium and CFD models are valuable *** existence of multi-dimensional effects inside the reactor vessel due to the kinetics of the process and the fluid dynamics phenomena could result in deviation from the zero-dimensional *** models integrating kinetics and hydrodynamics are being developed by using a computer fluid dynamics(CFD)*** objective of this investigation is to assess and compare the adequacy of zero-dimensional and CFD approaches in modeling fluidized bed gasification regarding a semi-industrial scale(numerical results are validated under experimental runs).Results show that the zero-dimensional model based on the approach of dual stage equilibrium performs reasonably well in adequately predicting the product gas composition at different operating conditions and for different feedstocks,although with quantitative ***,the discrepancy depends on the oxygen content of the oxidation agent and on the steam-to biomass ratio decreasing when these parameters *** models provide deeper information being able to estimate the syngas composition or other operating parameter at any point of space and *** of some quantitative discrepancy,the zero-dimensional modeling approach is deemed satisfactory from the viewpoint of the determining design conditions simulation.

关键词： Gasification CFD model Dual stage equilibrium model

Immunomodulation as a neuroprotective strategy after spinal cord injury

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Neural Regeneration Research 2018年第3期13卷 423-424页

作者： Susana monteiro António J. Salgado Nuno A. silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBragaPortugal ICVS/3B's-PT Government Associate Laboratory Braga/GuimaraesPortugal

The initial trauma to the spinal cord is just the starting point for a cascade of endogenous events that will collectively determine the injury extension. These secondary events include, but are not limited to： glutamate excitoxicity, induction of apoptotic pathways, ionic imbalances and the development of a strong and dysfunctional inflammatory response. The secondary injury is associated to an aggravation of neuronal damage increasing the extent of neurological deficits （Ek et al., 2010）.

关键词： Immunomodulation as a neuroprotective strategy after spinal cord injury SCI

Industry return lead‑lag relationships between the US and other major countries

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Financial Innovation 2023年第1期9卷 1055-1102页

作者： Ana monteiro Nuno silva Helder Sebastiao CeBER Faculty of EconomicsUniv CoimbraAv Dias da Silva 1653004‑512 CoimbraPortugal

In this study,we analyze the lead-lag relationships between the US industry index and those of six other major countries from January 1973 to May *** identify the leading role played by the US internationally by showing that the weekly returns of US industries,especially the US basic materials and energy industries,significantly Granger cause the returns of most other countries’industries,suggesting that non-US industries react with some delay to new *** delayed reaction is even more notice-able during periods of recession in the US when cross-country correlations are *** implies that the ability of the lagged returns of US industries to predict industries’returns from other countries is even more pronounced when the US experienced an economic recession.A similar asymmetric relationship is found between the volatil-ity of US industries and that of industries in other *** analysis of causality in the distribution of returns and volatility shows that causality runs mainly from the US to other countries,particularly in the presence of extreme negative ***,we demonstrate that our predictions are valuable to real-world ***-short strategies generate sizable and statistically significant alphas,and a constant relative risk-averse investor obtains certainty equivalent returns well above the risk-free rate.

关键词： International diversification Industry equity indexes Granger causality Causality in distribution

Multi-mechanical waves against Alzheimer’s disease pathology:a systematic review

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Translational Neurodegeneration 2021年第3期10卷 459-486页

作者： Francisca monteiro Ioannis Sotiropoulos Óscar Carvalho Nuno Sousa Filipe S.silva Center for Microelectromechanical Systems(CMEMS) University of MinhoCampus Azurém4800-058 GuimarãesPortugal Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoCampus Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Biosciences&Applications NCSR“Demokritos” AthensGreece

Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people *** inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this *** vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented *** of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory ***,there is a huge variety of treatment specifcations,and in many cases,conficting results are *** this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 *** studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older *** the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated ***,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.

关键词： Alzheimer’s disease Auditory stimulation Mechanical vibrations Ultrasounds Whole-body vibration

Seismic performance of composite moment-resisting frames achieved with sustainable CFST members

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 312-332页

作者： A. silva Y. JIANG L. MACEDO J. M. CASTRO R. monteiro N. SILVESTRE Department of Civil Engineering Faculty of Engineering University of Porto Porto 4099-002 Portugal Istituto Universitario di Studi Superiori di Pavia Pavia 27100 Italy IDMEC LAETA Department of Mechanical Engineering Instituto Superior Tecnico Universidade de Lisboa Lisboa 1649-004 Portugal

The main objective of the research presented in this paper is to study the bending behaviour of Concrete Filled Steel Tube （CFST） columns made with Rubberized Concrete （RuC）, and to assess the seismic performance of moment-resisting frames with these structural members. The paper describes an experimental campaign where a total of 36 specimens were tested, resorting to a novel testing setup, aimed at reducing both the preparation time and cost of the test specimens. Different geometrical and material parameters were considered, namely cross-section type, cross-section slenderness, aggregate replacement ratio, axial load level and lateral loading type. The members were tested under both monotonic and cyclic lateral loading, with different levels of applied axial loading. The test results show that the bending behaviour of CFST elements is highly dependent on the steel tube properties and that the type of infill does not have a significant influence on the flexural behaviour of the member. It is also found that Eurocode 4 is conservative in predicting the flexural capacity of the tested specimens. Additionally, it was found that the seismic design of composite moment- resisting frames with CFST columns, according to Eurocode 8, not only leads to lighter design solutions but also to enhanced seismic performance in comparison to steel frames.

关键词： concrete filled steel tubes rubberized concrete composite frames seismic performance assessment