Immunomodulation as a neuroprotective strategy after spinal cord injury

作     者：Susana Monteiro António J. Salgado Nuno A. Silva 

作者机构：Life and Health Sciences Research Institute(ICVS)School of MedicineUniversity of MinhoCampus de GualtarBragaPortugal ICVS/3B's-PT Government Associate LaboratoryBraga/GuimaraesPortugal 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第3期

页      面：423-424页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by Prémios Santa Casa Neurociências-Prize Meloe Castro for Spinal Cord Injury Research Portuguese Foundation for Science and Technology(Financiado noambito do Projecto 3599-Promover a Producao Científica e Desenvolvimento Tecnológico e a Constituicao de Redes Temáticas(3599-PPCDT) project:PTDC/DTP-FTO/5109/2014 Post-Doctoral fellowship-SFRH/BPD/97701/2013-to N.A.Silva IF Development Grant to A.J.Salgado 

主　　题：Immunomodulation as a neuroprotective strategy after spinal cord injury SCI 

摘      要：The initial trauma to the spinal cord is just the starting point for a cascade of endogenous events that will collectively determine the injury extension. These secondary events include, but are not limited to： glutamate excitoxicity, induction of apoptotic pathways, ionic imbalances and the development of a strong and dysfunctional inflammatory response. The secondary injury is associated to an aggravation of neuronal damage increasing the extent of neurological deficits （Ek et al., 2010）.