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The protective effect of Murraya koenigii leaves against carbon tetra chloride-induced hepatic damage in rats

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Journal of Coastal Life Medicine 2014年第4期 313-318页

作者： Brahma Naidu Parimi Ramgopal Mopuri balaji Meriga Department of Biochemistry S.V.U College of SciencesSri Venkateswara UniversityTirupatiAndhra PradeshIndia

Objective:To evaluate the efficacy of methanolic extract of Murraya koenigii(MMK)leaves in attenuating the hepatic damage inflicted by carbon tetrachloride(CCl_(4)),a potent oxidative stress inducer and a model ***:Rats were divided into six groups of five each:normal control group,CCl_(4)group,CCl_(4+)silymarin group,CCl_(4+)MMK group(200 mg/kg body weight),CCl_(4+)MMK group(300 mg/kg body weight)and CCl_(4+)MMK group(500 mg/kg body weight).Rats were intraperitoneally injected with 20%CCl_(4),in corn oil(1 mL/kg body weight)and MMK was orally administered for 3 *** of hepatic markers such as alanine transaminase,aspartate transaminase,alkaline phosphatase and total billirubin were *** of superoxide dismutase,catalase and glutathione peroxidase were assayed and malondialdehyde content was *** histopathological examination,liver microtome sections were prepared and observed under light ***:Oral administration of MMK had significantly reduced the activities of aspartate transaminase,alanine transaminase,alkaline phosphatase and bilirubin content in a dosedependent manner,which were elevated by CCl_(4).However,CCl_(4)-induced rise in lipid peroxidation and drop in superoxide dismutase,catalase and glutathione peroxidase activities were reversed by MMK ***,the hepatoprotective activity of MMK was supported by histopathological examination of liver microtome ***:Our biochemical and histological studies demonstrate the potential antioxidant and hepatoprotective activity of MMK and our results scientifically validate the often use of MMK leaves in food preparation and in Ayurvedic medicine in India and neighboring countries.

关键词： Murraya koenigii Hepatoprotective Carbon tetrachloride Rats Silymarin

Astragalin and rutin restore gut microbiota dysbiosis， alleviate obesity and insulin resistance in high-fat diet-fed C57BL/6J mice

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Food Science and Human Wellness 2023年

作者： Muni Swamy Ganjayi Karunakaran Reddy Sankaran balaji Meriga Ruchika Bhatia Shikha Sharma Kanthi Kiran Kondepudi Department of Biochemistry， Sri Venkateswara University Food and Nutrition Biotechnology Division， National Agri-Food Biotechnology Institute

In the present study we investigated the impact of the Combination of Astragalin and Rutin (CAR) on restoring gut-microbial dysbiosis and obesity and obesity related disorders. Randomized male C57BL/6J mice were experimentally divided into five groups and fed either a normal diet or a high-fat diet (HFD) for 16 weeks. Compared to vehicle treated group (HFD group)， CAR could substantially improve selected gut microbiota abundance (Akkermansia， Lactobacillus， Bifidobacteria， muciniphila， Roseburia)， reversed the Firmicutes/Bacteroidetes proportions， and inhibited the growth of Escherichia coli， Salmonella， and Klebsiella in obese mice. In addition， CAR-treated mice showed significantly (P < 0.05) increased total short-chain fatty acid production， reduced body weight gain， organs’ weights， serum lipid profile (except HDL) and insulin resistance. The mRNA expressions of CCAAT/enhancer binding protein-α (C/EBP-α)， sterol regulatory element-binding protein-1c (SREBP-1c)， peroxisome proliferator-activated receptor-γ (PPAR‐γ)， acetyl-CoA carboxylase (ACC)， adipocyte protein 2 (aP2)， and fatty acid synthase (FAS) were downregulated (P < 0.05) and the protein expression of PPAR-γ was downregulated while AMPK was phosphorylated in CAR-treated HFD-fed mice compared to the HFD control group. Interestingly， CAR-treated HFD-fed mice showed significantly improved tissue architecture in the liver and fatty tissues. In conclusion， the findings suggest that CAR/Moringa oleifera may be beneficial in the treatment of insulin resistance and obesity disorders.

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Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation

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Cellular & Molecular Immunology 2015年第5期12卷 650-652页

作者： Mohan S Maddur Jamma Trinath Magalie Rabin Francis Bolgert Moneger Guy Jean-Michel Vallat Laurent Magy Kithiganahalli N balaji Srini V Kaveri Jagadeesh Bayry Institut National de la Sante et de la Recherche Medicale Paris France Centre de Recherche des Cordeliers Equipe - Immunopathology and Therapeutic Immunointervention Paris France Sorbonne Universites - UPMC Univ Paris 6 Paris France Universite Paris Descartes Paris France Department of Microbiology and Cell Biology Indian Institute of Science Bangalore India Centre de Reference 'Neuropathies Peripheriques Rares' et Service de Neurologie Hopital Universitaire Limoges Limoges France Reanimation Neurologique Neurologie 1 Hopital de la Pitie-Salpetriere Paris France International Associated Laboratory IMPACT (Institut National de la Sante et de la Recherche Medicale France -Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India

CD4＋FoxP3＋ regulatory T cells （Tregs） are immunosuppressive cells that are critical for immune tolerance. Several studies have demonstrated that one of the anti-inflammatory mechanisms of action of intravenous immunoglobulin （Wig） involves the expansion of Tregs. Recently, we demonstrated that IVIgmediated Treg expansion involves the cyclooxygenase-2 （COX-2）-dependent induction of prostaglandin E2 （PGE2） in human dendritic cells （DCs）. However, the validity of these findings in autoimmune patients is lacking.

关键词： associated increased prostaglandin

Field Interactive Robotic Entity （FIRE） Adaptive Learning of Environment Using Neural Networks A VLSI Implementation

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Field Interactive Robotic Entity （FIRE） Adaptive Learning ...

Self-assembled V2O5 interconnected microspheres produced in a fish-water electrolyte medium as a high- performance lithium-ion-battery cathode

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作者： Krishna Chandramouli balaji Sankarshanan SRM Institute of Science and Technology Kattankulathur Chennai India. SRM Institute of Science and Technology Kattankulathur Chennai India.

Field Interactive Robotic Entity (FIRE) is an ATMEL ? micro controller controlled (belong to the 8051 microcontroller) (3,4) robot. The maneuvering capabilities of the robot are based on two sen

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Nano Research 2015年第11期8卷 3591-3603页

作者： Md Mokhlesur Rahman Abu Z. Sadek Irin Sultana Mateti Srikanth Xiujuan J. Dai Matthew R. Field Dougal G. McCulloch Sri balaji Ponraj Ying Chen Institute for Frontier Materials Deakin University Waurn Ponds VIC 3216 Australia Melbourne Centre for Nanofabrication 151 Wellington Rd Clayton VIC 3168 Australia School of Applied Sciences Applied Physics RMIT University Melbourne VIC 3001 Australia

Interconnected microspheres of V2Os composed of ultra-long nanobelts are synthesized in an environmental friendly way by adopting a conventional anodization process combined with annealing. The synthesis process is simple and low-cost because it does not require any additional chemicals or reagents. Commercial fish-water is used as an electrolyte medium to anodize vanadium foil for the first time. Electron microscopy investigation reveals that each belt consists of numerous nanofibers with free space between them. Therefore, this novel nanostructure demonstrates many outstanding features during electrochemical operation. This structure prevents self-aggregation of active materials and fully utilizes the advantage of active materials by maintaining a large effective contact area between active materials, conductive additives, and electrolyte, which is a key challenge for most nanomaterials. The electrodes exhibit promising electrochemical performance with a stable discharge capacity of 227 mAh·g^-1 at 1C after 200 cycles. The rate capability of the electrode is outstanding, and the obtained capacity is as high as 278 at 0.5C, 259 at 1C, 240 at 2C, 206 at 5C, and 166 mAh·g^-1 at 10C. Overall this novel structure could be one of the most favorable nanostructures of vanadium oxide-based cathodes for Li-ion batteries.

关键词： self-assembly interconnected microspheres fish-water electrolyte V2O5 cathode lithium-ion batteries

Chemopreventive effect of apple and berry fruits against colon cancer

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World Journal of Gastroenterology 2014年第45期20卷 17029-17036页

作者： Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto Dyah Ekashanti Octorina Dewi Aqilah Leela T Narayanan Arunpandian balaji Aruna Priyadarshini Subramanian Mustafa Yusof IJN-UTM Cardiovascular Engineering Centre Faculty of Bioscience and Medical Engineering Universiti Teknologi Malaysia Department of Research and Development PSNA College of Engineering and Technology Department of Pharmacology

Colon cancer arises due to the conversion of precancerous polyps(benign)found in the inner lining of the *** is better than cure,and this is very true with respect to colon *** epidemiologic studies have linked colorectal cancer with food *** and berry juices are widely consumed among various ethnicities because of their nutritious *** this review article,chemopreventive effects of these fruit juices against colon cancer are *** dealing with bioavailability,in vitro and in vivo effects of apple and berry juices are emphasized in this article.A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell *** review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells,and also strives to facilitate clinical studies using these juices in humans in large *** conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer.

关键词： Apple Berry Chemoprevention Colon cancer Fruit juices Phytochemicals

Characterization of filoviral glycoproteins in viral entry

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Characterization of filoviral glycoproteins in viral entry

<i>Tephrosia purpurea</i>Fraction Attenuates Lipid Accumulation and Adipogenesis in 3T3-L1 Adipocytes and Reduces Body Weight in High Fat Diet Induced Obese Rats

2006年第二届新生病毒性疾病控制学术研讨会

作者：荣礼军 balaji Manicassamy Department of Microbiology and Immunology College of Medicine University of Illinois at Chicago ChicagoIL 60612USA

Filoviruses are enveloped, negative-sense, single stranded, RNA viruses with a genome of approximately 19kb. Filovirus family consists of Ebola virus (EBOV) and Marburg virus (MARV) which can cause severe hemorrhagic fever in humans and non-human primates with mortality rates up to 90%. Viral outbreaks are rare and endemic in central regions of the Africa subcontin. EBOV and MARV infections are predicted to occur in distinct ecological niches. EBOV infections usually occur in humid rain forests of central and western Africa and MARV infections occur in the drier regions of central and eastern Africa. The mode of transmission of filoviruses is not known, although fruit bats have been recently implicated as the natural reservoirs of Ebola virus. Several promising vaccination methods have been developed in non-human primate models, but currently there is no vaccine or treatment available for filovirus infection in human.

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Advances in Bioscience and Biotechnology 2019年第9期10卷 288-304页

作者： Karunakaran Reddy Sankaran Lokanatha Oruganti Krishna Chintakuntla balaji Meriga Department of Biochemistry Sri Venkateswara University Tirupati India

The anti-adipogenic and anti-obesity activity of chloroform fraction of Tephrosia purpurea (CFTp) on 3T3-L1 adipocytes and high fat diet (HFD)-fed obese rats was evaluated in this study. A substantial and dose dependent inhibition of α-glucosidase (81%) and lipase (75%) activities by CFTp was noticed. Treatment with CFTp (250 μg/mL) significantly inhibited 3T3-L1 adipocytes differentiation and lipid accumulation. A semi-quantitative RT-PCR analysis of 3T3-L1 cells revealed down regulation of mRNA expression of peroxisome proliferator-activated receptor-γ (PPAR-γ), fatty acid synthase (FAS) and acetyl CoA carboxylase-2 (ACC-2), while glucose transporter type-4 (GLUT-4) expression was up-regulated in a dose dependent manner with CFTp. Further, oral administration of CFTp (200 mg/***.) significantly reduced body weight gain, fat mass, blood glucose and leptin levels in high fat diet (HFD)-induced obese rats. Taken together, these findings demonstrate that CFTp possesses potent anti-obesity activities.

关键词： Body Weight Cell Viability Enzyme Inhibition Lipolysis 3T3-L1 Cells

Proteomic Alterations in Human Dermal Fibroblasts under Photo-Induced Pollution Caused by Excessive Solar Irradiations such as Infra-Red, Blue Light, UVA and UVB

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第1期13卷 16-32页

作者： Balu Muthaiyah Suresh Kumar Ramadoss Yellapantula Sree Gouri balaji Bandyopadhyay ITC Life Sciences and Technology Center (ITC LSTC) Bangalore India

Background: The skin serves as the first line of defense for the human body. Direct sunlight contains damaging radiations that can speed up the ageing process of the skin, resulting in wrinkles, leathery skin, dark patches, and solar elastosis. Objectives: To evaluate the effect of multiple solar irradiation related factors at the protein level in human dermal fibroblast (HDF). The overall effect of individual solar irradiations such as Infrared A (IRA), blue light (BL), UVA, and UVB on HDF cells and the extent of molecular level aberrations to be assessed and compared against each. Methods: Label-free quantitative proteomics (MS/MS) approach has been adopted in this study to observe the protein level changes induced in the HDF cells through various exposures of full light sources. Following that, downstream insilico analysis has been carried out. Results: In this study, it is demonstrated all the four different solar irradiations significantly contribute to the molecular degeneration of skin cells through various mechanisms. This study confirms that BL down-regulates DNA repair proteins and the skin cells-HDF stimulate the histone proteins as a response mechanism to maintain the chromosomal integrity. Conclusions: The proteomics experiment carried out in the current study intends to support the future sun care products based on full light protection technology that can be custom designed to provide complete protection from the solar radiation. Similar technology could enhance the further investigations for deeper understanding of induction, mode of action, and prevention of skin damage from extensive solar irradiation.

关键词： Full Light Technology Solar Irradiation Cellular Damage DNA Repair & Damage HDF Cells