Characterization of filoviral glycoproteins in viral entry
作者单位：Department of Microbiology and Immunology College of MedicineUniversity of Illinois at Chicago ChicagoIL 60612USA
会议名称：《2006年第二届新生病毒性疾病控制学术研讨会》
会议日期：2006年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：Filoviruses are enveloped, negative-sense, single stranded, RNA viruses with a genome of approximately 19kb. Filovirus family consists of Ebola virus (EBOV) and Marburg virus (MARV) which can cause severe hemorrhagic fever in humans and non-human primates with mortality rates up to 90%. Viral outbreaks are rare and endemic in central regions of the Africa subcontin. EBOV and MARV infections are predicted to occur in distinct ecological niches. EBOV infections usually occur in humid rain forests of central and western Africa and MARV infections occur in the drier regions of central and eastern Africa. The mode of transmission of filoviruses is not known, although fruit bats have been recently implicated as the natural reservoirs of Ebola virus. Several promising vaccination methods have been developed in non-human primate models, but currently there is no vaccine or treatment available for filovirus infection in human.