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隔离环境下通过胚胎移植获得无菌状态的小鼠

中国比较医学杂志 2006年第7期16卷 423-423页

作者： Inzunza.Josē Midtvedt.Tore Fartoo.Mona Norin.Elisabeth sterlund.Ewa Persson.anna-Karin hrlund-Richter.Lars

The technique of embryo transfer has been evaluated for the purpose of changing the mouse stocks to a germfree(GF)*** results showreproducible and quality-assured conversion of animalstothose which are negativeforthe presence of *** and easy access to GF mice is advantageous for studies of selected microflora andtheir cross-talks withthe host,when applying,***,proteomic and metabolic *** studyinvolved embryotransfer in anisolator environment,thereby allowingimplantationof cleansed embryosinto GFrecipients under well-controlled *** recipientfemales gave birth normally andtookcare of the offspringasif they were their own pups,thus enhancing the survival *** to full technical resources required to maintain GFisolators are,however,a *** this study,we used stainless steel isolators designed by Gustafsson(1959),on which a stereomicroscope wasmountedtofacilitate embryo transfer inside the *** use of embryo transfer and isolator techniques will facilitate the availability ofvarious mouse mutant models under different gnotobiotic conditions,GF,monoxenic or polyxenic animals,to enable comparison withconventional animals for physiological and pathophysiological studies.

关键词： MICE GERMFREE EMBRYOTRANSFER ISOLATOR

溶酶体酸化可增强吞噬性星形胶质细胞的消化功能

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神经损伤与功能重建 2015年第5期10卷 425-425页

作者： Kelly R.Monk M.Laura Feltri Carla Taveggia Camilla Lv Claire H.Mitchell Martin Simonsson anna Erlandsson 唐颖馨 Department of Neuroscience Uppsala University Uppsala University Hospital Department of Anatomy and Cell Biology University of Pennsylvania Department of Physiology University of Pennsylvania SciL ife Lab and Department of Computer Science Electrical & Space Engineering Lulea University of Technology Department of Public Health and Caring Sciences Uppsala University Rudbeck Laboratory

低效的溶酶体降解是多种脑部疾病发展的中心环节,但其具体机制及参与的细胞种类仍不清楚。既往研究显示,星形胶质细胞大量吞噬死亡的细胞,但将这些吞噬的物质储存在细胞内而不是进行降解。本研究对星形胶质细胞降解消化功能减弱的原因... 详细信息

低效的溶酶体降解是多种脑部疾病发展的中心环节,但其具体机制及参与的细胞种类仍不清楚。既往研究显示,星形胶质细胞大量吞噬死亡的细胞,但将这些吞噬的物质储存在细胞内而不是进行降解。本研究对星形胶质细胞降解消化功能减弱的原因进行研究,并探索增强星形胶质细胞降解消化功能的方法。结果显示,长期存在于吞噬泡周围的肌动环阻碍了溶酶体的吞噬溶解作用。此外,Rab27a蛋白可以通过Nox2减少溶酶体的酸化,而星形胶质细胞高表达Rab27a蛋白,阻碍抗原呈递。本研究还发现,Nox2与星形胶质细胞摄取的物质共定位,且表达主要组织相容性复合体II,提示这可能影响星形胶质细胞内的抗原呈递。使用酸化纳米粒子对星形胶质细胞溶酶体进行长时间的酸化处理,能增加星形胶质细胞对所摄取物质和死亡细胞的消化。但随着酸化时间的延长,星形胶质细胞的消化能力再次回复到较低水平,提示随着酸化作用的增强,细胞的对抗酸化的通路也相应增强了。

关键词： Nox2 消化星形胶质细胞溶酶体纳米粒子 pHrodo 染料吞噬作用

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定时淋浴头

环球科学 2010年第11期 12-12页

作者：安娜·库奇门特（anna Kuchment）郭凯声（译）申宁馨（校）

过去，格雷格·福茨（GregFoutz）每天早晨都要浪费大把时间和水．他说：“淋浴的时候，就是思维最活跃、头脑最灵光的时候。”麻烦的是，他淋浴的时间太长，以致上班迟到成了家常便饭[他的工作是在美国加利福尼亚州斯托克顿镇（Stockto... 详细信息

过去，格雷格·福茨（GregFoutz）每天早晨都要浪费大把时间和水．他说：“淋浴的时候，就是思维最活跃、头脑最灵光的时候。”麻烦的是，他淋浴的时间太长，以致上班迟到成了家常便饭[他的工作是在美国加利福尼亚州斯托克顿镇（Stockton）一家小店做比萨饼]。有一天，现年45岁的福茨突然灵机一动，

关键词：加利福尼亚州斯托克顿比萨饼时间

英国的女性和男性从哪里获取避孕用品?第三次全国性态度和生活方式调查结果(Natsal-3)

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英国医学杂志中文版 2019年第11期22卷 683-683页

作者： Rebecca S French Rebecca Geary Kyle Jones anna Glasier Catherine H Mercer Jessica Datta Wendy Macdowall Melissa Palmer Anne M Johnson Kaye Wellings 高辉(译) 不详首都医科大学附属北京天坛医院妇产科

背景评估英国使用不同来源避孕用品的使用率及其主要人口和行为特征的变化。方法采用横断面概率抽样法,在2010-2012年期间,对居住在英国的16~74岁的女性和男性进行访谈。共有4571名女性和3142名男性,年龄16~44岁,在过去一年间有阴道性... 详细信息

背景评估英国使用不同来源避孕用品的使用率及其主要人口和行为特征的变化。方法采用横断面概率抽样法,在2010-2012年期间,对居住在英国的16~74岁的女性和男性进行访谈。共有4571名女性和3142名男性,年龄16~44岁,在过去一年间有阴道性生活者接受访谈,排除已绝育(包括子宫切除术)者。避孕用品的来源分为:全科诊所、社区诊所、零售和其他。对这些来源的使用率及相关因素进行评估。

关键词：社区诊所子宫切除术避孕用品行为特征全科诊所性生活使用率横断面

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成人胃重复畸形超声表现1例

临床超声医学杂志 2021年第4期23卷 F0003-F0003页

作者：赖晓敏袁安娜方桂婷钟兴暨南大学附属第一医院超声科广州市510630

患者女,52岁,因体检发现腹腔肿物12 d入院。既往有支气管炎并扩张病史,否认消化系统疾病史、外伤史和手术史。体格检查无异常。超声检查:左上腹腔紧邻胃大弯侧胃壁见一大小约3.3 cm×2.7 cm类圆形等回声肿块,内部回声均匀,边缘见高回声... 详细信息

患者女,52岁,因体检发现腹腔肿物12 d入院。既往有支气管炎并扩张病史,否认消化系统疾病史、外伤史和手术史。体格检查无异常。超声检查:左上腹腔紧邻胃大弯侧胃壁见一大小约3.3 cm×2.7 cm类圆形等回声肿块,内部回声均匀,边缘见高回声环,环状部分区域呈现高-低-高回声,呈“双环征”,边界清晰,与脾脏、左肝分界清,CDFI于肿块内未探及明显血流信号(图1,2)。饮水后肿块与胃大弯侧胃壁关系密切。超声提示:左上腹胃大弯侧胃壁占位病变。腹部CT检查:胃底黏膜下见一大小约3.8 cm×2.9 cm×2.4 cm类圆形稍低密度影,边缘清晰,CT值28 HU,增强后病变见环形强化(图3,4),中央区未见明显强化,考虑胃间质瘤可能性大。胃镜检查:胃底大弯侧见一明显隆起,直径约3.5 cm,表面稍充血、红肿,其黏膜未见溃疡;胃镜诊断:胃底巨大隆起(图5)。术中见:胃底见一大小约4.0 cm×3.0 cm×4.0 cm肿物,未突破浆膜。术后病理检查提示:胃重复畸形(图6)。

关键词：胃大弯侧占位病变边缘清晰胃镜诊断胃间质瘤胃底消化系统疾病上腹腔

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超声诊断小腿坏死性筋膜炎1例

临床超声医学杂志 2019年第9期21卷 680-680页

作者：方桂婷陈伟健袁安娜钟兴暨南大学附属第一医院超声科

患者男,57岁,因反复双下肢水肿3年,加重10 d入院。既往有糖尿病、慢性肾衰竭、肝硬化、高血压病、痛风病史。体格检查:体温37.2℃,心率82次/min,呼吸频率14次/min,收缩压134 mm Hg(1 mm Hg=0.133 kPa),舒张压83 mm Hg,意识清楚,双下肢... 详细信息

患者男,57岁,因反复双下肢水肿3年,加重10 d入院。既往有糖尿病、慢性肾衰竭、肝硬化、高血压病、痛风病史。体格检查:体温37.2℃,心率82次/min,呼吸频率14次/min,收缩压134 mm Hg(1 mm Hg=0.133 kPa),舒张压83 mm Hg,意识清楚,双下肢重度凹陷性水肿,左侧较右侧明显,左侧膝关节红肿,伴皮温升高,有轻微压痛,无波动感。实验室检查:白细胞12.29×10^-9/L,肌酐228μmol/L,葡萄糖16.1 mmol/L,C反应蛋白68.73 mg/L。患者入院后行血液透析治疗5 d后双下肢水肿减轻,但左侧膝关节及小腿持续肿痛,行左侧膝关节X线检查未见明显异常。超声检查:左侧小腿后外侧皮下脂肪层增厚肿胀,内见条状无回声,皮下脂肪层与肌层间见片状低回声区,部分低回声区内探及大量气体强回声伴声影,加压后气体强回声可见游走,病变区域与邻近肌肉分界较清,深层肌肉未见明显受累(图1);CDFI:低回声区内探及丰富血流信号(图2)。

关键词：皮下脂肪层低回声区凹陷性水肿意识清楚深层肌肉波动感声影超声检查

Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves

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寻梦中国——来华留学生见闻录

孔子学院 2022年第6期 70-73页

作者： [亚美尼亚]安娜·亚当扬李睿(翻译) 郑晓羽(翻译) [泰国]温婵娥 [亚美尼亚]王小云王青青(翻译) [老挝]张婉 [亚美尼亚]梅兰周锐(翻译) 不详

南京是中国东南部的大城市之一,虽然没有上海和北京那么大,但比我的家乡埃里温(亚美尼亚共和国首都)大。南京是一座美丽的历史名城,是中国的千年古城、六朝古都,也是当今世界公认的绿色城市之一。提起南京,不得不说的就是道路两旁那参... 详细信息

南京是中国东南部的大城市之一,虽然没有上海和北京那么大,但比我的家乡埃里温(亚美尼亚共和国首都)大。南京是一座美丽的历史名城,是中国的千年古城、六朝古都,也是当今世界公认的绿色城市之一。提起南京,不得不说的就是道路两旁那参天的梧桐树。行走在这些梧桐树之间,古都千年风韵一览无余。

关键词：历史名城六朝古都来华留学生大城市见闻录南京

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid