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Digital Communications and Networks 2017年第3期3卷 164-175页

作者： Krishan kumar Arun Prakash Rajeev tripathi Department oJ:Electronics and Communication Engineering Motilal Nehru National Institute of Technology Allahabad 211004 India Electronics and Communication Engineering Department National Institute of Technology Hamirpur 177005 India Director Motilal Nehru National Institute of Technology Allahabad 211004 India

It is envisaged that in future Cognitive Radio （CR） networks deployment, multiple radio access networks may coexist. The networks may have different characteristics in terms of multiple attributes. CRs will have choices of selecting the optimal network out of the available networks. Optimal network selection is a challenging task that can be performed by spectrum handoff with Multiple Attribute Decision Making （MADM）. The spectrum handoff decision with MADM provides wider and optimal choice with quality of service. This motivates the development of a spectrum handoff scheme with MADM methods such as simple additive weighting, a technique for order preference by similarity to the ideal solution, a grey relational analysis and a cost function based method, which is the objective of this study. The CR preferences are based on voice, video and data services, called triple play services. The numerical results show that all MADM methods are effective for selecting the optimal network for spectrum handoff with a reduced complexity for the spectrum handoff decision. The paper shows that the proposed spectrum handoff scheme can be effectively implemented to select the optimal network according to triple play services in CR networks.

关键词： Spectrum handoff Cognitive radio SAW TOPSIS GRA Cost function

Near real-time characterisation of urban environments: a holistic approach for monitoring dengue fever risk areas

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International Journal of Digital Earth 2014年第11期7卷 916-934页

作者： Muhammad Shahzad Sarfraz Nitin kumar tripathi Asanobu Kitamoto Department of Computer Science COMSATS Institute of Information Technology(CIIT)AbbottabadPakistan Remote Sensing and GIS Asian Institute of Technology(AIT)BangkokThailand Digital Content and Media Sciences Research Division National Institute of Informatics(NII)TokyoJapan

Despite frequent use of digital devices in everyday life,cost-effective measurement of public health issues in urban areas is still *** study was,therefore,planned to extract land-use types using object-based and spatial metric approaches to explore the dengue incidence in relation to the surrounding environment in near real-time using Google and Advanced Land Observation Satellite *** characterised image showed useful classification of an urban areawith 77%accuracy and 0.68 *** analysis on public health data indicated that most of the dengue cases were found in densely populated areas surrounded by dense *** living in independent houses having sparsely vegetated surroundings were found to be less *** incidence was more prevalent in people of 5-24 years of age(67%);while in terms of occupation,mostly students,the unemployed,labourers and farmers(88%)were *** general,males were affected slightly more(10%)than *** analyses indicated that most of the dengue cases were around institutions(40%),religious places(18%)and markets(15%).Thus,usage of Digital Earth scalable tools for monitoring health issues would open new ways for maintaining a healthy and sustainable society in the years ahead.

关键词： dengue fever land-use land-cover monitoring dengue risk urban environment object-based classification

Antioxidant and antiarthritic potential of berberine: In vitro and in vivo studies

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Chinese Herbal Medicines 2023年第4期15卷 549-555页

作者： Shweta Jain Shalini tripathi Pushpendra kumar tripathi Sir Madanlal Institute of Pharmacy Etawah 206130India Rameshwaram Institute of Technology and Management Dr.A.P.J.Abdul Kalam Technical UniversityLucknow 226001India Institute of Pharmaceutical Sciences University of LucknowLucknow 226001India

Objective: To extract and isolate berberine from Berberis aristata(Berberidaceae). Isolated berberine was characterised using spectroscopy and its antioxidant and antiarthritic activity was ***: The berberine was isolated from B. aristata using microwave-assisted extraction(MAE) and characterised by a spectroscopic technique. The isolated berberine was evaluated for its antioxidant activity in DPPH, nitric oxide, and superoxide scavenging assays, while antiarthritic activity was evaluated in the complete freund’s adjuvant(CFA)-induced arthritis rat ***: The antioxidant activity of berberine revealed potent antioxidant activity in DPPH, nitric oxide,and superoxide scavenging assays. The in vivo antiarthritic activity of berberine in the CFA-induced arthritis rat model showed a significant reduction in paw diameter, arthritic score, and an increase in body weight. Furthermore, a concentration-dependent ameliorating action of berberine on haematological parameters was noticed. Proinfammatory biomarkers, including IL-6, IL-10, and TGF-b in serum were reported, and histopathology examination revealed that berberine decreased pannus formation, synovial hyperplasia, and bone erosion. Radiographic investigation showed soft tissue infammation, bone resorption and erosion, joint gap reduction, and substantial connective tissue expansion after treatment with ***: The ameliorating action on haematological parameters and proinfammatory biomarkers of berberine makes them a suitable remedy for the treatment of arthritis.

关键词： antioxidant antiarthritic activity berberine Berberis aristata DC microwave assistance

Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate

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Journal of Pharmaceutical Analysis 2019年第3期9卷 170-177页

作者： Arun kumar Awasthi Lalit kumar Punit tripathi Madhava Golla Cirandur Suresh Reddy Pramod kumar Micro Labs Ltd. Chemical Research Department API R&D Centre Plot No. 43-45 KIADB IVth Phase Bommasandra-Jigani Link Road Anekal Taluk Bangalore 560105 Karnataka India Department of Chemistry Sri Venkateswara University Tirupati 517502 Andhra Pradesh India

Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.;impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingredient (API). The identification and synthesis of all impurities except impurity E are well described in the literature;however, there is no report related to impurity E. The prospects to the formation and controlling of impurity E up to -0.03% in the synthesis of pantoprazole sodium sesquihydrate (PAN) were discussed in detail for the first time. The present work described the journey towards the successful development of an optimal preparation procedure of dimer impurity E. The most plausible mechanism involved in the formation of impurity E has been proposed.

关键词： Pantoprazole sodium sesquihydrate Impurity E Oxidation Enrichment Column chromatography Characterization HPLC

Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

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Biomedical and Environmental Sciences 2023年第11期36卷 1045-1058页

作者： Ruchi tripathi Sanjay kumar Banerjee Jay Prakash Nirala Rajani Mathur Department of Pharmacology Delhi Institute of Pharmaceutical Sciences & ResearchDelhi Pharmaceutical Sciences and Research University(DPSR-U))New DelhiINDIA Drug Discovery Research Centre Translational Health Science and Technology InstituteFaridabadINDIA Department of Biotechnology National Institute of Pharmaceutical Education and ResearchGuwahatiINDIA School of Environmental Sciences Jawaharlal Nehru UniversityNew DelhiINDIA

Objective In this study,the combined effect of two stressors,namely,electromagnetic fields(EMFs)from mobile phones and fructose consumption,on hypothalamic and hepatic master metabolic regulators of the AMPK/SIRT1-UCP2/FOXO1 pathway were elucidated to delineate the underlying molecular mechanisms of insulin *** Weaned Wistar rats(28 days old)were divided into 4 groups:Normal,Exposure Only(ExpO),Fructose Only(FruO),and Exposure and Fructose(EF).Each group was provided standard laboratory chow ad libitum for 8 ***,the control groups,namely,the Normal and FruO groups,had unrestricted access to drinking water and fructose solution(15%),***,the respective treatment groups,namely,the ExpO and EF groups,received EMF exposure(1,760 MHz,2 h/day x 8 weeks).In early adulthood,mitochondrial function,insulin receptor signaling,and oxidative stress signals in hypothalamic and hepatic tissues were assessed using western blotting and biochemical *** In the hypothalamic tissue of EF,SIRT1,FOXO 1,p-PI3K,p-AKT,ComplexⅢ,UCP2,MnSOD,and catalase expressions and OXPHOS and GSH activities were significantly decreased(P<0.05)compared to the Normal,ExpO,and FruO *** hepatic tissue of EF,the p-AMPKα,SIRT1,FOXO1,IRS1,p-PI3K,ComplexⅠ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,UCP2,and MnSOD expressions and the activity of OXPHOS,SOD,catalase,and GSH were significantly reduced compared to the Normal group(P<0.05).Conclusion The findings suggest that the combination of EMF exposure and fructose consumption during childhood and adolescence in Wistar rats disrupts the closely interlinked and multi-regulated crosstalk of insulin receptor signals,mitochondrial OXPHOS,and the antioxidant defense system in the hypothalamus and liver.

关键词： EMF-mobile phone Fructose Childhood-adolescence Insulin receptor signal Mitochondrial OxPHOS Antioxidant system Hypothalamic insulin resistance Hepatic insulin resistance

Emergence of the stromal vascular fraction and secretome in regenerative medicine

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World Journal of Stem Cells 2024年第10期16卷 896-899页

作者： Ratan kumar Choudhary Shanti Choudhary Abhishek tripathi College of Animal Biotechnology Guru Angad Dev Veterinary and Animal Sciences UniversityLudhiana 141004PunjabIndia Hilltop Animal Hospital PalatineIL 60074United States

Recently,we read a mini-review published by Jeyaraman et *** article explored the optimal methods for isolating mesenchymal stromal cells from adipose tissue-derived stromal vascular fraction(SVF).Key factors include tissue source,processing techniques,cell viability assessment,and the advantages/disadvantages of autologous vs allogeneic *** authors emphasized the need for standardized protocols for SVF isolation,ethical and regulatory standards for cell-based therapy,and safety to advance mesenchymal stromal cell-based therapies in human *** manuscript shares our perspective on SVF isolation in *** discussed future directions to potentiate effective regenerative medicine therapeutics in human and veterinary medicine.

关键词： Stromal vascular fraction Mesenchymal stem cells Veterinary regenerative medicine Isolation procedures,Canine model Secretome

Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients

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World Journal of Diabetes 2017年第3期8卷 112-119页

作者： Neerja Aggarwal Pawan kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata Madhu Basu Dev Banerjee anil Yadav Alpana Raizada Ashok kumar tripathi Department of Medicine University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital Department of Biochemistry University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital Pt. B. D. Sharma University of Health Sciences

AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) *** In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms.

关键词： Diabetic nephropathy Angiotensin converting enzyme inhibitor therapy Renin-angiotensin-aldosterone system gene polymorphisms Responder Urinary albumin/creatinine ratio Albuminuria

Linear and nonlinear optical changes in amorphous As2Se3 thin film upon UV exposure

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Progress in Natural Science:Materials International 2011年第3期21卷 205-210页

作者： Rashmi CHAUHAN Amit kumar SRIVASTAVA Arvind tripathi Krishna Kant SRIVASTAVA Department of Physic DAV CollegeCSJM UniversityKanpur208001India Department of Physics DBS CollegeCSJM UniversityKanpur208006India Materials Science Programme 4. Research Foundation for Education and Technology 5. Department of Physics DBS CollegeCSJM University

Amorphous As2Se3chalcogenide thin film was exposed to UV light(i line and g line) using mercury lamp for 30 min. XRD,UV/VIS spectroscopy and thickness measurements were taken for unexposed and exposed thin film for structural and optical *** optical constants(linear refractive index,extinction coefficient and linear optical absorption coefficient) of the film were calculated from transmission spectra using Swanepoel *** bandgap was determined using Tauc’s relation of indirect bandgap *** of the material was described by single-oscillator Wemple-DeDiDomenico model. Nonlinear optical constants(χ~((3)) and n2) were determined from linear optical parameters using semi-empirical relations in long wavelength *** changes in linear optical parameters(increase in refractive index,and extinction coefficient;reduction in optical bandgap),nonlinear optical parameter(increase inχ~((3))) are proposed for various photonic applications.

关键词： amorphous chalcogenide thin films UV exposure optical properties swanepoel method Wemple-DeDiDomenico model semi-empirical relations

DTM Simulation of Peristaltic Viscoelastic Biofluid Flow in Asymmetric Porous Media： A Digestive Transport Model

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Journal of Bionic Engineering 2015年第4期12卷 643-655页

作者： Dharmendra tripathi Osman Anwar Beg Praveen kumar Gupta Ganjam Radhakrishnamacharya Jagannath Mazumdar Department of Mechanical Engineering Manipal University Jaipur Jaipur 303007 India Gort Engovation-Bio-Propulsion Research Gabriel's Wing House Bradford BD6 1FA UK Department of Mathematics National Institute of Technology Silchar Silchar 788010 India Department of Mathematics National Institute of Technology Warangal 506004 India School of Electrical & Electronic Engineering The University of Adelaide Adelaide SA 5005 Australia

A biofluid dynamics mathematical model is developed to study peristaltic flow of non-Newtonian physiological liquid in a two-dimensional asymmetric channel containing porous media as a simulation of obstructed digestive （intestinal） transport. The fractional Oldroyd-B viscoelastic rheological model is utilized. The biophysical flow regime is constructed as a wave-like motion and porous medium is simulated with a modified Darcy-Brinkman model. This model is aimed at describing the diges- tive transport in intestinal tract containing deposits which induce impedance. A low Reynolds number approximation is em- ployed to eliminate inertial effects and the wavelength to diameter ratio is assumed to be large. The differential transform method （DTM）, a semi-computational technique is employed to obtain approximate analytical solutions to the boundary value problem. The influences of fractional （rheological material） parameters, relaxation time, retardation time, amplitude of the wave, and permeability parameter on peristaltic flow characteristics such as volumetric flow rate, pressure difference and wall friction force are computed. The present model is relevant to flow in diseased intestines.

关键词： peristaltic transport fractional Oldroyd-B model porous medium differential transform method asymmetricchannel obstructed digestive flow

Oxygen isotope-salinity relation in an Arctic fjord(Kongsfjorden):Implications to hydrographic variability

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Geoscience Frontiers 2018年第6期9卷 1937-1943页

作者： Manish Tiwari Siddhesh Nagoji Vikash kumar Shubham tripathi Padmasini Behera National Centre for Polar&Ocean Research Vasco-da-GamaGoa 403804India

The global warming leads to a large freshwater influx into the Arctic Ocean, which has adverse implications to the sea-ice dynamics, ocean circulation, and acidification. The relationship between oxygen isotope ratio(δ^(18)O) and salinity(S) is helpful in exploring various hydrographic processes related to the freshwater influx and is also required to accurately determine past salinity variability using oxygen isotope ratio of the carbonates. In view of this, systematic measurements of δ^(18)O and salinity of water from an Arctic fjord(Kongsfjorden) were carried out during the summer season of 2013. Until now, the relationships between δ^(18)O and salinity from such fjords were based on a limited number of samples collected during a very short span of time and thus may not accurately represent the long-term conditions prevailing in the fjord. The present study determines a more representative δ^(18)O-salinity relationship as water samples from different depths and location over a long period were systematically collected. The water samples were collected from four different locations at different depths along the axis of the fjord representing the inner and outer fjords. The inner stations(1-8 and 1-6) exhibit lowerδ^(18)O values than the outer stations(1-1 and 1-3), which indicate the higher influence of freshwater from glacial melting in the inner stations. The δ^(18)O-salinity relationship from the inner and outer fjords yield a slope of 0.54(r^2 = 0.67, n = 56) and 0.39(r^2 = 0.66, n = 68), respectively. The δ^(18)O of freshwater influx in the fjord is estimated at-18.4‰, which is close to the widely accepted freshwater-δ^(18)O value of the Arctic basin. The δ^(18)O of glacial discharge, which is the largest source of freshwater influx to the fjord, is estimated at ca.-21.0‰, which will be useful for future freshwater budget calculations.

关键词： Arctic Fjord Oxygen isotopes Salinity Freshwater Melting