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1.3 μm emitting SrF2：Nd^3＋ nanoparticles for high contrast in vivo imaging in the second biological window

Nano Research 2015年第2期8卷 649-665页

作者： Irene Villa Anna Vedda Irene Xochilt Cantarelli Marco Pedroni Fabio Piccinelli Marco Bettinelli Adolfo Speghini Marta Quintanilla Fiorenzo Vetrone Ueslen Rocha Carlos Jacinto Elisa Carrasco Francisco Sanz Rodrfguez angeles juarranz Blanca del Rosal Dirk H. Ortgies Patricia Haro Gonzalez Jose Garcia Sole Daniel Jaque Garcia Department of Materials Science University of Milano-Bicocca Via R. Cozzi 55 20125 Milano Italy Dipartimento di Biotecnologie Universita di Verona and INSTM UdR Verona Strada le Grazie 15 37134 Verona Italy Institut National de la Recherche Scientifique-Energie Materiaux et Telecommunications Universitd du Quebec Varennes QC PQ J3X 1S2 Canada Grupo de Fotonica e Fluidos Complexos Instituto de Fisica Universidade Federal de Alagoas 57072-970 Maceio Alagoas Brazil Departamento de Biologia Facultad de Ciencias Campus de Cantoblanco Universidad Autdnoma de Madrid Madrid 28049 Spain Fluorescence Imaging Group Departamento de Fisica de Maferiales Facultad de Ciencias Campus de Cantoblanco Universidad Aut6noma de Madrid Madrid 28049 Spain

Novel approaches for high contrast, deep tissue, in vivo fluorescence biomedical imaging are based on infrared-emitting nanoparticles working in the so-called second biological window （1,000-1,400 nm）. This allows for the acquisition of high resolution, deep tissue images due to the partial transparency of tissues in this particular spectral range. In addition, the optical excitation with low energy （infrared） photons also leads to a drastic reduction in the contribution of autofluorescence to the in vivo image. Nevertheless, as is demonstrated here, working solely in this biological window does not ensure a complete removal of autofluorescence as the specimens diet shows a remarkable infrared fluorescence that extends up to 1,100 nm. In this work, we show how the 1,340 nm emission band of Nd3. ions embedded in SrF2 nanoparticles can be used to produce autofluorescence free, high contrast in vivo fluorescence images. It is also dem- onstrated that the complete removal of the food-related infrared autofluorescence is imperative for the development of reliable biodistribution studies.

关键词： fluorescence imaging rare earth dopednanoparticles nanomedicine

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Explainable Artificial Intelligence(XAI)Model for Cancer Image Classification

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 401-441页

作者： Amit Singhal Krishna Kant Agrawal angeles Quezada Adrian Rodriguez Aguiñaga Samantha Jiménez Satya Prakash Yadav Department of Computer Science&Engineering Raj Kumar Goel Institute of TechnologyGhaziabad201017India Department of School of Computing Science and Engineering Galgotias UniversityGreater Noida203201India Tecnológico Nacional de México Campus Tijuana Baja California22414México Universidad Autónoma de Baja California TijuanaBaja California22414México Department of Computer Science and Engineering G.LBajaj Institute of Technology and Management(GLBITM)Affiliated to Dr.A.P.J.Abdul Kalam Technical UniversityLucknow201306India School of Computer Science Engineering and Technology(SCSET) Bennett UniversityGreater Noida201310India

The use of Explainable Artificial Intelligence(XAI)models becomes increasingly important for making decisions in smart healthcare *** is to make sure that decisions are based on trustworthy algorithms and that healthcare workers understand the decisions made by these *** models can potentially enhance interpretability and explainability in decision-making processes that rely on artificial ***,the intricate nature of the healthcare field necessitates the utilization of sophisticated models to classify cancer *** research presents an advanced investigation of XAI models to classify cancer *** describes the different levels of explainability and interpretability associated with XAI models and the challenges faced in deploying them in healthcare *** addition,this study proposes a novel framework for cancer image classification that incorporates XAI models with deep learning and advanced medical imaging *** proposed model integrates several techniques,including end-to-end explainable evaluation,rule-based explanation,and useradaptive *** proposed XAI reaches 97.72%accuracy,90.72%precision,93.72%recall,96.72%F1-score,9.55%FDR,9.66%FOR,and 91.18%*** will discuss the potential applications of the proposed XAI models in the smart healthcare *** will help ensure trust and accountability in AI-based decisions,which is essential for achieving a safe and reliable smart healthcare environment.

关键词： Explainable artificial intelligence artificial intelligence XAI healthcare cancer image classification

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Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of Clinical Oncology 2024年第2期15卷 195-207页

作者： angeles C Tecalco-Cruz Karen H Medina-Abreu Enrique Oropeza-Martínez Jesus Zepeda-Cervantes AleidaVázquez-Macías Marina Macías-Silva Posgrado en Ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Colegio de Ciencias y Humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología Celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

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Fundamentals of Robotic Mechanical Systems 3rd ed. 2007

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丛书名： Mechanical Engineering Series

2007年

作者： Jorge angeles

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New concepts for generating interspecies chimeras using human pluripotent stem cells

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Protein & Cell 2022年第4期13卷 234-238页

作者： Alejandro De Los angeles Jun Wu Department of Psychiatry Yale University School of MedicineNew HavenCTUSA Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA

The worldwide paucity of transplantable organs for patients is a devastating *** different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies *** blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of *** principle,interspecies blastocyst complementation may one day allow the generation of human organs inside ***,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).

关键词： organs donor generating

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ISG15 and ISGylation:Emergence in the cytoskeleton dynamic and tumor microenvironment

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BIOCELL 2022年第5期46卷 1209-1213页

作者： angeles C.TECALCO-CRUZ Posgrado en Ciencias Genómicas Universidad Autónoma de la Ciudad de México(UACM)Ciudad de México03300México

Cytoskeletal remodeling affects the shape,adhesion,and motility of *** dynamics are modulated by matrix proteins,integrins,and several cytokines in the tumor *** this scenario,signaling is activated by integrins and interferons,which can induce ISG15 gene *** gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation ***,non-conjugated ISG15 acts as a cytokine-like *** this viewpoint,the interplay between free ISG15,protein ISGylation,and cytoskeletal dynamics in the tumor microenvironment is discussed.

关键词： Tumor microenvironment ISG15 ISGylation Cytoskeleton dyn

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Environmental Occurrence of Selenium in Waters and Related Health Significance

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Biomedical and Environmental Sciences 1997年第2期10卷 292-299页

作者： JANE L. VALENTINE(School of Public Health, University of CalIfornia at Los angeles, Los angeles, CA 90024, USA) School of Public Health University of California at Los Angeles 90024 USA.

Appreciable amounts of selenium in spring and well waters can be found due to geological occurrence. Concentrations of as much as 400 9000 μg/l have been reported in U. S. *** levels are 8 to 180 times the current EPA drinking water standard and approximate dietary exposures of 4900μg in selenosis regions of China. Reviews of health significance of the elevated drinking water exposures to U. S. populations revealed elevated concentrations of selenium in urine and blood. A decrease in glutathione peroxidase activity in such instances was noted. However noticeable symptoms and signs seem absent in studies reviewed. A comparison of intake levels (diet or drinking water) to urinary excretion for residents of China and the U. S. produced a correlation coefficient, r = 0. 82 (P < 0. 01 ) for the three research studies available

关键词： In Am Environmental Occurrence of Selenium in Waters and Related Health Significance

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Posterior gut development in Drosophila:a model system for identifying genes controlling epithelial morphogenesis

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Cell Research 1998年第4期8卷 273-284页

作者： LENGYEL JUDITH A XUE JUN LIU (Department of Molecular, Cell and Developmental Biology University of California at Los angeles, Los angeles, CA USA, 90095-1606 USA) Department of Molecular Cell and Developmental Biology University of California at Los Angeles Los Angeles USA

The posterior gut of the Drosophila embryo, consisting of hindgut and Malpighian tubules, provides a simple,well-defined system where it is possible to use a genetic approach to define components essential for epithelial *** review here the advantages of Drosophila as a model genetic organism, the morphogenesis of the epithelial structures of the posterior gut, and what is known about the genetic requirements to form these *** overview, primordia are patterned by expression of hierarchies of transcription factors; this leads to localized expression of cell signaling molecules, and finally, to the least understood step: modulation of cell adhesion and cell shape. We describe approaches to identify additional genes that are required for morphogenesis of these simple epithelia, particularly those that might play a structural role by affecting cell adhesion and cell shape.

关键词： Organogenesis cell rearrangement convergent extension hindgut Malpighian tubule

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OPTIMAL COARSE GRID SIZE IN DOMAIN DECOMPOSITION

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Journal of Computational Mathematics 1994年第4期12卷 291-297页

作者： Tony Chan Jian-Ping Shao(Department of Mathematics, University of Califoruia, Los angeles, USA) University of California 美国

In most domain decomposition (DD) methods, a coarse grid solve is employed to provide the global coupling required to produce an optimal method. The total cost of a method can depend sensitively on the choice of the coaxse grid size H. In this paper, we give a simple analysis of this phenomenon for a model elliptic problem and a variant of Smith's vertex space domain decomposition method [11, 3]. We derive the optimal value Hopt which asymptotically minimises the total cost of method (number of floating point operations in the sequential case and execution time in the parallel case), for subdomain solvers with different complekities. Using the value of Hopt, we derive the overall complexity of the DD method, which can be significantly lower than that of the subdomain solver

关键词： UCLA OPTIMAL COARSE GRID SIZE IN DOMAIN DECOMPOSITION CAM

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On the Equivalence of Multiplicative Structures in Floer Homology and Quantum Homology

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Acta Mathematica Sinica,English Series 1999年第1期15卷 53-80页

作者： Gang LiuDepartment of Mathematics,UCLA,Los angeles,CA 90095 USAGang TianDepartment of Mathematics,MIT,Cambridge,MA 02139,USA Department of Mathematics UCLA Los Angeles USA Department of Mathematics MIT Cambridge USA

In this paper,we will prove that Floer homology equipped with either the intrinsic or exterior product is isomorphic to quantum homology as a *** will also prove that GW-invariants in Floer homology and quantum homolo... 详细信息

关键词： Floer homology Quantum homology GW-invariants J-holomorphic curves Moduli space

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