Posterior gut development in Drosophila:a model system for identifying genes controlling epithelial morphogenesis

作     者：LENGYEL JUDITH A XUE JUN LIU (Department of Molecular, Cell and Developmental Biology University of California at Los Angeles, Los Angeles, CA USA, 90095-1606 USA) 

作者机构：Department of Molecular Cell and Developmental Biology University of California at Los Angeles Los Angeles CA USA 90095-1606 USA 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：1998年第8卷第4期

页      面：273-284页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071002[理学-动物学] 

基　　金：Eunice Kennedy Shriver National Institute of Child Health and Human Development  NICHD  (R01HD009948) 

主　　题：Organogenesis cell rearrangement convergent extension hindgut Malpighian tubule 

摘      要：The posterior gut of the Drosophila embryo, consisting of hindgut and Malpighian tubules, provides a simple,well-defined system where it is possible to use a genetic approach to define components essential for epithelial *** review here the advantages of Drosophila as a model genetic organism, the morphogenesis of the epithelial structures of the posterior gut, and what is known about the genetic requirements to form these *** overview, primordia are patterned by expression of hierarchies of transcription factors; this leads to localized expression of cell signaling molecules, and finally, to the least understood step: modulation of cell adhesion and cell shape. We describe approaches to identify additional genes that are required for morphogenesis of these simple epithelia, particularly those that might play a structural role by affecting cell adhesion and cell shape.