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What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases

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World Journal of Gastroenterology 2015年第37期21卷 10563-10572页

作者： Débora Menezes da costa Eliane dos santos Pereira Silvia Helena Barem Rabenhorst Molecular Genetics Laboratory Department of Pathology and Forensic Medicine School of Medicine Federal University of Ceará

Helicobacter pylori(H. pylori) infection is present in more than half the world's population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric *** clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cag A and vac A genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cag A-negative. Several other virulence genes have been searched for, but these genes remain less well known that cag A and vac A. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and ice A based on the relevance shown in several studies in the literature.

关键词： Helicobacter pylori Virulence genes Cagpathogenici

Spatiotemporal Variability of Methane over the Amazon from Satellite Observations

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Advances in Atmospheric Sciences 2016年第7期33卷 852-864页

作者： Igor Oliveira RIBEIRO] Rodrigo Augusto Ferreira de SOUZA Rita Valeria ANDREOLI Mary Toshie KAYANO Patrfcia dos santos costa Post-Graduate Program in Climate and Environment CLIAMBINPA/UEAAv.Andre Araujo2936Campus 11Aleixo69060-001ManausAMBrasil Amazonas State University Superior School of TechnologyAv.Darcy Vargas1200Parque 10 de Novembro69065-020ManausAMBrasil National Institute for Space Research Center For Weather Forecasting and Climate ResearchAv.dos Astronautas175812227-010Sao Josd dos CamposSPBrasil

The spatiotemporal variability of the greenhouse gas methane （CH4） in the atmosphere over the Amazon is studied using data from the space-borne measurements of the Atmospheric Infrared Sounder on board NASA＇s AQUA satellite for the period 2003-12. The results show a pronounced variability of this gas over the Amazon Basin lowlands region, where wetland areas occur. CH4 has a well-defined seasonal behavior, with a progressive increase of its concentration during the dry season, followed by a decrease during the wet season. Concerning this variability, the present study indicates the important role of ENSO in modulating the variability of CH4 emissions over the northern Amazon, where this association seems to be mostly linked to changes in flooded areas in response to ENSO-related precipitation changes. In this region, a CH4 decrease （increase） is due to the E1 Nifio-related （La Nifia-related） dryness （wetness）. On the other hand, an increase （decrease） in the biomass burning over the southeastern Amazon during very dry （wet） years explains the increase （decrease） in CH4 emissions in this region. The present analysis identifies the two main areas of the Amazon, its northern and southeastern sectors, with remarkable interannual variations of CH4. This result might be useful for future monitoring of the variations in the concentration of CH4, the second-most important greenhouse gas, in this area.

关键词： climate variability methane satellite data Amazon region

Auriculotherapy in primary health care: A large-scale educational experience in Brazil

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Journal of Integrative Medicine 2019年第4期17卷 302-309页

作者： Charles Dalcanale Tesser Ari Ojeda Ocampo More Melissa costa santos Emiliana Domingues Cunha da Silva Fatima Terezinha Pelachini Farias Lucio Jose botelho Department of Public Health Federal University of Santa Catarina Floriandpolis Santa Catarina 88036-800 Brazil Post-graduate Program in Public Health Federal University of Santa Catarina Florianopolis Santa Catarina 88036-800 Brazil Integrative Medicine and Acupuncture Service University Hospital Federal University of Santa Catarina Floriandpolis Santa Catarina 88036-800 Brazil Floriandpolis Municipality Health Office Florianopolis Santa Catarina 88036-800 Brazil

Auriculotherapy consists of physical stimuli applied to the outer ear and is commonly associated with traditional Chinese medicine (TCM). The authors present and discuss the development of a course that offers a semi-on-site auriculotherapy course for Brazilian primary health care (PHC) professionals. The course was funded by the Brazilian Ministry of Health and developed at the Federal University of Santa Catarina in 2015 by a team of experts in auriculotherapy. It consisted of 75 h of distance learning (five sequential modules) and 5 h of on-site learning. The modules included the following items:(1) introduction to integrative practices;(2) ear reflexology;(3) introduction to TCM;(4) biomedical view of auriculotherapy;and (5) auriculotherapy in PHC. The teaching material in eluded a workbook for each module, 14 video lectures and an interactive ear(on line resource) to study location and application to the main auricular points. The on-site lectures follow a structured script of ear palpation techniques, auricular seed insertion practice and clinical case discussions, under the supervision of trained instructors. The course was offered in 2016 and 2017 and on-site lectures took place in 25 cities, covering all Brazilian regions, in coordination with municipal or state boards of health. A total of 4273 health professionals concluded the training and their evaluation of the course was highly positive. The Brazilian experience of large-scale training shows the potential to disseminate auriculotherapy in the context of PHC, given that its practice is fast, easy to learn, safe, effective for different health problems and well accepted by the patients.

关键词： Auriculotherapy Traditional Chinese medicine Primary health care Health education Distance learning

Electromagnetic Characterization of Recyclable Polymer Nanofibers Based on PSU/Carbonyl Iron

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Journal of Renewable Materials 2019年第3期7卷 279-287页

作者： Daniel Consoli Silveira Tiago Teixeira da Silva Braga Daniel Molina Gil Newton Adriano dos santos Gomes Lilia Müller Guerrini Edson Cocchieri botelho Department of Materials and Technology Sao Paulo State University(UNESP)School of EngineeringGuaratinguetá/SP-Brazil Electronic Warfare Laboratory Technological Institute of Aeronautics(ITA)Sao Josédos Campos/SP-Brazil Institute of Science and Technology Federal University of Sao Paulo(UNIFESP)Sao Josédos Campos/SP-Brazil

This study investigated and defined the optimal processing parameters for the electrospinning of polysulfone polymer solutions with N,*** of parameters such as solute concentration,electrical voltage,and working distance were correlated with the quality of the obtained nanofibers using morphological characterization via scanning electron microscopy(SEM).Carbonyl iron additive was dispersed in the polymer solutions,using ultrasonic tip,and the material processed via electrospinning with aforementioned parameters *** with the property of interaction with electromagnetic waves were *** dispersion of different concentrations of the additive and electromagnetic characterizations in the X-band of microwaves(8.2 and 12.4 GHz),using vector network analyzer(VNA)and rectangular waveguide,allowed the identification of the materials electromagnetic *** parameters allowed the calculation of reflected and transmitted energy by the material.

关键词： Carbonyl iron electromagnetic characterization electrospinning nanofibers polysulfone

Analysis of alternative parameters of dynamic resistance measurement in high voltage circuit breakers

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High Voltage 2019年第3期4卷 197-202页

作者： Herbet Filipe dos santos Sousa Adriano costa de Oliveira George Victor Rocha Xavier Henrique Nunes de Santana Edson Guedes da costa Tarso Vilela Ferreira Federal University of Campina Grande Campina GrandeBrazil Federal University of Sergipe AracajuBrazil

Throughout its lifetime,high-voltage circuit breaker(HVCB)contacts suffer from inevitable degradation processes,especially during the formation of electric *** degraded contacts can reduce the current interruption capacity and increase the chances of operational faults,which might lead to considerable financial ***,the use of efficient evaluating techniques is a key factor to achieve systems *** dynamic resistance measurement(DRM)is a technique that can be used to evaluate the degradation level of HVCB'*** stands out from the usual technique,static resistance measurement,by allowing the assessment of both the main contacts and the arcing contacts(ACs).Usually,the mean resistance or the area under the DRM curve is used to estimate the AC ***,DRM is a non-standardised technique and there are no specified parameters to evaluate the real wear ***,an analysis of alternative parameters extractible from the DRM technique is presented in this study,such as amplitude and variance of the DRM *** results attest the possible use of more than one parameter for the continuous evaluation of HVCB ACs,characterising the DRM as a more complete and precise diagnosis tool.

关键词： resistance parameters dynamic

Analysis of 12 variants in the development of gastric and colorectal cancers

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World Journal of Gastroenterology 2017年第48期23卷 8533-8543页

作者： Giovanna C Cavalcante Marcos AT Amador Andre M Ribeiro dos santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F costa Ney PC santos Paulo P Assumpcao Andrea Ribeiro dos santos Sidney santos Laboratório de Genética Humana e Médica Universidade Federal do Pará Núcleo de Pesquisas em Oncologia Universidade Federal do Pará

AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in CASP8,CYP2 E1,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 genes) were genotyped in a single PCR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PCR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS *** After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of GC. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of CRC. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. Carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing GC than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing CRC than carriers of other *** These findings are important for the comprehension of gastric and CRC development,particularly in highly admixed populations,such as the Brazilian population.

关键词： Inflammatory processes Immune response Genomic and cellular stability Gastric cancer Colorectal cancer Amazon

Raman Spectra of Nd:La3Ga5SiO14 and Nd:La3Ga5.5Ta0.5O14 Crystals

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Chinese Journal of Structural Chemistry 2016年第11期35卷 1673-1678页

作者：张娜娜王继扬潘晓茹宋明君 Clenilton costa dos santos Ilde Guedes da Guedesa College of Chemistry & Chemical and Environmental Engineering Weifang University State Key Laboratory of Crystal Materials Shandong University Departamento de Física CCETUniversidade Federal do Maranh?o Departamento de Física Universidade Federal do CearáCampus do Pici

Single crystals of Nd：La3Ga5SiO14 （NLGS） and Nd：La3Ga5.5Ta0.5O14 （NLGT） were grown by Czochralski method. Both crystals exhibit a langasite structure （space group D32 （P321） with Z = 1）, whose general formula is A3BC2D3O14, where A, B, C and D represent the dodecahedral, octahedral and tetrahedral positions, respectively. The adding of low content of Nd does not change the crystal structure. Although they are isostructural, the distribution of atoms among the symmetric sites is different. While NLGT exhibits a perfect orderly structure, NLGS exhibits an intrinsically disordered structure due to the random distribution of Ga and Si atoms at the C3（2） symmetry sites. To understand what changes occur in the phonon distribution when Ta replaces Si, we recorded and analyzed room temperature polarized Raman spectra. We observe 8A1＋18E modes for NLGS and 10A1＋13E for NLGT crystals. When Si is substituted by Ta, we observe that the wavenumber of some modes related to vibrations involving Ga and O atoms decreases. This agrees with the fact that the Ga–O bonds are shorter in NLGS than in NLGT.

关键词： Czochralski method langasite structure Raman scattering piezoelectric

Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?

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World Journal of Gastroenterology 2014年第18期20卷 5235-5243页

作者： Camila A Figueiredo Cintia Rodrigues Marques Ryan dos santos costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves Instituto de Ciências da Saúde Universidade Federal da BahiaSalvadorBahia 41110-100Brazil

Helicobacter pylori(***)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human *** is a risk factor for gastritis,ulcer disease and stomach *** against *** is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including ***,host genetic factors that affect cytokines may determine differences in the susceptibility to many *** this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to *** and discuss how such polymorphisms may influence infection/disease outcomes.

关键词： Helicobacter pylori Stomach cancer Immunity Cytokines Polymorphisms

Challenges in maintaining the probiotic potential in alcoholic beverage development

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Food Bioscience 2023年第2期52卷 133-142页

作者： Daiane costa dos santos Josemar Goncalves de Oliveira Filho Juliana Risso Andretta Fabiano Guimaraes Silva Mariana Buranelo Egea Goias Federal University(UFG) Institute of Tropical Pathology and Public HealthIPTSP-UFGStreet 235s/nEast University Sector74605-450GoianiaGOBrazil Sao Paulo State University(UNESP) Sacholo of Pharmaceutical SciencesRodovia Araraquara-Jau Km 114800-903AraraquaraSao PauloBrazil Goiano Federal Institute of Education Science and TechnologyCampus Rio VerdeRod.Sul GoianaKm 01Cx Postal 6675901-970Rio VerdeGOBrazil

The development of new functional alcoholic beverages to promote health benefits is a major challenge for current *** review presents the main applications of microorganisms with functional potential and resistant to the alcoholic environment as well as the characteristics that enable the use of alcoholic beverages as vehicles for probiotic *** our online search,it was possible to notice that the most prominent microorganisms with functional potential and that present alcohol resistance were Saccharomyces cerevisiae *** and water-kefir(composed of Saccharomyces sp.,Lactobacillus sp.,Leuconostoc sp.,Acetobacter sp.,Bifidobacterium sp.).Processing conditions,temperature,fermentation time,and raw materials used in the production of beverages are important parameters that are evaluated and are dependent on the alcohol concentration and cellular viability of the desired probiotic microorganism(s).Viability studies of probiotic microorganisms in vegetable matrices have been conducted for water-kefir and Saccharomyces *** was successfully incorporated into the developmental process of alcoholic beverages with alcohol contents ranging from 3.83 to 23%(v/v),whereas kefir beverage had an alcohol content ranging from 0.8 to 4.96%(v/v).Furthermore,to ensure the maintenance of probiotic viability in alcoholic matrices,the encapsulation technique can be used as an alternative to promote greater protection and viability of probiotics against adverse conditions.

关键词： Functional beverage Microbiological resistance Alcohol concentration