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Machine learning-guided accelerated discovery of structure-property correlations in lean magnesium alloys for biomedical applications

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Journal of Magnesium and Alloys 2024年第6期12卷 2267-2283页

作者： Sreenivas Raguraman Maitreyee Sharma Priyadarshini Tram Nguyen Ryan McGovern andrew kim Adam J.Griebel Paulette Clancy Timothy P.Weihs Department of Materials Science and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins Extreme Materials Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Translational Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Research and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnesium alloys are emerging as promising alternatives to traditional orthopedic implant materials thanks to their biodegradability,biocompatibility,and impressive mechanical ***,their rapid in-vivo degradation presents challenges,notably in upholding mechanical integrity over *** study investigates the impact of high-temperature thermal processing on the mechanical and degradation attributes of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cost-efficient characterization methods like X-ray diffraction and optical microscopy,we swiftly examine microstructural changes post-thermal *** Pearson correlation coefficient analysis,we unveil the relationship between microstructural properties and critical targets(properties):hardness and corrosion ***,leveraging the least absolute shrinkage and selection operator(LASSO),we pinpoint the dominant microstructural factors among closely correlated *** findings underscore the significant role of grain size refinement in strengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phase in corrosion *** suggests that achieving an optimal blend of strength and corrosion resistance is attainable through fine grains and reduced concentration of ternary *** thorough investigation furnishes valuable insights into the intricate interplay of processing,structure,and properties in magnesium alloys,thereby advancing the development of superior biodegradable implant materials.

关键词： Magnesium alloys Machine learning Corrosion Mechanical properties Rapid characterization

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FIRE SUPPRESSION PERFORMANCE OF WATER MIST SYSTEMS WITH ADDITIVES

FIRE SUPPRESSION PERFORMANCE OF WATER MIST SYSTEMS WITH ADDI...

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2000安全与科学技术国际会议

作者： andrew K.kim Fire Risk Management Program Institute for Research in Construction National Research Council of Canada Ottawa Canada KIA OR6

＜正＞ Recently, National Research Council of Canada （NRC）, initiated a study to determine the effectiveness offine water mist system in extinguishing open space fires using single fluid swirl-type nozzles. In the study, theeffectiveness of using small amounts of foam forming additives in the fine water mist was also investigated. Testswere conducted using wood crib fires, and heptane and diesel pool fires. This paper summarizes the results of theexperiments that compared the relative importance of different suppression mechanisms of the fine water mistsystem as well as the effectiveness of using additives in the water mist.

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Explosion Suppression of an Armoured Vehicle Crew Compartment

Explosion Suppression of an Armoured Vehicle Crew Compartmen...

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2004安全科学与技术国际会议

作者： andrew kim George Crampton Fire Research Program Institute for Research in Construction National Research Council of CanadaOttawa Ontario K1A 0R6 Canada Fire Research Program Institute for Research in Construction National Research Council of CanadaOttawa Ontario K1A 0R6 Canada

A project was initiated to identify and evaluate candidate options for the protection of the crew compartment of tanks and armoured personnel carriers from fire and explosion hazards. Three potential

关键词： explosion suppression armoured vehicle crew compartment

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水雾在扑灭大型工业燃油炊具油池火的应用(英文)

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消防科学与技术 2006年第2期25卷 223-232页

作者： DON CARPENTER andrew K. kim Fire Research Program Institute for Research in Construction National Research Council of Canada Ottawa Canada K1A 0R6

大型商用燃油炊具面积巨大,并涉及到大量热油,灭这种大型商用燃油炊具火灾非常困难。利用水雾系统对大型商用燃油炊具保护进行了研究,从理论和试验对水雾系统的灭火机理以及扑灭大型油池火灾需要达到的相关标准进行了研究。根据灭火机... 详细信息

大型商用燃油炊具面积巨大,并涉及到大量热油,灭这种大型商用燃油炊具火灾非常困难。利用水雾系统对大型商用燃油炊具保护进行了研究,从理论和试验对水雾系统的灭火机理以及扑灭大型油池火灾需要达到的相关标准进行了研究。根据灭火机理和相关标准,设计了两套水雾灭火系统,进行了一系列的实体火灾试验。研究表明,两套水雾灭火系统成功地扑灭了大型油池火灾,有效预防了复燃。其灭火性能取决于水雾系统类型、喷射压力以及炊具罩的位置。

关键词：水雾灭火燃油火灾商用燃油炊具

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韩国网络教育的介绍

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中国远程教育 2011年第22期 54-54页

作者： andrew kim 北京易迅方舟科技有限公司

韩国414所大学中，78％都提供了远程教育服务。韩国的远程教育正在致力于扩展互动教学，扩大电子教育的适用性和可用性，并尝试知识共享。同时，韩国正在计划向公众开放在线课堂，目前已经开始投入。

关键词：韩国网络教育远程教育服务互动教学电子教育知识共享可用性适用性

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Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

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Molecules “buckle up” to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第01期 3-4页

作者： Seokhyoung kim Department of Chemistry Michigan State University

Layered 2D metal halide perovskites (MHPs) are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic properties. These properties are readily tunable by controlling the halide composition, number of inorganic layers, and the chemistry of organic cations. Another key element that can substantially impact the materials’ functionalities is crystal morphology [1].

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Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

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鞘内注射小剂量吗啡用于儿童手术后镇痛的研究

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麻醉与镇痛 2008年第2期4卷 83-89页

作者： Arjunan Ganesh andrew kim Pasquale Casale Giovanni Cucchiaro 赵峰(译) 崔苏扬(校) Department of Anesthesia and Critical Care Medicine The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine Philadelphia Pennsylvania Department of Surgery Division of Urology The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine Philadelphia Pennsylvania Department of Anesthesiology White Plains Hospital White Plains New York 不详

背景本研究拟评估鞘内注射小剂量吗啡（4—5μg/kg）用于儿童不同手术后镇痛的有效性和安全性。方法检索疼痛管理数据和2003年10月至2006年3月期间费城儿童医院行鞘内注射小剂量吗啡手术后镇痛患儿的病历资料。所有患儿均在鞘内注射后随... 详细信息

背景本研究拟评估鞘内注射小剂量吗啡（4—5μg/kg）用于儿童不同手术后镇痛的有效性和安全性。方法检索疼痛管理数据和2003年10月至2006年3月期间费城儿童医院行鞘内注射小剂量吗啡手术后镇痛患儿的病历资料。所有患儿均在鞘内注射后随访24—48小时。结果共分析了187例患儿。平均年龄5．6±5．1岁（中位数4．0，四分值距1．0—10．0）。根据FLACC评分和语言数字评分，24小时内患儿最大疼痛评分中位数均为0，四分值距分别为0～3和0—4。首次使用阿片类补救镇痛的时间为22．4±16．9小时（范围：0—48小时，95％可信区间：19．9—24．8小时）。手术后24小时内，70例（37％）患儿无需阿片类药物镇痛（口服或静注）。117例应用阿片类药物的患儿中59例（50％）仅用羟考酮镇痛。33％使用酮咯酸镇痛的患儿单纯（11％）或联合（22％）使用了静脉或口服阿片类药镇痛。恶心、呕吐、瘙痒和尿潴留的发生分别为32％、37％和6％。1例患儿发生一过性硬脊膜穿刺后头痛，2例患儿手术后60分钟后因偶发低氧血症需要吸氧。未发生需辅助通气或纳洛酮治疗的呼吸抑制。结论鞘内注射小剂量吗啡对于儿童手术后镇痛是有效且安全的。

关键词：费城儿童医院手术后镇痛小剂量吗啡鞘内注射阿片类药物疼痛评分硬脊膜穿刺纳洛酮治疗

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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

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