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Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations

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Journal of Pharmaceutical Analysis 2018年第3期8卷 168-175页

作者： Sara da Silva Anacleto Marcella Matos Cordeiro Borges Hanna Leijoto de oliveira andressa Reis Vicente Eduardo Costa de Figueiredo Marcone Augusto Leal de oliveira Barbara Juliana Pinheiro Borges Marcelo Antonio de oliveira Warley de Souza Borges Keyller Bastos Borges departamento de Ciencias Naturals Universidade Federal de Sao Joao del-Rei Campus Dom Bosco Praca Dora Helvecio 74 Fabricas 36301-160 Sao Joao del-Rei Minas Gerais Brazil departamento de Quimica Universidade Federal do Espirito Santo Avenida Fernando Ferrari 514 Goiabeiras 29075-910 Vitdria Espirito Santo Brazil Laboratorio de Analise de Toxicantes e Farmacos Faculdade de Ciencias Farmaceuticas Universidade Federal de Alfenas Rua Gabriel Monteiro da Silva 700 Centro 37130-000 Alfenas Minas Gerais Brazil departamento de Quimica Universidade Federal de Juiz de Fora Rua Jose Lourenco Kelmer s/n 36036-330 Juiz de Fora Minas Gerais Brazil Centro de Ciencias da Saude Universidade Federal do Espirito Santo Avenida Marechal Campos 1468 Maruipe 29.043-900 Vitori Espirito Santo Brazil Centro Universitario Norte do Espirito Santo Universidade Federal do Espirito Santo Br 101 Norte Km 67 Sao Mateus Espirito Santo Brazil

This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy （FTIR）, thermogravimetry （TG）, and scanning electronic microscopy （SEM） can be useful tools for evaluating the quality of active pharmaceutical ingredients （APIs） and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simulta- neous determination of lidocaine （LID）, ciprofloxacin （CFX） and enrofloxacin （EFX） in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini Cm （250 mm×4.6 mm, 5μm） Phenomenex column, at a temperature of 25℃, with a mobile phase containing 10 mM of phosphoric acid （pH 3.29）： acetonitrile （85.7：14.3, v/v） and a flow rate of 1.5 mL/min. Physicochemical characterization by TG, FTIR, and SEM of raw materials of LID, CFX, and EFX provided information useful for the evaluation, differentiation, and qualification of raw materials. Finally, the HPLC method was proved to be useful for evaluation of raw material and finished products, besides satisfying the need for an analytical method that allows simultaneous determination of EFX, CFX, and LID, which can also be extended to other matrices and applications.

关键词： HPLC Physicochemical characterization Quality control Veterinary pharmaceutical formulation Raw material

Congenital hypothyroidism as a risk factor for hearing and parents’ knowledge about its impact on hearing

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Journal of Otology 2021年第2期16卷 71-79页

作者： Helida Braga Josilene Luciene Duarte Luciene da Cruz Fernandes Iza Cristina Salles Caio L.oliveira de Andrade Helton E.Ramos Cresio de aragao D.Alvesa Postgraduate Program in Interactive Processes of Organs and Systems Institute of Health Science-Federal University of BahiaAvenue Rector Miguel CalmonValley of Canela40110100SalvadorBahiaBrazil department of Speech Therapy Institute of Health Science-Federal University of SergipeAv.Marechal Rondon49100-000Sao CristovaoSergipeBrazil c department of Speech Therapy Institute of Health Science-Federal University of BahiaAvenue Rector Miguel CalmonValley of Canela40110100SalvadorBahiaBrazil department of Bioregulation Health&Sciences Institute-Federal University of BahiaAvenue Rector Miguel CalmonValley of Canela40110100SalvadorBahiaBrazil Medical School Institute of Health Science-Federal University of BahiaAvenue Rector Miguel CalmonValley of Canela40110100SalvadorBahiaBrazil

Aim:To evaluate the hearing of children with congenital hypothyroidism(CH)and to analyze the knowledge that parents’have on the possible auditory impacts of the ***:A total of 263 parents/guardians were interviewed about aspects of CH and *** evaluation was performed on 80 participants,divided into two groups:with CH(n?50)and without CH(n紏30).Clinical and laboratory CH data were obtained from medical records,pure tone auditory thresholds and acoustic reflexes were *** auditory data was compared between ***’s t-test and Chi-square were used for statistical analysis at a significance level of 5%(p0,05;p=0.026).There was a statistically significant difference between the auditory tone thresholds of the groups and between the levels of intensity necessary for the triggering of the acoustic *** group with CH presented the worst results(pdevelop damage to the auditory system involving retrocochlear structures when compared to healthy children,and that the disease may have been a risk factor for functional deficits without deteriorating hearing *** possible impacts of CH on hearing,when not treated early,should be more publicized among the parents/guardians of this population.

关键词： Auditory perception Hearing Congenital hypothyroidism Risk Factors Survey and questionnaire

Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression,anxiety and psychosis

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World Journal of Psychiatry 2022年第2期12卷 308-322页

作者： Ana Paula Michelin Michael H J Maes Thitiporn Supasitthumrong Chusak Limotai andressa Keiko Matsumoto Laura de oliveira Semeão João Victor de Lima Pedrão Estefânia Gastaldello Moreira Buranee Kanchanatawan Décio Sabbatini Barbosa Health Sciences Center State University of LondrinaLondrina 86038-440Brazil department of Psychiatry Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand department of Psychiatry Medical University of PlovdivPlovdiv 4004Bulgaria IMPACT Strategic Research Center Deakin UniversityGeelong 3220Australia Chulalongkorn Comprehensive Epilepsy Center of Excellence King Chulalongkorn Memorial HospitalThe Thai Red Cross SocietyBangkok 10330Thailand Division of Neurology Department of MedicineFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

BACKGROUND Temporal lobe epilepsy(TLE)is the most common focal epilepsy subtype in adults and is frequently accompanied by depression,anxiety and *** in total paraoxonase 1(PON1)status may occur in TLE and these psychiatric *** To examine PON1 status,namely Q192R PON1 genotypes and PON1 enzymatic activities,in *** We recruited 40 normal controls and 104 TLE patients,27 without comorbidities and 77 with comorbidities including mood disorders(n=25),anxiety disorders(n=27)and psychosis(n=25).RESULTS Four-(chloromethyl)phenyl acetate hydrolysis(CMPAase)and arylesterase activities were significantly lower in TLE and mesial temporal sclerosis(MTS)with and without psychiatric comorbidities than those in normal *** areas under the receiver operating characteristic curve of CMPAase were 0.893(0.037)for TLE and 0.895(±0.037)for *** least squares path analysis showed that there were specific indirect effects of PON1 genotype on TLE severity(P<0.0001)and psychopathology(P<0.0001),which were both mediated by lowered CMPAase activity,while arylesterase activity was not *** severity of TLE was significantly associated with psychopathology ***,PON1 CMPAase activity was inversely associated with Mini Mental State Examination *** The severity of TLE and comorbidities are to a large extent explained by reduced PON1 enzyme activities and by effects of the Q192R genotype,which are mediated by reduced CMPAase *** PON1 status plays a key role in the pathophysiology of TLE,MTS and psychiatric comorbidities by increasing the risk of oxidative ***1 enzyme activities are new drug targets in TLE to treat seizure frequency and psychiatric comorbidities.

关键词： Antioxidants Oxidative stress Neuroimmune Major depression Mood disorders Affective disorders

Quantification and determination of Starch in Diets Using Different Methodologies:Infrared Spectroscopy with Fourier Transformer,Laser Diffraction and Enzymatic Analysis

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American Journal of Analytical Chemistry 2017年第2期8卷 151-157页

作者： andressa Nathalie Nunes Eloisa de oliveira Simoes Saliba Dalton oliveira Fontes Ana Tereza Peret dell’Isola Tatiana Carolina Gomes Dutra de Souza Poliana Campos Esmaile Perceu Rocha Nunes Jaqueline Simoes Saliba Ludhiana Rosa Ferreira Universidade Federal de Minas Gerais(UFMG) Belo HorizonteBrazil

A digestibility experiment was conducted in the Animal Nutrition Laboratory of the Veterinary School of the Federal University of Minas Gerais (UFMG), Protocol ethics committee for work with animal experimentation CETEA/ UFMG 212/2010, in order to validate the instrumental techniques Laser Diffraction (Partica) and Infrared Spectroscopy with Fourier Transformer (FTIR) method, as replacement methods of the reference (Enzymatic Analysis) Technique, of starch quantification in diets of growing pigs. The experiment lasted 12 days (7 days of adaptation to the cage and diet and 5 days of total collection). Fifteen barrows with average weight of ±25 kg and 65 days old were used for this study. A completely randomized experimental design was adopted, with split plots and subplots. The plots were the diets (1—Reference, 2—Reference + inclusion of 30% micronized soybean and 3—Reference +30% substitution of plasma) and the subplots were the techniques (Partica, FTIR and Enzymatic Technique, with five repetitions (animals) per diet). The results obtained with the Partica and FTIR techniques were compared to the reference method. There was no statistical difference (p > 5%) between these techniques evaluated in comparison to the reference method to quantify starch. However, it was observed that the FTIR technique was different from the reference method for (p > 5%) overestimating the means of evaluated samples.

关键词： Instrumental Techniques Enzymatic Technique Quantification of Starch

Burn injury induces histopathological changes and cellproliferation in liver of rats

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World Journal of Hepatology 2016年第6期8卷 322-330页

作者： Jeferson Andre Bortolin Hananiah Tardivo Quintana Tabata de Carvalho Tome Flavia andressa Pidone Ribeiro Daniel Araki Ribeiro Flavia de oliveira department of Biosciences Federal University of São Paulo(UNIFESP)SantosSP 11060-001Brazil

AIM: To investigate effects of severe burn injury(BI) in rat liver through the histopathological and inflammatory markers analysis. METHODS: Forty-two male Wistar rats were distributed into two groups, control(C) and subjected to scald BI(SBI). The animals were euthanized one, four and 14 d post sham or 45% of the total body surface BI. Liver fragments were submitted to histopathological, morphoquantitative(hepatocyte area and cell density), ciclooxigenase-2(COX-2) immunoexpression, and gene expression [real-time polymerase chain reaction for tumor necrosis factor(TNF)-α, inducible nitric oxide synthase(i NOS) and caspase-3] methods. RESULTS: Histopathological findings showed inflammatory process in all periods investigated and hepatocyte degeneration added to increased amount of connective tissue 14 d post injury. Hepatocyte area, the density of binucleated hepatocytes and density of sinusoidal cells of SBI groups were increased when compared with control. COX-2 immunoexpression was stronger in SBI groups. No differences were found in TNF-α, i NOS and caspase-3 gene expression. CONCLUSION: BI induces histopathological changes, upregulation of COX-2 immunoexpression, and cell proliferation in liver of rats.

关键词： Burn injury Morphology Histophatology Liver Ciclooxigenase-2

Clinical Outcomes of Positive Newborns for COVID-19 in Rio de Janeiro, Brazil

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Open Journal of Obstetrics and Gynecology 2021年第12期11卷 1851-1861页

作者： Karina Martins-Cardoso Luana Ferreira Martins de Toledo Juliana Aparecida Souza Paz andressa Rangel de oliveira Lima Thaís Chrispim de Souza Giangiarulo Jéssica da Silva oliveira IPB COVID Workgroup Carla Carolina Teixeira Jones Zitenfeld Cardia Neto Giovanna Geórgia Pires Carrilho Vallim Shana Priscila Coutinho Barroso Laboratório de Biologia Molecular Instituto de Pesquisas Biomédicas Hospital Naval Marcílio Dias Rio de Janeiro Brasil Instituto de Bioquímica Médica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil UTI neonatal Clínica de Pediatria Hospital Naval Marcílio Dias Rio de Janeiro Brasil Serviç o de Patologia Hospital Naval Marcílio Dias Rio de Janeiro Brasil

The disease caused by the SARS-CoV-2 virus has spread very rapidly throughout the world, causing various clinical manifestations and affecting several organs and systems. However, the possibility of vertical transmission of COVID-19 in symptomatic pregnant women has been questioned. The aim of this work was to report cases of possible vertical transmission in pregnant women affected by the SARS-CoV-2 virus, as well as its clinical repercussions on the newborn. In this paper, we conducted a cross-sectional retrospective study by analyzing medical records of pregnant women admitted at the military hospital, in Rio de Janeiro, Brazil, diagnosed with COVID-19 and who had positive newborns. To evaluate epidemiological data, clinical manifestations, laboratorial and histopathological changes were related to such vertical transmission. Only six tested newborns were positive for COVID-19. The mothers had no respiratory symptoms, and the gestational age was at term, except for one newborn born prematurely due to detection of pericadial effusion. Three neonates had respiratory symptoms, requiring ventilatory support. None of the mothers or newborns died. During the pandemic, possible vertical transmission cases of infected pregnant women in the third trimester of pregnancy were observed. According to the case reports published in the literature, they illustrate phenotypes of neonatal involvement with varied clinical manifestations and severity;however, further scientific studies are needed to prove the effective vertical transmission of SARS-CoV-2 in positive pregnant women.

关键词： SARS-CoV-2 Infection Neonatal Outcomes Vertical Transmission

Immune response to Helicobacter pylori infection and gastric cancer development

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World Journal of Meta-Analysis 2021年第3期9卷 257-276页

作者： Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália oliveira e Silva Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45031900BahiaBrazil

Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(***)infection is the main risk factor for its *** note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this *** development of an inflammatory process against *** involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial *** process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper *** released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ***,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its *** addition,various repercussions related to some *** virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis.

关键词： Gastric cancer Helicobacter pylori Immune response Virulence factors Polymorphisms