Clinical Outcomes of Positive Newborns for COVID-19 in Rio de Janeiro, Brazil

作     者：Karina Martins-Cardoso Luana Ferreira Martins de Toledo Juliana Aparecida Souza Paz Andressa Rangel de Oliveira Lima Thaís Chrispim de Souza Giangiarulo Jéssica da Silva Oliveira IPB COVID Workgroup Carla Carolina Teixeira Jones Zitenfeld Cardia Neto Giovanna Geórgia Pires Carrilho Vallim Shana Priscila Coutinho Barroso Karina Martins-Cardoso;Luana Ferreira Martins de Toledo;Juliana Aparecida Souza Paz;Andressa Rangel de Oliveira Lima;Thaís Chrispim de Souza Giangiarulo;Jéssica da Silva Oliveira;IPB COVID Workgroup;Carla Carolina Teixeira;Jones Zitenfeld Cardia Neto;Giovanna Geórgia Pires Carrilho Vallim;Shana Priscila Coutinho Barroso

作者机构：Laboratório de Biologia Molecular Instituto de Pesquisas Biomédicas Hospital Naval Marcílio Dias Rio de Janeiro Brasil Instituto de Bioquímica Médica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil UTI neonatal Clínica de Pediatria Hospital Naval Marcílio Dias Rio de Janeiro Brasil Serviç o de Patologia Hospital Naval Marcílio Dias Rio de Janeiro Brasil 

出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)

年 卷 期：2021年第11卷第12期

页      面：1851-1861页

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

主　　题：SARS-CoV-2 Infection Neonatal Outcomes Vertical Transmission 

摘      要：The disease caused by the SARS-CoV-2 virus has spread very rapidly throughout the world, causing various clinical manifestations and affecting several organs and systems. However, the possibility of vertical transmission of COVID-19 in symptomatic pregnant women has been questioned. The aim of this work was to report cases of possible vertical transmission in pregnant women affected by the SARS-CoV-2 virus, as well as its clinical repercussions on the newborn. In this paper, we conducted a cross-sectional retrospective study by analyzing medical records of pregnant women admitted at the military hospital, in Rio de Janeiro, Brazil, diagnosed with COVID-19 and who had positive newborns. To evaluate epidemiological data, clinical manifestations, laboratorial and histopathological changes were related to such vertical transmission. Only six tested newborns were positive for COVID-19. The mothers had no respiratory symptoms, and the gestational age was at term, except for one newborn born prematurely due to detection of pericadial effusion. Three neonates had respiratory symptoms, requiring ventilatory support. None of the mothers or newborns died. During the pandemic, possible vertical transmission cases of infected pregnant women in the third trimester of pregnancy were observed. According to the case reports published in the literature, they illustrate phenotypes of neonatal involvement with varied clinical manifestations and severity;however, further scientific studies are needed to prove the effective vertical transmission of SARS-CoV-2 in positive pregnant women.