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Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： Kayla law Eduardo rosa Medina Garcia Chad Hastad Deborah Murray Pedro E.Urriola andres Gomez Department of Animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare *** challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous *** is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig ***,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic *** weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(P<0.01),with differences in community composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu *** Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc

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Histopathological impact of SARS-CoV-2 on the liver:Cellular damage and long-term complications

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World Journal of Gastroenterology 2024年第22期30卷 2866-2880页

作者： Alfonso Rodriguez-Espada Moises Salgado-de la Mora Briana Mariette Rodriguez-Paniagua Nathaly Limonde la rosa Monica Itzel Martinez-Gutierrez Santiago Pastrana-Brandes Nalu Navarro-Alvarez Department of Molecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico 03920Mexico Department of Internal Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico Department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States PECEM Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico 04360Mexico Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Coronavirus disease 2019(COVID-19),caused by the highly pathogenic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),primarily impacts the respiratory tract and can lead to severe outcomes such as acute respiratory distress syndrome,multiple organ failure,and *** extensive studies on the pathogenicity of SARS-CoV-2,its impact on the hepatobiliary system remains *** liver injury is commonly indicated by reduced albumin and elevated bilirubin and transaminase levels,the exact source of this damage is not fully *** mechanisms for injury include direct cytotoxicity,collateral damage from inflammation,drug-induced liver injury,and ischemia/***,evidence often relies on blood tests with liver enzyme *** this comprehensive review,we focused solely on the different histopathological manifestations of liver injury in COVID-19 patients,drawing from liver biopsies,complete autopsies,and in vitro liver *** present evidence of the direct impact of SARS-CoV-2 on the liver,substantiated by in vitro observations of viral entry mechanisms and the actual presence of viral particles in liver samples resulting in a variety of cellular changes,including mitochondrial swelling,endoplasmic reticulum dilatation,and hepatocyte *** ly,we describe the diverse liver pathology observed during COVID-19 infection,encompassing necrosis,steatosis,cholestasis,and lobular *** also discuss the emergence of long-term complications,notably COVID-19-related secondary sclerosing *** the histopathological liver changes occurring during COVID-19 infection is pivotal for improving patient recovery and guiding decision-making.

关键词： Liver SARS-CoV-2 COVID-19 Angiotensin-converting enzyme 2 Histopathology Liver biopsies Liver autopsy In vitro

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A 4-layer method of developing integrated sensor systems with labVIEW

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Journal of Measurement Science and Instrumentation 2013年第4期4卷 307-312页

作者：白江华陈静薇 John Freeouf andres la rosa Tan Kah Kee College Xiamen University Department of Physics Portland State University

System integrity is important for fast and accurate measurement and *** is widely used in education and *** labVIEW codes are hard to be read and shown because of their 2D *** order to simplify the programming,a 4-layer model of developing sensor or measurement systems with labVIEW is proposed in this *** purpose of this paper is to show the readers how to design simple,clear and strong automated systems with *** a Sensirion SHT75 humidity sensor and an NI USB6008 DAQ board as an example,this paper describes the steps of developing a sensor system from the physical layer to application layer in *** layer 2,port selection and signal regulation are *** layer 3,timing waveform analysis and synthesis,state diagram analysis,instruction set design,micro operation and fault tolerance designs are *** layer 4,data visualization is covered with a vivid *** found it was hard to show readers their labVIEW codes because many labVIEW codes occupy several screens.A layer model simplifies the programming,so one is able to show a medium size labVIEW code easily.

关键词： labVIEW sensor system layer model automatic system

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一个用于纳米压痕和应力测试的全自动原子力显微镜系统（英文）

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Journal of Measurement Science and Instrumentation 2018年第4期9卷 347-353页

作者：白江华 andres la rosa 波特兰州立大学物理系俄勒冈州97201

本文设计了一台专门用于纳米压痕和应力测试的原子力显微镜。显微镜的基座由三个步进电机控制,显微镜的精确运动由MCL压电陶瓷控制。显微镜的主动传感器由水晶音叉与粘在音叉上的探针组成,探针与待测样品之间的应力作用由一个精密超声... 详细信息

本文设计了一台专门用于纳米压痕和应力测试的原子力显微镜。显微镜的基座由三个步进电机控制,显微镜的精确运动由MCL压电陶瓷控制。显微镜的主动传感器由水晶音叉与粘在音叉上的探针组成,探针与待测样品之间的应力作用由一个精密超声波传感器来测量,传感器的信号由两台锁相放大器来处理。最终,所有数据由FPGA卡集成接收并传给电脑控制器。显微镜的主控制器用labVIEW编写,主要负责Z方向扫描、信号处理以及数据的图形化显示。控制器中植入了手动和自动两种模式,用来控制显微镜的运动和进行信号处理,在运行过程中用户可以在两种模式之间切换。调试与试运行结果显示,该原子力显微镜有简单灵活、使用方便等诸多优点。

关键词：原子力显微镜纳米压痕超声检测压电陶瓷驱动水晶音叉 labVIEW 锁相放大器 8051单片机

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一个由步进电机驱动的3支点扫描探针显微镜基座（英文）

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Journal of Measurement Science and Instrumentation 2017年第3期8卷 271-276页

作者：白江华 andres la rosa 波特兰州立大学物理系

设计了一个由3个步进电机驱动的扫描探针显微镜(Scanning probe microscope,SPM)基座。这个基座比普通的由一个电机驱动的基座要灵活,但基座的控制也相对复杂。基座的3个电动机由一个Arduino单片机来控制。在Arduino单片机里面还设计了... 详细信息

设计了一个由3个步进电机驱动的扫描探针显微镜(Scanning probe microscope,SPM)基座。这个基座比普通的由一个电机驱动的基座要灵活,但基座的控制也相对复杂。基座的3个电动机由一个Arduino单片机来控制。在Arduino单片机里面还设计了一个状态机,通过这个状态机单片机与电脑上位机和一个射频遥控器进行通信。另外,本项目还用两个5状态LED来显示有限状态机(Finite state machine,FSM)的不同状态以及电动机和基座的运动状态。最后,通过测试和调试,本基座在Z方向上能实现700纳米的机械控制分辨率。

关键词：扫描探针显微镜步进电机射频控制 labVIEW

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一个由labVIEW编写的扫描探针显微镜控制程序（英文）

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Journal of Measurement Science and Instrumentation 2018年第3期9卷 257-268页

作者：白江华 John L Freeouf andres la rosa 波特兰州立大学物理系美国俄勒冈州97201

本文的主要目的是通过具体示例的详细讲解,来降低自制扫描探针显微镜的门槛。本文用简约易懂的labVIEW编程实现了复杂的扫描探针显微镜的控制与图像处理的功能。本控制程序由三大模块用顺序结构完成。它们分别是设备初始化模块、扫描控... 详细信息

本文的主要目的是通过具体示例的详细讲解,来降低自制扫描探针显微镜的门槛。本文用简约易懂的labVIEW编程实现了复杂的扫描探针显微镜的控制与图像处理的功能。本控制程序由三大模块用顺序结构完成。它们分别是设备初始化模块、扫描控制与显像模块和设备安全关机模块。控制程序中最复杂、最关键的扫描控制与显像模块采用完全并行处理的方式实现。这种模块化设计,使主控程序简单明了;既方便修改又方便维护。并行处理模块主要有扫描区域调整与像素调整模块、Y方向扫描控制模块、X方向扫描控制与图像传输模块、扫描过程中参数再调整模块、扫描中断与紧急停机模块等组成。FPGA模块的主要功能是完成控制信号的输出与Z方向的实时反馈控制,在主控程序发出紧急停机命令时,FPGA模块将消除系统可能的振荡,把扫描探针恢复到初始位置以及关闭高压控制信号等等。文章最后,介绍了如何使用该控制器。杂乱无章、横七竖八的连线是labVIEW编程中的最大的诟病。当程序复杂时,这一问题更加严重。本文向读者展示了用labVIEW实现完全结构化与并行编程的方法;读者可以按照本文描述的编程技巧,用简单、易懂、易维护的模块化程序实现复杂的虚拟仪器应用。

关键词：扫描探针显微镜 labVIEW FPGA 多任务编程实时控制

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基于SR7265硬件的虚拟锁相放大器、频谱仪、阻抗计和半导体参数分析仪（英文）

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Journal of Measurement Science and Instrumentation 2018年第1期9卷 50-58页

作者：白江华 Freeouf L John andres la rosa 美国波特兰州立大学物理系

锁相放大器是用来测量微弱信号的专用仪器。即使噪音上千倍于被测信号,通过锁相放大器,也能得到精确结果。随着数字信号处理技术在仪器中的应用,可编程仪器变得越来越灵活。结合虚拟仪器的技术,论文通过对SR7265的硬件重新编程,在同一... 详细信息

锁相放大器是用来测量微弱信号的专用仪器。即使噪音上千倍于被测信号,通过锁相放大器,也能得到精确结果。随着数字信号处理技术在仪器中的应用,可编程仪器变得越来越灵活。结合虚拟仪器的技术,论文通过对SR7265的硬件重新编程,在同一个硬件上实现了虚拟锁相放大器、虚拟频谱仪、虚拟阻抗计和虚拟半导体参数分析仪等等功能。本虚拟仪器采用了4层的逻辑结构。同样的功能也在一个FPGA板上成功地部署。

关键词：虚拟锁相放大器虚拟频谱仪虚拟阻抗计虚拟半导体参数分析仪 4层逻辑结构

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo andres-Leon laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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