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Exploring impacts of COVID-19 on spatial and temporal patterns of visitors to Canadian Rocky Mountain National Parks from social media big data

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j.urnal of Forestry Research 2024年第4期35卷 13-33页

作者： Dehui Christina Geng amy Li j.eyu Zhang Howie W.Harshaw Christopher Gaston Wanli Wu Guangyu Wang National Park Research Centre Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada Faculty of Applied Science University of British ColumbiaVancouver V6T 1Z3Canada Paul G.Allen School of Computer Science&Engineering University of WashingtonSeattleWA 98195USA Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton T6G 2J9Canada Department of Wood Science Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada

COVID-19 posed challenges for global tourism *** in visitor temporal and spatial patterns and their associated determinants pre-and peri-pandemic in Canadian Rocky Mountain National Parks are *** was collected through social media programming and analyzed using spatiotemporal analysis and a geographically weighted regression(GWR)*** highlight that COVID-19 significantly changed park visitation *** tended to explore more remote areas *** GWR model also indicated distance to nearby trails was a significant influence on visitor *** results indicate that the pandemic influenced tourism temporal and spatial *** research presents a novel approach using combined social media big data which can be extended to the field of tourism management,and has important implications to manage visitor patterns and to allocate resources efficiently to satisfy multiple obj.ctives of park management.

关键词： Tourism management Social media big data National parks COVID-19 Geographical weighted regression

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang amy L.Strong Yuxiao Sun Lei Guo Conan j.an Alec C.Bancroft j. Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard j.hoon Lee Sowmya Ramesh Aaron W.j.mes David Hudson Kevin N.Dalby Lin Xu Robert j.Tower Benj.min Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal inj.ry remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse inj.ry-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

Stochastic SIS metapopulation models for the spread of disease among species in a fragmented landscape

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International j.urnal of Biomathematics 2016年第4期9卷 97-119页

作者： amy j. Ekanayake Department of Mathematics Western Illinois University 1 University Circle Maeomb Illinois 61455 USA

Two stochastic models are derived for a susceptible-infectious-susceptible epidemic spreading through a metapopulation： a continuous time Markov chain （CTMC） model and an It6 stochastic differential equation （SDE） model. The stochastic models are numerically compared. Close agreement suggests that computationally intense CTMC simulations can be approximated by simpler SDE simulations. Differential equations for the moments of the SDE probability distribution are also derived, the steady states are solved numerically using a moment closure technique, and these results are compared to simulations. The moment closure technique only coarsely approximates simulation results. The effect of model parameters on stability of the disease-free equilibrium is also numerically investigated.

关键词： Epidemic metapopulation Ito stochastic differential equation Markov chain moment closure.

A sting in the tail： the N-terminal domain of the androgen receptor as a drug target

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Asian j.urnal of Andrology 2016年第5期18卷 687-694页

作者： amy E Monaghan Iain j.McEwan School of Medicine Medical Sciences and Nutrition Institute of Medical Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD United Kingdom.

The role of androgen receptor （AR） in the initiation and progression of prostate cancer （PCa） is well established. Competitive inhibition of the AR ligand-binding domain （LBD） has been the staple of antiandrogen therapies employed to combat the disease in recent years. However, their efficacy has often been limited by the emergence of resistance, mediated through point mutations, and receptor truncations. As a result, the prognosis for patients with malignant castrate resistant disease remains poor. The amino-terminal domain （NTD） of the AR has been shown to be critical for AR function. Its modular activation function （AF-1） is important for both gene regulation and participation in protein-protein interactions. However, due to the intrinsically disordered structure of the domain, its potential as a candidate for therapeutic intervention has been dismissed in the past. The recent emergence of the small molecule EPI-O01 has provided evidence that AR-NTD can be targeted therapeutically, independent of the LBD. Targeting of AR-NTD has the potential to disrupt multiple intermolecular interactions between AR and its coregulatory binding partners, in addition to intramolecular cross-talk between the domains of the AR. Therapeutics targeting these protein-protein interactions or NTD directly should also have efficacy against emerging AR splice variants which may play a role in PCa progression. This review will discuss the role of intrinsic disorder in AR function and illustrate how emerging therapies might target NTD in PCa.

关键词： androgen receptor inhibitor intrinsically disordered structure N-terminal domain prostate cancer small molecules

e-VLBI observations of GRB 080409 afterglow with an Australasian radio telescope network

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Research in Astronomy and Astrophysics 2016年第11期16卷 1-6页

作者： Aquib Moin Philip G. Edwards Steven j. Tingay Chris j. Phillips Anastasios K. Tzioumis Shaun W. amy Tao An Mamoru Sekido Zhong-Xiang Wang Physics Department United Arab Emirates University RO. Box 15551 A1-Ain United Arab Emirates Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China International Centre for Radio Astronomy Research Curtin University Bentley WA Australia CSIRO Astronomy and Space Science P.O. Box 76 Epping NSW 2121 Australia Kashima Space Research Center National Institute of Information and Communications Technology (NICT) 893-1 Hirai Kashima 314-0014 Ibaraki Japan Key Laboratory of Radio Astronomy Chinese Academy of Sciences Nanjing 210008 China Osservatorio di Radio Astronomia Istituto Nazionale di Astrofisica Italy

Transcontinental e-VLBI observations were conducted in j.ne 2008 with telescopes in Australia, China and j.pan. Detections were made of the radio-loud quasar PKS B0727-115, which shows superlu- minal motion, and the intra-day variable quasar PKS B0524＋034. The latter source was used as a phase reference calibrator for observations at the position of the gamma-ray burst GRB 080409, for which an upper limit to the radio emission is set. Australia Telescope Compact Array data were also used to derive a limit on the radio flux density of the GRB afterglow. These observations demonstrate the capability to form a large Australasian radio telescope network for e-VLBI, with data transported and processed in realtime over high capacity networks. This campaign represents the first step towards more regular e-VLBI observations in this region.

关键词： techniques: interferometric -- galaxies: active -- gamma rays: bursts

j.xtacrine interaction of macrophages and bone marrow stromal cells induce interleukin-6 signals and promote cell migration

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Bone Research 2015年第2期3卷 100-111页

作者： j.a Chang amy j.Koh Hernan Roca Laurie K McCauley Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Department of Periodontology University of Florida College of Dentistry Department of Pathology University of Michigan Medical School

The bone marrow contains a heterogeneous milieu of cells, including macrophages, which are key cellular mediators for resolving infection and inflammation. Macrophages are most well known for their ability to phagocytose foreign bodies or apoptotic cells to maintain homeostasis; however, little is known about their function in the bone microenvironment. In the current study, we investigated the in vitro interaction of murine macrophages and bone marrow stromal cells （BMSCs）, with focus on the j.xtacrine induction of IL-6 signaling and the resultant effect on BMSC migration and growth. The j.xtacrine interaction of primary mouse macrophages and BMSCs activated IL-6 signaling in the co-cultures, which subsequently enhanced BMSC migration and increased BMSC numbers. BMSCs and macrophages harvested from IL-6 knockout mice revealed that IL-6 signaling was essential for enhancement of BMSC migration and increased BMSC numbers via j.xtacrine interactions. BMSCs were the main contributor of IL-6 signaling~ and hence activation of the IL-6/ gp130/STAT3 pathway. Meanwhile, macrophage derived IL-6 remained important for the overall production of IL-6 protein in the co-cultures. Taken together, these findings show the function of macmphages as co-inducers of migration and growth of BMSCs, which could directly influence bone formation and turnover.

关键词： BMSCs IL bone STAT cell

CLUSTERING PATENTS USING NON-EXHAUSTIVE OVERLAPS

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j.urnal of Systems Science and Systems Engineering 2010年第2期19卷 162-181页

作者： Charles V. TRAPPEY amy j.C. TRAPPEY Chun-Yi WU Department of Management Science National Chiao Tung University Taiwan China Department of Industrial Engineering & Management National Taipei University of Technology Taiwan China Department of lndustrial Engineering & Engineering Management National Tsing Hua University Taiwan China

Patent documents are unique external sources of information that reveal the core technology underlying new inventions. Patents also serve as a strategic data source that can be mined to discover state-of-the-art technical development and subsequently help guide R＆D investments. This research incorporates an ontology schema to extract and represent patent concepts. A clustering algorithm with non-exhaustive overlaps is proposed to overcome deficiencies with exhaustive clustering methods used in patent mining and technology discovery. The non-exhaustive clustering approach allows for the clustering of patent documents with overlapping technical findings and claims, a feature that enables the grouping of patents that define related key innovations. Legal advisors can use this approach to study potential cases of patent infringement or devise strategies to avoid litigation. The case study demonstrates the use of non-exhaustive overlaps algorithm by clustering US and j.pan radio frequency identification （RFID） patents and by analyzing the legal implications of automated discovery of patent infringement.

关键词： Data mining patent analysis patent infringement non-exhaustive overlap clustering ontology schema

Exercise-dependent regulation of glial cell line-derived neurotrophic factor （GDNF） expression in skeletal muscle and its importance for the neuromuscular system

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Frontiers in Biology 2013年第1期8卷 101-108页

作者： j.hn-Mary VIANNEY Monica j. MCCULLOUGH amy M. GYORKOS, j.hn M. SPITSBERGEN Department of Biological Scienees Western Michigan University Kalamazoo MI 49098-5410 USA

The focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor （GDNF） for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances maintenance and survival of both developing and mature motor neurons in vivo and in vitro. GDNF aids in neuromuscular j.nction formation, maintenance, and plasticity, where skeletal muscle-derived GDNF may be responsible for this phenomenon. Increased levels of physical activity can increase GDNF protein levels in skeletal muscle, where alterations in acetylcholine and acetylcholine receptor activation may be involved in regulation of these changes observed. With inactivity and disuse, GDNF expression shows different patterns of regulation in the central and peripheral nervous systems. Due to its potent effects for motor neurons, GDNF is being extensively studied in neuromuscular diseases.

关键词： glial cell line-derived neurotrophic factor neuromuscular j.nction motor neurons skeletal muscle

RE-ENGINEERING TRANSFORMER MAINTENANCE PROCESSES TO IMPROVE CUSTOMIZED SERVICE DELIVERY

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j.urnal of Systems Science and Systems Engineering 2011年第3期20卷 323-345页

作者： amy j.C. TRAPPEY Yong SUN Charles V. TRAPPEY Lin MA Department of Industrial Engineering and Engineering Management National Tsing Hua University Taiwan China Department of Industrial Engineering and Management National Taipei University of Technology Taiwan China School of Engineering Systems Queensland University of Technology Australia Department of Management Science National Chiao Tung University Taiwan China

The outage of a transformer in a power generation system will generally result in a shutdown of the entire system. Consequentially, large amounts of revenue are lost to the plant owner with a substantial negative impact on the civil community and industrial customers. This paper analyzes the current maintenance practices （i.e., an as-is process model） of a transformer manufacturing company, which provides maintenance services to power generation plants and reports the maj.r weaknesses in current business practices. The maintenance weaknesses include isolated processes and paper based information communication. These inefficient processes result in service delays, cost increases, and inappropriate responses to customers＇ specific requests and complaints. To improve the efficiency and flexibility of the entire transformer maintenance service system, an e-integration approach is implemented with three key tasks. First, the current business processes are re-engineered to provide an improved （to-be） business model. Then, we replace paper based documentation methods with an electronic filing system for efficient and cost-effective information exchange. Afterward, the improved process model is implemented as an Internet based system to enhance the interactions among the transformer manufacturer, end-users, and service contractors for customized maintenance services. The case study demonstrates that implementing the e-integration approach increases the efficiency and effectiveness of the customized maintenance services.

关键词： Business Processes Reengineering (BPR) asset maintenance power industry after-sales services transformers engineering