Exercise-dependent regulation of glial cell line-derived neurotrophic factor （GDNF） expression in skeletal muscle and its importance for the neuromuscular system
Exercise-dependent regulation of glial cell line-derived neurotrophic factor （GDNF） expression in skeletal muscle and its importance for the neuromuscular system作者机构：Department of Biological Scienees Western Michigan University Kalamazoo MI 49098-5410 USA
出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)
年 卷 期：2013年第8卷第1期
页 面：101-108页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 0836[工学-生物工程] 0713[理学-生态学] 071003[理学-生理学]
主 题：glial cell line-derived neurotrophic factor neuromuscular junction motor neurons skeletal muscle
摘 要：The focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor （GDNF） for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances maintenance and survival of both developing and mature motor neurons in vivo and in vitro. GDNF aids in neuromuscular junction formation, maintenance, and plasticity, where skeletal muscle-derived GDNF may be responsible for this phenomenon. Increased levels of physical activity can increase GDNF protein levels in skeletal muscle, where alterations in acetylcholine and acetylcholine receptor activation may be involved in regulation of these changes observed. With inactivity and disuse, GDNF expression shows different patterns of regulation in the central and peripheral nervous systems. Due to its potent effects for motor neurons, GDNF is being extensively studied in neuromuscular diseases.
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