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Unravelling cOVID-19 waves in Rio de Janeiro city:Qualitative insights from nonlinear dynamic analysis

Infectious Disease Modelling 2024年第2期9卷 314-328页

作者： Adriane S.Reis Laurita dos Santos américo c.nha jr Thaís c.R.O.Konstantyner Elbert E.N.Macao Institute of Science and Technology Federal University of São PauloSão Josédos CamposSPBrazil Physics Institute University of São PauloSão PauloSPBrazil Scientific and Technological Institute Universidade BrasilSão PauloSPBrazil Department of Applied Mathematics Rio de Janeiro State UniversityRio de JaneiroRJBrazil Paulista School of Medicine Federal University of São PauloSão PauloSPBrazil

Since the cOVID-19 pandemic was first reported in 2019,it has rapidly spread around the *** countries implemented several measures to try to control the virus *** healthcare system and consequently the general quality of life population in the cities have all been significantly impacted by the coronavirus *** different waves of contagious were responsible for the increase in the number of cases that,unfortunately,many times lead to *** this paper,we aim to characterize the dynamics of the six waves of cases and deaths caused by cOVID-19 in Rio de Janeiro city using techniques such as the Poincaréplot,approximate entropy,second-order difference plot,and central tendency *** results reveal that by examining the structure and patterns of the time series,using a set of non-linear techniques we can gain a better understanding of the role of multiple waves of cOVID-19,also,we can identify underlying dynamics of disease spreading and extract meaningful information about the dynamical behavior of epidemiological time *** findings can help to closely approximate the dynamics of virus spread and obtain a correlation between the different stages of the disease,allowing us to identify and categorize the stages due to different virus variants that are reflected in the time series.

关键词： cOVID-19 Nonlinear analysis Poincaréplot central tendency measure

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A brief history of the compendium of Physical Activities

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Journal of Sport and Health Science 2024年第1期13卷 3-5页

作者： Barbara E.Ainsworth Stephen D.Herrmann David R.Jacobs jr. Melicia c.Whitt-Glover catrine Tudor-Locke School of Exercise and Health Shanghai University of SportShanghai 200438China college of Health Solutions Arizona State UniversityPhoenixAZ 85003USA Kansas center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of Epidemiology and community Health University of MinnesotaMinneapolisMN 55455USA Gramercy Research Group KnightdaleNC 27545USA college of Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA

The compendium of Physical Activities(compendium)was developed to address consistent assignment of physical activity(PA)intensity values used in PA epidemiology research of the association between PA and health outcomes.1The known protective effects of PA on incident health outcomes traces to the mid-1900s,with over 50 studies examining coronary heart disease(cHD)as the outcome of interest.

关键词： epidemiology Activities protective

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2024 Adult compendium of Physical Activities:A third update of the energy costs of human activities

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Journal of Sport and Health Science 2024年第1期13卷 6-12页

作者： Stephen D.Herrmann Erik A.Willis Barbara E.Ainsworth Tiago V.Barreira Mary Hastert chelsea L.Kracht John M.Schuna jr. Zhenghui cai Minghui Quan catrine Tudor-Locke Melicia c.Whitt-Glover David R. Jacobs jr. Kansas center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA center for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA college of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and Health Shanghai University of SportShanghai 200438China Exercise Science Department Syracuse UniversitySyracuseNY 13244USA clinical Sciences Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of Exercise and Sport Science Oregon State UniversityCorvallisOR 97331USA college of Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA Gramercy Research Group KnightdaleNC 27545USA Division of Epidemiology and community Health School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Background:The compendium of Physical Activities was published in 1993 to improve the comparability of energy expenditure values assigned to self-reported physical activity(PA)across *** original version was updated in 2000,and again in 2011,and has been widely used to support PA research,practice,and public health ***:This 2024 update was tailored for adults 19-59 years of age by removing data from those≥60 *** a systematic review and supplementary searches,we identified new activities and their associated measured metabolic equivalent(MET)values(using indirect calorimetry)published since *** replaced estimated METs with measured values when ***:We screened 32,173 abstracts and 1507 full-text papers and extracted 2356 PA energy expenditure values from 701 *** added303 new PAs and adjusted 176 existing MET values and descriptions to reflect the addition of new data and removal of METs for older *** added a Major Heading(Video Games).The 2024 Adult compendium includes 1114 PAs(912 with measured and 202 with estimated values)across 22 Major ***:This comprehensive update and refinement led to the creation of The 2024 Adult compendium,which has utility across research,public health,education,and healthcare domains,as well as in the development of consumer health *** new website with the complete lists of PAs and supporting resources is available at https://***.

关键词： Adults Energy expenditure Exercise MET Physical Activities

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Fish culture in biofloc technology(BFT):Insights on stocking density carbon sources,c/N ratio,fish nutrition and health

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Aquaculture and Fisheries 2024年第4期9卷 522-533页

作者： Luciana Kelly Oliveira Wilson Wasielesky jr Marcelo Borges Tesser Laboratorio de Nutriçao de Organismos Aqu´aticos Instituto de OceanografiaUniversidade Federal do Rio Grande-FURG-Rua do Hotel02-CassinoRio Grande96201-900Brazil Laborat´orio de carcinocultura Instituto de OceanografiaUniversidade Federal do Rio Grande-FURG-Rua do Hotel02-CassinoRio Grande96201-900Brazil

The growth of aquaculture demands intense consumption of formulated foods,scarce natural resources such as water and *** increase in aquaculture production needs to be sustainable in several aspects of the activity,including the use of more sustainable farming systems that provide reduced water demand,less space dependence for increased production,and availability of complementary natural *** this perspective,the biofloc system(BFT),presents itself as a more friendly cultivation technology as a way to mitigate some impacts of aquaculture *** research has been carried out,addressing different aspects important to the production of fish in *** this review,we address how stocking density,carbon sources and carbon nitrogen ration(c/N)affect animal performance and the nutritional value of bioflocs;the use of microbial aggregates as“in situ”and“ex situ”food and the benefits in feed conversion,and their influence on the immune system and disease resistance.

关键词： Biofloc technology Aquaculture system Natural food Nutritional value Fish health

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中国急性冠状动脉综合征患者治疗和预后的地区差异:来自国家胸痛中心的证据

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Science Bulletin 2024年第9期69卷 1302-1312页

作者：周书铎张岩董雪洁马郡雄李娜史红 Sidney c.Smith jr 金音子许铭向定成郑志杰霍勇 Department of Global Health Peking University School of Public HealthBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing100871China Department of cardiology Peking University First HospitalBeijing 100034China chinese Medical Association Beijing 100052China Division of cardiovascular Medicine School of MedicineUniversity of North Carolina at Chapel HillNorth Carolina 27599-3140USA Department of cardiology General Hospital of Southern Theater Command of PLAGuangzhou 510010China

Regional variations in acute coronary syndrome(AcS) management and outcomes have been an enormous public health issue. However, studies have yet to explore how to reduce the variations. The National chest Pain center Program(NcPcP) is the first nationwide, hospital-based, comprehensive, continuous quality improvement program for improving the quality of care in patients with AcS in china. We evaluated the association of NcPcP and regional variations in AcS healthcare using generalized linear mixed models and interaction analysis. Patients in the Western region had longer onset-to-first medical contact(FMc) time and time stay in non-percutaneous coronary intervention(PcI) hospitals, lower rates of PcI for ST-elevation myocardial infarction(STEMI) patients, and higher rates of medication *** in central regions had relatively lower in-hospital mortality and in-hospital heart failure *** in the door-to-balloon time(Dto B) and in-hospital mortality between Western and Eastern regions were less after accreditation(β =-8.82, 95% confidence interval(cI)-14.61 to-3.03;OR = 0.79, 95%cI 0.70 to 0.91). Similar results were found in differences in Dto B time, primary PcI rate for STEMI between central and Eastern regions. The differences in PcI for higher-risk non-ST-segment elevation acute coronary syndrome(NSTE-AcS) patients among different regions had been ***, the differences in medication use between Eastern and Western regions were higher after accreditation. Regional variations remained high in this large cohort of patients with AcS from hospitals participating in the NcPcP in china. More comprehensive interventions and hospital internal system optimizations are needed to further reduce regional variations in the management and outcomes of patients with AcS.

关键词： Acute coronary syndromes Quality improvement Regional variations Quality metrics

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Geothermo-mechanical alterations due to heat energy extraction in enhanced geothermal systems: Overview and prospective directions

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Deep Underground Science and Engineering 2024年第3期3卷 256-268页

作者： Mary c.Ngoma Oladoyin Kolawole Olufemi Olorode John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkUSA Department of Petroleum Engineering Louisiana State UniversityBaton RougeUSA

Geothermal energy from deep underground (or geological) formations,with or without its combination with carbon capture and storage (ccS),can be a key technology to mitigate anthropogenic greenhouse gas emissions and meet the 2050 net‐zero carbon emission *** resources in low‐permeability and medium‐and high‐temperature reservoirs in sedimentary sequence require hydraulic stimulation for enhanced geothermal systems (EGS).However,fluid migration for geothermal energy in EGS or with potential cO_(2) storage in a cO_(2)‐EGS are both dependent on the in situ flow pathway network created by induced fluid *** thermo‐mechanical interactions can be complex and induce varying alterations in the mechanical response when the working fluid is water (in EGS) or supercritical cO_(2)(in cO_(2)‐EGS),which could impact the geothermal energy recovery from geological ***,there is a need for a deeper understanding of the heat extraction process in EGS and cO_(2)‐*** study presents a systematic review of the effects of changes in mechanical properties and behavior of deep underground rocks on the induced flow pathway and heat recovery in EGS reservoirs with or without cO_(2) storage in cO_(2) ‐***,we proposed waterless‐stimulated EGS as an alternative approach to improve heat energy extraction in ***,based on the results of our literature review and proposed ideas,we recommend promising areas of investigation that may provide more insights into understanding geothermo‐mechanics to further stimulate new research studies and accelerate the development of geothermal energy as a viable clean energy technology.

关键词： cO_(2)-EGS enhanced geothermal systems geomechanics geothermal energy underground thermal energy

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ca^(2+) binding to the c_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & cell 2024年第4期15卷 305-312页

作者： Han chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.chepurwar Regina célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,jr. Fritz Benseler Nils Brose Kathrin Kusch carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany collaborative Research center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIc Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging cluster of Excellence(MBExc) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHcs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-c_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHcs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

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Family Medicine and community Health 2024年第S3期12卷 43-51页

作者： William B Ventres Leslie A Stone Johanna F Shapiro cynthia Haq Jéssica R B Leao Donald E Nease jr Liz Grant Stewart W Mercer John c M Gillies Pablo González Blasco Maria Auxiliadora c De Benedetto Graziela Moreto Marcelo R Levites Jennifer E DeVoe William R Phillips Jane M Uygur Thomas R Egnew colette S Stanley Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of Medicine University of Sao PauloSao PauloBrazil Family Medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBRamFA-Medical Education and Humanism Sao PauloBrazil Family Medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family Medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal Medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family Medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘Reflective practice in action’,‘The doctor as drug—Balint groups’,‘cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’May readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

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Assessment of nano-to-micro-scale geomechanical properties and their time-dependent behavior: current status and progressive perspectives

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第1期3卷 1-15页

作者： Mary c.Ngoma Oladoyin Kolawole John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA

Rocks can deform at varying scales(nano-,micro-and macro-scale)under different temperatures,pressures,stresses,and time ***-core scale(nano-to micro-scale)changes in rock properties can influence local(fine-scale)and bulk scale(macro-scale)rock ***,there is a lack of comprehensive knowledge on how rock deformation at sub-core scale(i.e.,nano-to micro-scale)is assessed and its potential to accurately predicte and estimate the macro-scale mechanical behavior of *** study presents a comprehensive and forward-leaning review of the assessment of nano-scale and micro-scale rock mechanical parameters,their timedependent behavior,and potential applications in rock ***,we highlighted the key findings based on experimental and numerical methods for evaluating rock mechanical parameters,and presented the limitations of these ***,we discussed the reliability of sub-core scale mechanical assessments in predicting macromechanical(larger-scale)properties and the behavior of rocks in ***,we offer recommendations to advance investigations focused on rock mechanical assessments at these smaller scales and provide a more accurate characterization at the sub-core scale.

关键词： Rock mechanics Rock deformation Nanomechanics Rock creep Rock engineering

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Automating selective area electron diffraction phase identification using machine learning

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Journal of Materiomics 2024年第4期10卷 896-905页

作者： M.Mika N.Tomczak c.Finney J.carter A.Aitkaliyeva Nuclear Engineering Program in Department of Materials Science University of Florida100 Rhines HallGainesville32611FLUSA Department of Materials Science&Engineering Case Western Reserve University2111 Martin Luther King Jr DrCleveland44106OHUSA

Selective area electron diffraction(SAED)patterns can provide valuable insight into the structure of a ***,the manual identification of collected patterns can be a significant bottleneck in the overall phase classification *** this work,we utilize the recent advances in computer vision and machine learning(ML)to automate the indexing of SAED *** performance of six different ML algorithms is demonstrated using metallic plutonium-zirconium *** most successful approach trained a neural network(NN)to make a classification of the phase and zone axis,and then utilized a second NN to synthesize multiple independent predictions of different tilts in a single sample to make an overall phase *** results demonstrate that automated SAED phase identification using ML is a viable route to accelerate materials characterization.

关键词： Selective area electron diffraction Machine learning Phase identification Metallic fuels Pu alloys

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