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Colectomy is a risk factor for venous thromboembolism in ulcerative colitis

World Journal of Gastroenterology 2015年第4期21卷 1251-1260页

作者： Gilaad G Kaplan allen lim Cynthia H Seow Gordon W Moran Subrata Ghosh Yvette Leung Jennifer Debruyn Geoffrey C Nguyen James Hubbard Remo Panaccione Inflammatory Bowel Disease Clinic University of CalgaryCalgary AB T2N 4N1Canada Division of Gastroenterology University of CalgaryCalgary AB T2N 4N1Canada Departments of Medicine University of CalgaryCalgary AB T2N 4N1Canada Community Health Sciences University of CalgaryCalgary AB T2N 4N1Canada Paediatrics University of CalgaryCalgary AB T2N 4N1Canada Mount Sinai Centre for Inflammatory Bowel Disease University of TorontoToronto ON M5SCanada Institute for Clinical Evaluative Sciences Toronto ON M5SCanada

AIM: To compare venous thromboembolism(VTE) in hospitalized ulcerative colitis(UC) patients who respond to medical management to patients requiring colectomy. METHODS: Population-based surveillance from 1997 to 2009 was used to identify all adults admitted to hospital for a flare of UC and those patients who underwent colectomy. All medical charts were reviewed to confirm the diagnosis and extract clinically relevant information. UC patients were stratified by:(1) responsive to inpatient medical therapy(n = 382);(2) medically refractory requiring emergent colectomy(n = 309); and(3) elective colectomy(n = 329). The primary outcome was the development of VTE during hospitalization or within 6 mo of discharge. Heparin prophylaxis to prevent VTE was assessed. Logistic regression analysis determined the effect of disease course(i.e., responsive to medical therapy, medically refractory, and elective colectomy) on VTE after adjusting for confounders including age, sex, smoking, disease activity, comorbidities, extent of disease, and IBD medications(i.e., corticosteroids, mesalamine, azathioprine, and infliximab). Point estimates were presented as odds ratios(OR) with 95%***: The prevalence of VTE among patients with UC who responded to medical therapy was 1.3% and only 16% of these patients received heparinprophylaxis. In contrast, VTE was higher among patients who underwent an emergent(8.7%) and elective(4.9%) colectomy, despite greater than 90% of patients receiving postoperative heparin prophylaxis. The most common site of VTE was intra-abdominal(45.8%) followed by lower extremity(19.6%). VTE was diagnosed after discharge from hospital in 16.7% of cases. Elective(adjusted OR = 3.69; 95%CI: 1.30-10.44) and emergent colectomy(adjusted OR = 5.28; 95%CI: 1.93-14.45) were significant risk factors for VTE as compared to medically responsive UC patients. Furthermore, the odds of a VTE significantly increased across time(adjusted OR = 1.10; 95%CI: 1.01-1.20). Age, sex, c

关键词： Inflammatory bowel diseases Ulcerative colitis Dee

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee Su Bin lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Characterizations of organic compounds in diesel exhaust particulates

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Journal of Environmental Sciences 2015年第8期27卷 171-183页

作者： Jaehyun lim Cheolsoo lim Sangkyun Kim Jihyung Hong Division of Global Environment Research National Institute of Environmental Research Department of Climate and Air Quality Research National Institute of Environmental Research

To characterize how the speed and load of a medium-duty diesel engine affected the organic compounds in diesel particle matter（PM） below 1 μm, four driving conditions were examined. At all four driving conditions, concentration of identifiable organic compounds in PM ultrafine（34–94 nm） and accumulation（94–1000 nm） modes ranged from 2.9 to 5.7 μg/m3 and 9.5 to 16.4 μg/m3, respectively. As a function of driving conditions, the non-oxygencontaining organics exhibited a reversed concentration trend to the oxygen-containing organics. The identified organic compounds were classified into eleven classes： alkanes,alkenes, alkynes, aromatic hydrocarbons, carboxylic acids, esters, ketones, alcohols, ethers,nitrogen-containing compounds, and sulfur-containing compounds. At all driving conditions,alkane class consistently showed the highest concentration（8.3 to 18.0 μg/m3） followed by carboxylic acid, esters, ketones and alcohols. Twelve polycyclic aromatic hydrocarbons（PAHs）were identified with a total concentration ranging from 37.9 to 174.8 ng/m3. In addition, nine nitrogen-containing polycyclic aromatic compounds（NPACs） were identified with a total concentration ranging from 7.0 to 10.3 ng/m3. The most abundant PAH（phenanthrene）and NPACs（7,8-benzoquinoline and 3-nitrophenanthrene） comprise a similar molecular（3 aromatic-ring） structure under the highest engine speed and engine load.

关键词： Diesel particle matter Organic compounds Polycyclic aromatic hydrocarbons Nitrogen-containing polycyclic aromatic compounds

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Landau damping of twisted waves in Cairns distribution with anisotropic temperature

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Plasma Science and Technology 2021年第8期23卷 18-28页

作者： Sunggeun LEE Hankwon lim School of Energy and Chemical Engineering UNIST50UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea

The consideration of orbital angular momentum of an electric field(twisted mode)is applied to the kinetic theory of *** linearized Vlasov–Poisson equation is solved for the anisotropic thermal distributed bi-Maxwellian and Cairns distributions of electrons to obtain the damping rates of twisted *** dispersion relation and Landau damping of Langmuir twisted modes are *** presence of twisted modes opens up two more possibilities in Landau damping and dispersion *** may generate a mixture with ion sound *** seems to play the role of a control parameter of Landau damping.

关键词： Landau damping Cairns distribution function anisotropic

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Emissions of Er3+ and Yb3+ co-doped SrZrO3 nanocrystals under near-infrared and near-ultraviolet excitations

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Journal of Advanced Ceramics 2020年第4期9卷 413-423页

作者： Hyeontae lim Juyeong lim Soyoung Jang Y.S.Lee Department of Physics Soongsil UniversitySeoul06978Republic of Korea

In this study,the upconversion(UC)emissions of Er3+and Yb3+co-doped SrZrO3 nanocrystals(NCs)were investigated in terms of the thermal annealing temperature and concentration of Er3+ions and compared with the emissions under a near-ultraviolet(near-UV)*** NCs were synthesized by the combustion method,and the as-synthesized NCs were post-annealed at high *** X-ray diffraction patterns revealed that the grain sizes and crystallinity degrees of the samples increased with increasing annealing *** photoluminescence spectra of our samples exhibited strong green and very weak red emissions with the near-UV excitation,originating from the f-f transitions in the Er3+***,under near-infrared(near-IR)excitation,we identified sizable visible emissions at 525,547,and 660 nm in our NCs,which indicated that the UC process successfully occurred in our *** UC emissions were maximized in the NCs with an Er3+concentration of 0.02 and thermal annealing at 1000°*** found that the intensity ratios of red to green emissions increased with increasing annealing *** discussed the differences in the emissions between near-UV and near-IR excitations.

关键词： Er3+and Yb3+co-doped SrZrO3 upconversion downshifting nanocrystals combustion method annealing temperature

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On p^(j)-rank of Even K-groups of Rings of Integers

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2481-2496页

作者： Meng Fai lim School of Mathematics and Statistics&Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan 430079P.R.China

Let L/F be a finite Galois extension of number fields of degree n and let p be a prime which does not divide *** shall study the p^(j)-rank of K_(2i)(O_(L))via its Galois module structure following the approaches of Iwasawa and Komatsu–*** the way,we generalize previous observations of Browkin,Wu and Zhou on K_(2)-groups to higher even *** also give examples to illustrate our ***,we apply our discussion to refine a result of Kitajima pertaining to the p-rank of even K-groups in the cyclotomic Z_(l)-extension,where l≠p.

关键词： p^(j)-rank even K-groups rings of integers

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Cydodextrin conjugated ferritin nanocages reduce intracellular cholesterol level in foam cells

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Nano Research 2019年第12期12卷 2925-2932页

作者： Samyukta Ravishankar Sierin lim School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveBlk N1.3Singapore 637457Singapore NTU-Northwestem Institute for Nanomedicine Nanyang Technological University50 Nanyang DriveBlk N3.1Singapore 637553Singapore

Accumulation of lipid-laden macrophages(foam cells)is characteristic of atherosclerosis developme nt in the arterial *** nano cages have been found to passively accumulate in the atherosclerotic *** has been actively investigated as a carrier for contrast agents in atherosclerosis diag no *** dem on strate the pote ntial of ferritin as a carrier for therapeutic molecules to mediate cholesterol reducti on from foam *** molecules are chemically conjugated to the ferritin anocages surface or encapsulated within the nanocages using metal co-loadi ng *** cyclodextrin-conjugated ferriti n has nano molar affinity to cholesterol *** of foam cells with the conjugates shows decreased levels of intracellular accumulated *** preferential localization of ferritin to foam cells is due to transferrin receptor-mediated endocytosis *** findings show that ferritin nanocages as carriers localize cyclodextrin molecules to foam cells which mediate intracellular cholesterol reductio n,thus highlight!ng its potential use as a therapeutic agent.

关键词： cyclodextrin ferritin protein nanocages cholesterol sequestration foam cells

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Architecture for mobile group communication in campus environment

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Frontiers of Computer Science 2013年第4期7卷 505-513页

作者： Yujin lim Sanghyun AHN Department of Information Media University of Suwon Hwaseong 445-743 Korea School of Computer Science University of Seoul Seoul 130-743 Korea

The demand for group communication using smart devices in campus environment is increasing rapidly. In this paper, we design an architecture for a mobile group communication system （MGCS） on campus by using Wi-Fi networks and smart devices. The architecture is composed of a web-based system and a smart device based mobile system. Through the systems, users on campus create community/mobile group, maintain dynamic group membership, and reliably deliver the message to other users. We use the common features of many smart devices to develop a prototype that works on off-the-shelf hardware. In the experimental section, we demonstrate our system using various real scenarios which can occur in university campuses.

关键词： smart campus smartphone location tracking,mobile community

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Polarity control of carrier injection for nanowire feedback field-effect transistors

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Nano Research 2019年第10期12卷 2509-2514页

作者： Doohyeok lim Sangsig Kim Department of Electrical Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea

We present polarity control of the carrier injection for a feedback field-effect transistor(FBFET)with a selectively thinned p^+-i-n^+Si nanowire(SiNW)channel and two separate *** SiNW FBFET can be reconfigured in the p-or n-channel operation modes via simple control of electric *** two separate gates induce potential barriers in the SiNW channel for selective control of the carrier *** contrast to previously reported rec on figurable tran sistors,our tran sistor features symmetry of the electrical characteristics for the p-and n-cha nnel operation ***-feedback operation of the SiNW FBFET provides superior switching characteristics for the p-and n-type 8nfigurations,including the on/off ratios(~10^5)and subthreshold swings(1.36-1.78 mV/dec).This novel tran sistor is a promising can didate for reconfigurable electro nics.

关键词： silicon nanowire reconfigurable transistor positive-feedback loop separate gate

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Hydrodynamic metasurface for programming electromagnetic beam scanning on the Azimuth and elevation planes

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Microsystems & Nanoengineering 2022年第2期8卷 217-225页

作者： Aqeel Hussain Naqvi Sungjoon lim School of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea

The development of multifunctional and reconfigurable metasurfaces capable of manipulating electromagnetic waves has created new opportunities for various exciting *** efforts have been applied to exploiting active metasurfaces with properties that can be controlled by externally controlling active ***,previous approaches have poor switch isolation,power handling limitations due to nonlinear effects,and complex biasing ***,dynamically tunable metasurfaces have become a burgeoning field in many research *** paper reports a hydrodynamic metasurface(HMS)that can be programmed to realize electromagnetic beam scanning on the azimuth and elevation *** proposed HMS platform incorporates four micropumps,each controlling four metasurface elements via microfluidic channels,built into the HMS *** proposed platform regulates microfluidic flow through micropumps,causing irregularities in incident wave transmission *** HMS was built as a proof of concept,and far-field scanning experiments were *** and experimental results verify the feasibility of electromagnetic beam scanning using a hydrodynamic *** work advances metasurface research,with very high potential for wide-ranging application and a promising route for replacing bulky cascading active components.

关键词： surface. beam programming

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