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Toward understanding Cretaceous climate An updated review

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science China Earth sciences 2017年第1期60卷 5-19页

作者： William W. hay Department of Geological sciences and University Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New data and ideas are changing our view of conditions during the *** of the continents was lower than originally thought,eliminating the'cold continental interior paradox'of fossils of plants that could not tolerate freezing occurring in regions indicated by climate models to be well below freezing in *** controversy over the height of Cretaceous sea levels has been resolved by knowledge of the effects of passage of the subducted slab of the Farallon Plate beneath the North American *** cause of shorter term sea level changes of the order of 30 to 50 meters is not because of growth and decay of ice sheets,but more likely the filling and release of water from groundwater reservoirs and lakes although there may have been some ice in the Early and latest *** dioxide was not the only significant greenhouse gas;methane contributed significantly to the warmer *** of very warm tropical ocean temperatures(>40℃)have implications for the nature of plant life on land limited by Rubisco *** land surfaces were much wetter than has been thought,with meandering rivers and many oxbow lakes providing habitat for large dinosaurs.A major rethinking of the nature of conditions on a warmer Earth is underway,and a new suite of paleoclimate simulations for the Cretaceous is needed.

关键词： Cretaceous Paleogeography Paleotopography sea level Greenhouse Paleohydrology Paleoclimate

A comparison of strategic mine planning approaches for in-pit crushing and conveying, and truck/shovel systems

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International Journal of Mining science and Technology 2018年第2期28卷 205-214页

作者： M.Nehring P.F.Knights M.s.Kizil E.hay school of Mechanical and Mining Engineering The University of Queensland

In a global environment where energy and labor are becoming increasingly expensive, continuous mining systems such as In-Pit Crushing and Conveying(IPCC) systems have been advanced as offering a real alternative to conventional truck haulage systems. The implementation of IPCC systems in hard rock operations in open pit mines however requires different and more comprehensive planning approaches in order to adequately reflect the practical aspects associated with these. This paper investigates the impact that these approaches may have on the implementation of IPCC systems on a basic metalliferous deposit amenable to open pit exploitation. A strategic life of mine plan to provide numerous economic indicators for each approach is analyzed and compared to traditional truck haulage systems. The mine planning and evaluation process highlights the increased overall resource recovery that may accompany the use of IPCC systems. This investigation also provides insights into the issues associated with IPCC and the scale and type of operation and orebody that is likely to provide a feasible alternative to truck haulage.

关键词： In pit crusher conveyor systems strategic mine planning Resource recovery surface metalliferous mining Mine optimization Truck and shovel

Gut microbiome alters functions of mutant p53 to promote tumorigenesis

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signal Transduction and Targeted Therapy 2020年第1期5卷 491-492页

作者： Harry Cheuk hay Lau Jun Yu Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinN.T.Hong Kong

In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal *** demonstrated the substantial plasticity of mutant p53 in WNT-driven tumo... 详细信息

关键词： tumorigenesis involvement al

Physicochemical characterization of forest and sugarcane leaf combustion’s particulate matters using electron microscopy,EDs,XRD and TGA

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Journal of Environmental sciences 2021年第1期33卷 296-310页

作者： hay Mon Oo Preechar Karin Nuwong Chollacoop Katsunori Hanamura Faculty of Engineering King Mongkut's Institute of Technology LadkrabangBangkok 10520Thailand National Metal and Materials Technology Center National Science and Technology Development AgencyPathum Thani 12120Thailand school of Engineering Tokyo Institute of TechnologyTokyo 152-8552Japan

Physical characteristics and quantitative elemental composition of PM and residual ash produced from sugarcane leaves(sCL)combustion were investigated using TEM-EDs compared with forest leaves(FRL).sEM-EDs was used to analyze the microstructure and chemical composition of biomass raw leaves and *** analysis was also performed to investigate the characterization of the crystalline nanostructure,structure of PM,and residual ash compared to the TEM image processing *** oxidation kinetics of biomass raw materials,PM,and residual ash were investigated by *** morphology of fine and ultrafine agglomerate structure of sCL soot and residual ash are not significantly different from the FRL soot and residual *** average diameter sizes of single primary nanoparticles of sCL and FRL soot are approximately 37 nm and 35 nm,while the sizes of residual ash are about 18 nm and 22 nm,*** single primary nanoparticles of soot are mainly composed of curve line crystallites of carbon fringes,while residual ash is composed of straightline lattice *** average fringe lengths of sCL and FRL soot are about 1.25 nm and 1.04 nm from the outer shell and 0.89 nm and 0.74 nm from the inner *** interlayer spacing of curve line carbon fringes of sCL and FRL soot is approximately 0.359 nm and 0.362 nm by the TEM image analysis and it was matched with XRD *** biomass PMs are mainly composed of soot,si,Ca,and K compounds:siO_(2),CaCO3,and KCl.

关键词： Biomass combustion Particulate matter soot Ashes TEM XRD TGA

A theoretical framework for improved fire suppression by linking management models with smart early fire detection and suppression technologies

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Journal of Forestry Research 2024年第5期35卷 1-13页

作者： Li Meng Jim O’Hehir Jing Gao stefan Peters Anthony hay University of south Australia AdelaideSAAustralia Esk spatial InvermayTASAustralia

Bushfires are devastating to forest managers,owners,residents,and the natural *** tech-nological advances indicate a potential for faster response times in terms of detecting and suppressing ***,to date,all these technologies have been applied in *** paper introduces the latest fire detection and sup-pression technologies from ground to *** operations research method was used to assemble these technologies into a theoretical framework for fire detection and *** framework harnesses the advantages of satellite-based,drone,sensor,and human reporting technologies as well as image processing and artificial intelligence machine *** study concludes that,if a system is designed to maximise the use of available technologies and carefully adopts them through complementary arrangements,a fire detection and resource suppression system can achieve the ultimate aim:to reduce the risk of fire hazards and the dam-age they may cause.

关键词： Forest fire Resource suppression smart fire detection and suppression system Forest fire management Holistic system

Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis

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signal Transduction and Targeted Therapy 2020年第1期5卷 747-748页

作者： Xiaoxing Li Harry Cheuk hay Lau Jun Yu Institute of Precision Medicine First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinNewTerritoriesHong Kong

In a recent study in Nature,Wu et *** a fundamental host–microbe interaction that is crucially involved in responding to dietary change thereby maintaining healthy intestinal dynamics.1 They demonstrated that HDAC3 a... 详细信息

关键词： metabolism HDAC3 homeostasis

Gut Microbiome in Colorectal Cancer:Clinical Diagnosis and Treatment

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 84-96页

作者： Yali Liu Harry Cheuk-hay Lau Wing Yin Cheng Jun Yu Institute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong Kong Special Administrative Region 999077China

Colorectal cancer(CRC)is one of the most frequently diagnosed cancers and the leading cause of cancer-associated *** studies have shown that both genetic and environmental risk factors contribute to the development of *** metagenomic studies of CRC have identified gut dysbiosis as a fundamental risk factor in the evolution of colorectal *** enormous efforts and substantial progresses have been made in understanding the relationship between human gut microbiome and CRC,the precise mechanisms involved remain *** data have shown a direct causative role of the gut microbiome in DNA damage,inflammation,and drug resistance in CRC,suggesting that modulation of gut microbiome could act as a powerful tool in CRC prevention and ***,we provide an overview of the relationship between gut microbiome and CRC,and explore relevant mechanisms of colorectal *** next highlight the potential of bacterial species as clinical biomarkers,as well as their roles in therapeutic *** limiting the clinical translation of gut microbiome and strategies for resolving current challenges are further discussed.

关键词： Gut microbiome Colorectal cancer Diagnostic biomarker Immunotherapy Chemotherapy

Mathematical Modeling of Cell Polarity Establishment of Budding Yeast

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Communications on Applied Mathematics and Computation 2024年第1期6卷 218-235页

作者： Yue Liu Jun Xie hay-Oak Park Wing-Cheong Lo Department of Mathematics City University of Hong KongTat Chee AvenueKowloonHong KongChina Department of Molecular Genetics The Ohio State UniversityColumbusOHUSA

The budding yeast saccharomyces cerevisiae is a powerful model system for studying the cell polarity *** cell polarization process is regulated by signaling molecules,which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or *** of these signaling molecules involves complex regulation,so the mathematical models become a useful tool to investigate the mechanism behind the *** this review,we discuss how mathematical modeling has shed light on different regulations in the cell *** also propose future applications for the mathematical modeling of cell polarization and morphogenesis.

关键词： Budding yeast Cdc42 Morphogenesis septin Mathematical models

Mapping land subsidence over the eastern Beijing city using satellite radar interferometry

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International Journal of Digital Earth 2018年第5期11卷 504-519页

作者： Zheyuan Du Linlin Ge Alex hay-Man Ng Li Xiaojing Liyuan Li Geoscience and Earth Observing system Group(GEOs) School of Civil and Environmental EngineeringUNSW AustraliaSydneyAustralia Department of surveying Engineering Guangdong University of TechnologyGuangzhouPeople’s Republic of China

Beijing City has suffered from groundwater-induced subsidence since the late 1930s and the over-exploration of groundwater could lead to subsidence as much as−12.0 cm yr−*** studies on the ground deformation at Beijing City mainly focused on the period before the year of 2014 when a mega-engineering project was launched to reduce water shortage in *** study the most recent ground deformation,19 L-band ALOs-1 PALsAR images(June 2007–January 2011),24 C-band sentinel-1 sAR images(June 2015–November 2016)together with 9 ALOs-2 PALsAR acquisitions(september 2014–February 2017)were analysed in this *** measurements were exploited to verify the ALOs-1-based time series InsAR(Ts-InsAR)result while sentinel-1 and ALOs-2 result were cross-verified with each ***,the whole study area was divided into four sub-zones,and the result indicated that the subsidence rates over five townships,Cuigezhuan,Jinzhan,Liyuan,songzhuang and Yanjiao were accelerating and more attentions should be *** the contrary,the town centre of Douge Zhuang township experienced a decreasing trend between these two ***,the time series measurements with respect to five selected measurement points and the profile line along the subsidence hot spots were analysed.

关键词： subsidence Beijing groundwater sAR interferometry