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Effect of speed hump characteristics on pavement condition

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第1期4卷 103-110页

作者： Talaat ali abdel-Wahed Ibrahim Hassan Hashim Department of Civil Engineering Faculty of EngineeringSohag University Department of Civil Engineering Faculty of EngineeringMenoufia University

Speed humps are the most common type of traffic calming devices due to their low cost and easy installation. However, in many Egyptian roads, considerable number of these humps is randomly placed without proper engineering studies and justifications. Deteri- oration of pavement condition is observed near these humps. This paper presents a case study applied to collect and analyze visual inspection data for the reason of evaluating the impact of speed humps on pavement condition on intercity rural roads. The paper used 52 speed humps located in an intercity two-lane, two-way road that connects two cities, Tahta and Gerga, in Upper Egypt. The total length of this road is about 34 km. Pavement condition index （PCI）, in road sections, near speed humps in the two directions of travel were calculated from the visual inspection measurements. The characteristics of each speed hump （width, height, and distance from preceding hump） were measured. Using statistical analyses, the correlations between the pavement conditions and hump char- acteristics were examined. Regression analysis models were developed to represent the relationships between pavement conditions and hump characteristics. Generally, the re- sults proved that the pavement conditions are greatly influenced by the presence of speed humps and hump characteristics.

关键词： Speed hump Pavement condition Pavement condition index (PCI)Two-lane road Regression analysis

Evaluation of extracts and essential oil from Callistemon viminalis leaves:Antibacterial and antioxidant activities,total phenolic and flavonoid contents

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Asian Pacific Journal of Tropical Medicine 2013年第10期6卷 785-791页

作者： Mohamed ZM Salem Hayssam M ali Nader A El-Shanhorey Ahmed abdel-Megeed Forestry and Wood Technology Department Faculty of Agriculture(EL-Shatby)Alexandria University Botany and Microbiology Department College of ScienceKing Saud University Timber Trees Research Department Sabahia Horticulture Research StationHorticulture Research InstituteAgriculture Research Center Department of Botanical Gardens Research Horticultural Research Institute(ARC) Faculty of Agriculture(Saba Basha) Alexandria University

Objective:To investigate antioxidant and antibacterial activities of Callistemon viminalis(***)***:The essential oil of *** leaves obtained by hydrodistillation was analyzed by GC/*** extracts were tested for total phenolic and flavonoid contents and in vitro antioxidant(DPPH assay)and antibacterial(agar disc diffusion and 96-well micro-plates methods)***:Fourteen components were identified in the essential oil,representing 98.94%of the total *** major components were 1,8-cineole(64.53%)andα-pinene(9.69%).Leaf essential oil exhibited the highest antioxidant activity of(88.60±1.51)%comparable to gallic acid,a standard compound[(80.00±2.12)%].Additionally,the biggest zone of inhibitions against the studied bacterial strains was observed by the essential oil when compared to the standard antibiotic(tetracycline).The crude methanol extract and ethyl acetate fraction had a significant antibacterial activity against the tested bacterial ***:It can be suggested that *** is a great potential source of antibacterial and antioxidant compounds useful for new antimicrobial drugs from the natural *** present study revealed that the essential oil as well as the methanol extracts and ethyl acetate fraction of *** leaves exhibited highly significant antibacterial activity against the tested bacterial strains.

关键词： Callistemon viminalis Essential oil Antibacterial activity Antioxidant activity Phenolic content Flavonoid content

Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein Abou Zeid Mohamed ali Farag Manal abdel Aziz Hamed Zeinab abdel Aziz Kandil Radwa Hassan El-Akad Hanaa Mohamed El-Rafie Pharmacognosy Department National Research Centre Pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Engendered nanoparticles for treatment of brain tumors

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Oncology Research 2025年第1期33卷 15-26页

作者： SOROUSH SOLEYMANI MOHAMMAD DOROUDIAN MAHDIEH SOEZI ali BELADI KIARASH ASGARI ASO MOBARAKSHAHI ARYANA AGHAEIPOUR RONAN MACLOUGHLIN Department of Cell and Molecular Biology School of Biological SciencesUniversity of LeicesterLeicesterLE17RHUK Department of Cell and Molecular Biology Faculty of Biological SciencesKharazmi UniversityTehran15719-14911Iran Cancer Epidemiology Research Center Aja University of Medical SciencesTehran14117-18541Iran Medical Biotechnology Research Center Aja University of Medical SciencesTehran14117-18541Iran Department of Life Sciences Faculty of Natural SciencesImperial College LondonLondonSW72AZUK School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland(RCSI)DublinD02 YN77Ireland Research and Development Science and Emerging TechnologiesAerogen Ltd.Galway Business ParkGalwayH91 HE94Ireland School of Pharmacy and Pharmaceutical Sciences Trinity CollegeDublinD02 PN40Ireland

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain *** median survival time is typically less than a year after *** of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous *** blood-brain barrier is cooperating with advanced stages of *** blood-brain barrier poses a significant challenge to delivering systemic medications to brain *** delivery systems have emerged as promising tools for effectively crossing this ***,the development of smart nanoparticles brings new hope for cancer diagnosis and *** nanoparticles improve drug delivery efficiency,allowing for the creation of targeted and stimuli-responsive delivery *** review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment,exploring the range of nanoparticles under development,their applications,targeting strategies,and the latest progress in enhancing transport across the blood-brain *** also addresses the ongoing challenges and potential benefits of these innovative approaches.

关键词： Nanoparticles Smart nanoparticles Stimuli responsive nanoparticles Targeted nanoparticles Blood-brain barrier(BBB) Brain cancer

Spectral Analysis of Solar Variability and their Possible Role on the Global Warming

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Journal of Environmental Protection 2010年第2期1卷 111-116页

作者： Mohamed ali El-Borie Eman Shafik Aly abdel-moneim abdel-halim Shady Youssri El-Monier 不详

Our understanding of the indirect effect of changes in solar output and feedbacks in the climate system is minimal. There is much need to refine our understanding of key natural forcing mechanisms of the climate, including solar irra-diance changes, in order to reduce uncertainty in our projections of future climate change. Through the recent years, the conflict between researchers about whether global warming is a human-generated phenomenon or a result of solar variability has raised many question marks. The aim of this work is to try to answer some of these questions by studying the possible role of some solar variability parameters such as the geomagnetic index (aa) and the sunspot number (Rz) in global temperature changes. Here, we present a correlative study of the possible contributions for the two components that may be closely associated with the climate, throughout the last 130 years (1880-2008). We compared the correlation analysis and the power spectral density (PSD) of the Rz and aa with that of the continuous records of the GT in order to get a closer look at a possible connection between them. Our results displayed that the correlations between both (aa &GST) and (Rz &GST) are +0.66 and +0.38, respectively when both parameters Rz and aa precedes by 2-3 yrs. The correlation of GST-aa is two times higher than that of GST-Rz. The GST spectrum reflected significant periods at 21.3-yr, 10.7-11.6 yr variations that observed in the considered geomagnetic and sunspot spectra.

关键词： Global Rurface Temperature Geomagnetic Indices Solar Variability

Ferroptosis:mechanisms and links with diseases

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Signal Transduction and Targeted Therapy 2021年第3期6卷 648-663页

作者： Hong-fa Yan Ting Zou Qing-zhang Tuo Shuo Xu Hua Li abdel ali Belaidi Peng Lei Department of Neurology and State Key Laboratory of Biotherapy West China HospitalSichuan Universityand Collaborative Center for Biotherapy610041 ChengduChina West China School of Basic Medical Sciences and Forensic Medicine Sichuan University610041 ChengduChina Melbourne Dementia Research Centre and the Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVIC 3052Australia

Ferroptosis is an iron-dependent cell death,which is different from apoptosis,necrosis,autophagy,and other forms of cell *** process of feroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids,which can be prevented by iron chelators(***,deferoxamine)and small lipophilic antioxidants(e.g,ferrostatin,liproxstatin).This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association withseveral pathways,including iron,lipid,and cysteine *** have further discussed the contribution of ferroptosis to thepathogenesis of several diseases such as cancer,ischemia/reperfusion,and various neurodegenerative diseases(*** and Parkinson's disease),and evaluated the therapeutic applications of ferroptosis inhibitors in clinics.

关键词： diseases peroxidation death

Antimicrobial activity of whey milk and their fractions against Staphylococcus pasteuri clinical strain

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Food Bioscience 2023年第3期53卷 2440-2449页

作者： Sabry Y.M.Mahmoud Mohamed F.Ghaly Saadia M.H.Essa Seham abdel-Shafi Al-Shaymaa abdel-Monaem ali Osman Mohammed Aljeldah Basim Al Shammari Mahmoud E.F.abdel-Haliem Biology Department College of SciencesUniversity of Hafr Al BatinP.O.Box 1803Hafar Al Batin31991Saudi Arabia Botany and Microbiology Department Faculty of ScienceZagazig University45199ZagazigEgypt Microbiology Department Faculty of ScienceAin-Shams University11517AbbasiaEgypt Biochemistry Department Faculty of AgricultureZagazig University44511ZagazigEgypt Clinical Laboratory Sciences Department College of Applied Medical ScienceUniversity of Hafr Al-BatinP.O.Box 1803Hafar Al Batin31991Saudi Arabia

The antibacterial activity of Whey Milk and its fractions were studied against one hundred bacteria strains isolated and screened from various patients at the University Hospital of Zagazig,Sharkia Province,Egypt.F2 fraction of Whey Milk has shown the highest degree of antibacterial activity against the pathogenic bacteria A63 isolated from the *** whey(BW)was hydrolyzed with papain followed by fractionation using size exclusion chromatography(SEC).The fractionation profile of BWH showed three major peaks in Size exclusion chromatography,SECF1,SECF2,and SECF3 after 3h.F2 is the most active fraction and has faster migration than HP,F1,and F3 and may have higher positive charges on Urea-PAGE towards the cathode *** spectrum analysis of the F2 fraction of whey protein demonstrates the occurrence of distinctive functional groups,such as Alkanes,alcohols,phenols,flavonoids,alkenes,anhydrides,and halo *** biochemical characters and the 1.5 Kb 16S RNA gene’s nucleotide sequence of the most potent stain showed 99%similarity with Staphylococcus *** results showed that the ability of nanoparticles of whey to inhibit pathogenic bacteria decreases compared to raw whey and its *** deformation and partial and total lysis of cell components were seen in Staphylococcus pasteuri treated with whey F2 fraction under Transmission Electron Microscopy(TEM).

关键词： Whey protein Staphylococcus pasteuri Nanoparticles

Clinicopathological features and surgical outcome of patients with fibrolamellar hepatocellular carcinoma(experience with 22 patients over a 15-year period)

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World Journal of Gastrointestinal Surgery 2017年第2期9卷 61-67页

作者： Mohamed abdel Wahab Ehab El Hanafy Ayman El Nakeeb Mahmoud abdelwahab ali Gastroenterology Surgical Center Mansoura UniversityMansoura 35516Egypt

AIM To evaluate the clinicopathological features and the surgical outcomes of patients with fibrolamellar hepato-cellular carcinoma(FL-HCC)over a 15-year period. METHODS This is a retrospective study including 22 patients with a pathologic diagnosis of FL-HCC who underwent hepatectomy over a 15-year period. Tumor characteristics,survival and recurrence were evaluated. RESULTS There were 11 male and 11 female with a median age of 29 years(range from 21 to 58 years). Two(9%)patients had hepatitis C viral infection and only 2(9%)patients had alpha-fetoprotein level > 200 ng/m L. The median size of the tumors was 12 cm(range from 5-20 cm). Vascular invasion was detected in 5(23%)patients. Four(18%)patients had lymph node metastases. The median follow up period was 42 mo and the 5-year survival was 65%. Five(23%)patients had a recurrent disease,4 of them had a second surgery with 36 mo median time interval. Vascular invasion is the only significant negative prognostic factor CONCLUSION FL-HCC has a favorable prognosis than common HCC and should be suspected in young patients with non cirrhotic liver. Aggressive surgical resection should be done for all patients. Repeated hepatectomy should be considered for these patients as it has a relatively indolent course.

关键词： Fibrolamellar hepatocellular carcinoma Common hepatocellular carcinoma Recurrence after resection fibrolamellar hepatocellular carcinoma Pathology of fibrolamellar hepatocellular carcinoma Survivalefter resection fibrolamellar hepatocellular carcinoma