Engendered nanoparticles for treatment of brain tumors
作者机构：Department of Cell and Molecular Biology School of Biological Sciences University of Leicester Leicester LE1 7RH UK. Department of Cell and Molecular Biology Faculty of Biological Sciences Kharazmi University Tehran 15719-14911 Iran. Cancer Epidemiology Research Center Aja University of Medical Sciences Tehran 14117-18541 Iran. Medical Biotechnology Research Center Aja University of Medical Sciences Tehran 14117-18541 Iran. Department of Life Sciences Faculty of Natural Sciences Imperial College London London SW7 2AZ UK. School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland (RCSI) Dublin D02 YN77 Ireland. Research and Development Science and Emerging Technologies Aerogen Ltd. Galway Business Park Galway H91 HE94 Ireland. School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin D02 PN40 Ireland.
出 版 物：《Oncology research》 (肿瘤学研究（英文）)
年 卷 期：2025年第33卷第1期
页 面：15-26页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Blood-brain barrier (BBB) Brain cancer Nanoparticles Smart nanoparticles Stimuli responsive nanoparticles Targeted nanoparticles
摘 要：Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system. The blood-brain barrier is cooperating with advanced stages of malignancy. The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors. Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier. Additionally, the development of smart nanoparticles brings new hope for cancer diagnosis and treatment. These nanoparticles improve drug delivery efficiency, allowing for the creation of targeted and stimuli-responsive delivery methods. This review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment, exploring the range of nanoparticles under development, their applications, targeting strategies, and the latest progress in enhancing transport across the blood-brain barrier. It also addresses the ongoing challenges and potential benefits of these innovative approaches.
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