Ferroptosis:mechanisms and links with diseases
作者机构：Department of Neurology and State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Center for Biotherapy610041 ChengduChina West China School of Basic Medical Sciences and Forensic MedicineSichuan University610041 ChengduChina Melbourne Dementia Research Centre and the Florey Institute of Neuroscience and Mental HealthThe University of MelbourneParkvilleVIC 3052Australia
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第3期
页 面：648-663页
核心收录：
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
基 金：Supported by funds from the Ministry of Science and Technology of China(2018YFC1312300) The National Natural Science Foundation of China(81722016,82071191) The Alzheimer’s Association(AARFD-16-442821)
主 题：diseases peroxidation death
摘 要：Ferroptosis is an iron-dependent cell death,which is different from apoptosis,necrosis,autophagy,and other forms of cell *** process of feroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids,which can be prevented by iron chelators(***,deferoxamine)and small lipophilic antioxidants(e.g,ferrostatin,liproxstatin).This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association withseveral pathways,including iron,lipid,and cysteine *** have further discussed the contribution of ferroptosis to thepathogenesis of several diseases such as cancer,ischemia/reperfusion,and various neurodegenerative diseases(*** and Parkinson s disease),and evaluated the therapeutic applications of ferroptosis inhibitors in clinics.
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