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Assistive Robotics for Upper Limb Physical Rehabilitation:A Systematic Review and Future Prospects

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 50-73页

作者： Andrés Guatibonza Leonardo Solaque alexandra Velasco Lina Peñuela Department of Engineering Mechatronics EngineeringMilitar Nueva Granada UniversityBogotá1101111Colombia

Physical assistive robotics are oriented to support and improve functional capacities of *** physical rehabilitation,robots are indeed useful for functional recovery of affected ***,there are still open questions related to technological *** work presents a systematic review of upper limb rehabilitation robotics in order to analyze and establish technological challenges and future directions in this area.A bibliometric analysis was performed for the systematic literature *** from the last six years,conducted between August 2020 and May 2021,was *** methodology for the literature search and a bibliometric analysis of the metadata are *** a preliminary search resulted in 820 articles,a total of 66 articles were included.A concurrency network and bibliographic analysis were *** an analysis of occurrences,taxonomy,and rehabilitation robotics reported in the literature is *** review aims to provide to the scientific community an overview of the state of the art in assistive robotics for upper limb physical *** literature analysis allows access to a gap of unexplored options to define the technological prospects applied to upper limb physical rehabilitation robotics.

关键词： Upper limb Rehabilitation Assistive robotics Human-machine interaction Robotic systems Virtual reality Rehabilitation monitoring

DNA plasticity and damage in amyotrophic lateral sclerosis

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Neural Regeneration Research 2018年第2期13卷 173-180页

作者： Diane Penndorf Otto W.Witte alexandra Kretz Hans Berger Department of Neurology University Hospital Jena

The pathophysiology of amyotrophic lateral sclerosis （ALS） is particularly challenging due to the heteroge- neity of its clinical presentation and the diversity of cellular, molecular and genetic peculiarities involved. Molecular insights unveiled several novel genetic factors to be inherent in both familial and sporadic dis- ease entities, whose characterizations in terms of phenotype prediction, pathophysiological impact and putative prognostic value are a topic of current researches. However, apart from genetically well-defined high-confidence and other susceptibility loci, the role of DNA damage and repair strategies of the genome as a whole, either elicited as a direct consequence of the underlying genetic mutation or seen as an autono- mous parameter, in the initiation and progression of ALS, and the different cues involved in either process are still incompletely understood. This mini review summarizes current knowledge on DNA alterations and counteracting DNA repair strategies in ALS pathology and discusses the putative role of unconventional DNA entities including transposable elements and extrachromosomal circular DNA in the disease process. Focus is set on SODl-related pathophysiology, with extension to FUS, TDP-43 and C90RF72 mutations. Advancing our knowledge in the field will contribute to an improved understanding of this relentless dis- ease, for which therapeutic options others than symptomatic approaches are almost unavailable.

关键词： amyotrophic lateral sclerosis DNA damage and repair extrachromosomal circular DNA microDNA nuclear pore complex SOD1 mutations TDP-43 pathology transposable elements

Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

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Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： alexandra Chovsepian Laura Empl Florence M.Bareyre Institute of Clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability *** creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

Optical neuroimaging of executive function impairments in food addiction

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 141-155页

作者： Tania alexandra Couto Meng-Yun Wang Zhen Yuan Centre for Cognitive and Brain Sciences University of Macao TaipaMacao SARP.R.China Faculty of Health SciencesUniversity of MacaoTaipaMacao SARP.R.China

This study investigated the neural mechanisms located in the prefrontal cortex(PFC)involved in maintaining addictive-like eating ***,we aimed toll a gap in the existing literature and help clarify the food addiction(FA)cycle by inspecting the relationship between the executive control and psychopathology involved in the FA ***-three students recruited from the University of Macao participated in this *** investigated a hemodynamic response captured by NIRS recordings,activated during n-back,set-shifting,and go/nogo ***,we investigated the FA symptoms through the YFAS clinical inventory to better understand the relationship between hemodynamic response and clinical symptomatology in college ***,the hemodynamicndings conrm that altered cognitive control in executive function performance appears to be linked to addictive-like eating behaviors,which in turn conrms a circuit similarity between FA and the substance abuse population(SUD)as reported in previous fMRI ***,the psychologicalndings conrm the signicant association between the working memory decits and symptoms severity which suggest the role of self-control and regulation in limiting the storage resources as a potential trigger to develop overconsumption episodes in the FA *** highlight how disrupted self-control and regulation of craving and negative a®ect induced by mental imagery might shape and overload the working memory storage as a potential trigger to develop binge eating episodes to maintain the FA *** conclusion,the use of fNIRS in the context of eating disorders studies represents a valuable application,noninvasive,and patientfriendly tool,providing new insights into understanding the addiction cycle and treatment guidelines.

关键词： Food addiction executive functions working memory self-control optical neuroimaging.

Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

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Chinese Journal of Chemical Engineering 2016年第4期24卷 513-520页

作者： Anca-Irina Galaction Dan Cascaval Ramona-Mihaela Matran alexandra Tucaliuc "Grigore T. Popa" University of Medicine and Pharmacy of Iasi Faculty of Medical Bioengineering Dept. of Biomedical Science M. Kogalniceanu 9-13 700454 Iasi Romania "Gheorghe Asachi" Technical University of Iasi Faculty of Chemical Engineering and Environmental Protection. Dept. of Biochemical Engineering D. Mangeron 73 700050 Iasi Romania

The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor with mobile bed is more efficient for biocatalyst particles with a diameter over 3 mm, while the basket bioreactor is more efficient for smaller biocatalyst particles and basket bed thickness below 5 mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.

关键词： Mass transferDiffusionStirred vesselImmobilized cellsBasket bioreactorSuccinic acid

Metabolic Control of Chloroplast Gene Expression： An Emerging Theme

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Molecular Plant 2017年第1期10卷 1-3页

作者： alexandra-Viola Bohne J?rg Nickelsen Department Biology I Molecular Plant Sciences LMU Munich Grosshaderner Strasse 2-4 82152 Planegg-Martinsried Germany

In all organisms, regulation of gene expression plays an essential part in acclimation to changes in the environment and the meta-bolic status of cells. However, little is known about the mecha-nisms by which nutritio... 详细信息

关键词： Control Expression Theme

Vaccine breakthrough and rebound infections modeling:Analysis for the United States and the ten *** regions

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Infectious Disease Modelling 2023年第3期8卷 717-741页

作者： Olusegun Michael Otunuga alexandra Yu Department of Mathematics Augusta University112015th StrGE 2018AugustaGA30912USA

A vaccine breakthrough infection and a rebound infection cases of COVID-19 are studied and analyzed for the ten *** of Health and Human Services(HHS)regions and the United States as a nation in this *** innovative multi-strain susceptible-vacci-nated-exposed-asymptomatic-symptomatic-recovered(SVEAIR)epidemic model is devel-oped for this purpose for a population assumed to be susceptible to n-different variants of the disease,and those who are vaccinated and recovered from a specific strain k(kn)of the disease are immune to present strain and its predecessors j=1,2,…,k,but can still be infected by newer emerging strains j=k+1,k+2,…,*** model is used to estimate epidemiological parameters,namely,the latent and infectious periods,the transmission rates,vaccination rates,recovery rates for each of the Delta B.1.617.2,Omicron B.1.1.529,and lineages BA.2,BA.2.12.1,BA.4,BA.5,BA.1.1,BA.4.6,and BA.5.2.6 for the United States and for each of the ten HHS *** transmission rate is estimated for both the asymptomatic and symptomatic *** effect of vaccines on each strain is *** that guarantees existence of an endemic with certain number of strains is derived and used to describe the endemic state of the population.

关键词： Multi-strain Delta Omicron Lineages Vaccine breakthrough Rebound infection

Role of practice standardization in outcome optimization for CDH

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World Journal of Pediatric Surgery 2024年第2期7卷 110-118页

作者： alexandra Dimmer Robert Baird Pramod Puligandla Harvey E.Beardmore Division of Pediatric Surgery Department of Pediatric SurgeryMontreal Children's HospitalMontrealQuebecCanada Division of Pediatric General and Thoracic Surgery British Columbia Children's HospitalVancouverBritish ColumbiaCanada Harvey E.Beardmore Department of Pediatric Surgery McGill UniversityMontrealQuebecCanada

Standardization of care seeks to improve patient outcomes and healthcare delivery by reducing unwanted variations in care as well as promoting the efficient and effective use of healthcare *** are many types of standardization,with clinical practice guidelines(CPGs),based on a stringent assessment of evidence and expert consensus,being the hallmark of high-quality *** article outlines the history of CPGs,their benefits and shortcomings,with a specific focus on standardization efforts as it relates to congenital diaphragmatic hernia management.

关键词： congenital clinical shortcomings

Effect of niobium alloying level on the oxidation behavior of titanium aluminides at 850°C

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International Journal of Minerals,Metallurgy and Materials 2016年第12期23卷 1452-1457页

作者： alexandra Banu Maria Marcu Simona Petrescu Nicolae Ionescu Alexandru Paraschiv Faculty of Engineering and Management of Technological Systems Politehnica University of BucharestSplalul Independentei 313060032Bucharest060042Romania Department of Electrochemistry and Corrosion Institute of Physical Chemistry'Ilie Murgulescu'Splaiul Independentei 202Bucharest060021Romania Department of Gas Turbines Special Components COMOTI-R&D Romanian InstituteBd Iuliu Maniu 220061126BucharestRomania

This work addresses the alloying of titanium aluminides used in aircraft engine applications and automobiles. The oxidation resistance behavior of two titanium aluminides of α2 ＋ γ （Ti3Al ＋ TiAl） and orthorhombic Ti2NbAl, recognized as candidates for high-temperature applications, was investigated by exposure of the alloys for 100 h in air. Thus, oxidation resistance was expressed as the mass gain rate, whereas surface aspects were analyzed using scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy, and the type of oxidation products was analyzed by X-ray diffraction and Raman spectroscopy. The orthorhombic Ti2NbAl alloy was embrittled, and pores and microcracks were formed as a result of oxygen diffusion through the external oxide layer formed during thermal oxidation for 100 h.

关键词： titanium aluminide thermal oxidation oxidation resistance niobium alloying