Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

作     者：Anca-Irina Galaction Dan Cascaval Ramona-Mihaela Matran Alexandra Tucaliuc 

作者机构："Grigore T. Popa" University of Medicine and Pharmacy of Iasi Faculty of Medical Bioengineering Dept. of Biomedical Science M. Kogalniceanu 9-13 700454 Iasi Romania "Gheorghe Asachi" Technical University of Iasi Faculty of Chemical Engineering and Environmental Protection. Dept. of Biochemical Engineering D. Mangeron 73 700050 Iasi Romania 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2016年第24卷第4期

页      面：513-520页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 081703[工学-生物化工] 0817[工学-化学工程与技术] 08[工学] 0703[理学-化学] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：Supported by the Grant PN-II-PT-PCCA-2011-3.1-1268 authorized by The National Council for Scientific Research-Executive Unit for Financing Higher Education Research Development and Innovation(CNCS-UEFISCDI) 

主　　题：填充床生物反应器 琥珀酸 移动床 传质 基质 生产 生物催化剂 生物合成 

摘      要：The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor with mobile bed is more efficient for biocatalyst particles with a diameter over 3 mm, while the basket bioreactor is more efficient for smaller biocatalyst particles and basket bed thickness below 5 mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.