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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

Neuroscience Bulletin 2018年第2期34卷 270-282页

作者： Maria Antonietta Panaro alessandra Aloisi Giuseppe Nicolardi Dario Domenico Lofrumento Francesco de Nuccio Velia La Pesa Antonia Cianciulli rosaria Rinaldi rosa Calvello Vania Fontani Salvatore Rinaldi department of Biosciences Biotechnologies and Biophar- maceutics University of Bari Bari Italy CNR Institute for Microelectronics and Microsystems Via Monteroni (Campus Ecotekne) 73100 Lecce Italy department of Biological and Environmental Sciences and Technologies Section of Human Anatomy University of Salento Lecce Italy Neuropathology Unit Institute of Experimental Neurology Division of Neuroscience IRCCS San Raffaele Scientific Institute Via Olgettina 60 20132 Milan Italy department of Mathematics and Physics University of Salento Via Amesano 73100 Lecce Italy CNR Institute of Nanoscience NEST Piazza San Silvestro 12 56127 Pisa Italy department of Regenerative Medicine Rinaldi Fontani Institute Viale Belfiore 43 50144 Florence Italy Research department Rinaldi Fontani Foundation Viale Belfiore 43 50144 Florence Italy IRF (Shanghai) Medical Sciences 3000 Long Dong Avenue Zhangjiang High-Tech Park Shanghai China

In this study, the effects of Radio Electric Asymmetric Conveyer(REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes(REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage inmice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TORGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.

关键词： Parkinson’s disease Neurodegeneration Neuroinflammation REAC TO-RGN-N treatment

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Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity

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Neural Regeneration Research 2022年第10期17卷 2223-2224页

作者： Suellen alessandra Soares de Moraes Faculdade de Fisioterapia e Terapia Ocupacional Universidade Federal do ParáBelémParáBrazil

Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon rupture.They involve inflammation and lead to loss of motion.In chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical loading.This term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020).

关键词： tendon injuries Acute

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Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR):A critical overview on the most promising applications of molecular scissors in oral medicine

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BIOCELL 2022年第8期46卷 1837-1842页

作者： MARCO TATULLO LUISA LIMONGELLI rosa MARIA MARANO alessandra VALLETTA ANGELA TEMPESTA SANDRO RENGO department of Basic Medical Sciences Neurosciences and Sense OrgansUniversity of Bari Aldo MoroBari74124Italy department of Interdisciplinary Medicine University of Bari Aldo MoroBari74124Italy Marrelli Health-Tecnologica Research Institute Biomedical SectionStem Cells and Medical Genetics UnitsCrotone88900Italy department of Neurosciences Reproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples80131Italy

The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments.CRISPR-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly known as the“molecular scissor”,represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments,related to several human diseases,such as chronic diseases,neurodegenerative pathologies and,interestingly,oral diseases.Of course,dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches:in this landscape,the use of CRISPR-Cas9 system may speed and personalize the traditional therapies,ensuring a good predictability of clinical results.The aim of this critical overview is to provide evidence on CRISPR efficacy,taking into specific account its applications in oral medicine.

关键词： Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR) dentistry Stem cells

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Spatiotemporal variations of ozone exposure and its risks to vegetation and human health in Cyprus:an analysis across a gradient of altitudes

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Journal of Forestry Research 2023年第3期34卷 579-594页

作者： Stefanos Agathokleous Costas JSaitanis Chrysanthos Savvides Pierre Sicard Evgenios Agathokleous alessandra de Marco The Cyprus Institute NicosiaCyprus University of the Aegean MytileneLesvosGreece Agricultural University of Athens AthensGreece department of Labour Inspection Ministry of Labour and Social InsuranceNicosiaCyprus ARGANS 260 route du Pin MontardBiotFrance School of Applied Meteorology Nanjing University of Information Science and Technology(NUIST)Nanjing 210044People’s Republic of China National Agency for New Technologies Energy and Sustainable Economic DevelopmentRomeItaly

Ground-level ozone(O_(3)) aff ects vegetation and threatens environmental health when levels exceed critical values,above which adverse eff ects are expected.Cyprus is expected to be a hotspot for O_(3)concentrations due to its unique position in the eastern Mediterranean,receiving air masses from Europe,African,and Asian continents,and experiencing a warm Mediterranean climate.In Cyprus,the spatiotemporal features of O_(3) are poorly understood and the potential risks for forest health have not been explored.We evaluated O_(3) and nitrogen oxides(NO and NO 2)at four regional background stations at different altitudes over 2014−2016.O_(3) risks to vegetation and human health were estimated by calculating accumulated O_(3)exposure over a threshold of 40 nmol mol^(−1)(AOT40)and cumulative exposure to mixing ratios above 35 nmol mol^(−1)(SOMO35)indices.The data reveal that mean O_(3)concentrations follow a seasonal pattern,with higher levels in spring(51.8 nmol mol^(−1))and summer(53.2 nmol mol^(−1))and lower levels in autumn(46.9 nmol mol^(−1))and winter(43.3 nmol mol^(−1)).The highest mean O_(3)exposure(59.5 nmol mol^(−1)) in summer occurred at the high elevation station Mt.Troodos(1819 m a.s.l.).Increasing(decreasing)altitudinal gradients were found for O_(3)(NO x),driven by summer–winter diff erences.The diurnal patterns of O_(3) showed little variation.Only at the lowest altitude O_(3) displayed a typical O_(3) diurnal pattern,with hourly diff erences smaller than 15 nmol mol^(−1).Accumulated O_(3) exposures at all stations and in all years exceeded the European Union’s limits for the protection of vegetation,with average values of 3-month(limit:3000 nmol mol^(−1)h)and 6-month(limit:5000 nmol mol^(−1)h)AOT40 for crops and forests of 16,564 and 31,836 nmol mol^(−1)h,respectively.O_(3) exposures were considerably high for human health,with an average SOMO35 value of 7270 nmol mol^(−1) days across stations and years.The results indicate that O_(3) is a major environmental and public health issue in Cyprus,and poli

关键词： Air pollution Ozone risk assessment Exposure metrics Vegetation Human health

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Feeding broiler chickens with arginine above recommended levels:effects on growth performance,metabolism,and intestinal microbiota

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1528-1541页

作者： Giorgio Brugaletta Marco Zampiga Luca Laghi Valentina Indio Chiara Oliveri alessandra de Cesare Federico Sirri department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly department of Veterinary Medical Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly department of Physics and Astronomy Alma Mater Studiorum-University of Bologna40127 BolognaItaly

Background Arginine is an essential amino acid for chickens and feeding diets with arginine beyond the recommended levels has been shown to influence the growth performance of broiler chickens in a positive way.Nonetheless,further research is required to understand how arginine supplementation above the widely adopted dosages affects metabolism and intestinal health of broilers.Therefore,this study was designed to assess the effects of arginine supplementation(i.e.,total arginine to total lysine ratio of 1.20 instead of 1.06-1.08 recommended by the breeding company) on growth performance of broiler chickens and to explore its impacts on the hepatic and blood metabolic profiles,as well as on the intestinal microbiota.For this purpose,630 one-day-old male Ross 308 broiler chicks were assigned to 2 treatments(7 replicates each) fed a control diet or a crystalline L-arginine-supplemented diet for 49 d.Results Compared to control birds,those supplemented with arginine performed significantly better exhibiting greater final body weight at D49(3778 vs.3937 g;P detes and Lactobacillus salivarius were found in the caecal content of supplemented birds.Conclusions The improvement in growth performance corroborates the advantages of supplementing arginine in broiler nutrition.It can be hypothesized that the performance enhancement found in this study is associated with the increased availability of arginine,betaine,histid

关键词： Arginine Broiler chicken Growth performance Metabolism Microbiota

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Pseudo-discontinuum model to simulate hard-rock mine pillars

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Underground Space 2023年第4期11卷 81-95页

作者： Erick Ro genes alessandra dos Santos Gomes Marcio Muniz de Farias Leandro Lima Rasmussen Faculty of Technology University of BrasiliaDF 70910-900BrasiliaBrazil

In this study,the pseudo-discontinuum modeling technique,called continuum Voronoi block model(CVBM),was applied to repre-sent the behavior of hard-rock pillars from underground mines subjected to high field stresses.The CVBM’s ability to produce numerical results consistent with the observed behavior of pillars is demonstrated through the numerical analysis of a hypothetical case and a back analysis of the Creighton mine pillar.The results show that the model can capture convergence displacements and explicitly show the formation of macro-fractures parallel to excavation walls,intact rock slabs,and V-shaped notches.These components are characteristics of brittle failure induced by highly stressed ground conditions.The studies presented in this work confirm the CVBM as a convenient tool for the numerical modeling of intact rock pillars excavated in deep underground mines.

关键词： Brittle failure Spalling Bulking Voronoi tessellation

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A multi-agent system for itinerary suggestion in smart environments

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CAAI Transactions on Intelligence Technology 2021年第4期6卷 377-393页

作者： alessandra de Paola Salvatore Gaglio Andrea Giammanco Giuseppe Lo Re Marco Morana Universita degzi studi di Palermo PalermoItaly Srart Cities and Comtnunitics Natioral Jab CINI-Consorzio Interuniversitario Nazionale per l'Infortnatica PalerinoItaly

Modem smart environments pose several challenges,among which the design of intelligent algorithms aimed to assist the users.When a variety of points of interest are available,for instance,trajectory recommendations are needed to suggest users the most suitable itineraries based on their interests and contextual constraints.Unfortunately in many cases,these interests must be explicitly requested and their lack causes the so-called cold-start problem.Moreover,lengthy travelling distances and excessive crowdedness of specific points of interest make itinerary planning more difficult.To address these aspects,a multi-agent itinerary suggestion system that aims at assisting the users in an online and collaborative way is proposed.A profiling agent is responsible for the detection of groups of users whose movements are characterised by similar semantic,spatial and temporal features;then,a recommendation agent leverages contextual information and dynamically associates the current user with the trajectory clusters according to a Multi-Armed Bandit policy;Framing the trajectory recommendation as a reinforcement learning problem permits to provide high-quality suggestions while avoiding both cold-start and preference elicitation issues.The effectiveness of the approach is demonstrated by some deployments in real-life scenarios,such as smart campuses and theme parks.

关键词： artificial intelligence pattern recognition

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Competences for self-care and self-control in diabetes mellitus type 2 in primary health care

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World Journal of Diabetes 2019年第8期10卷 454-462页

作者： Maria Marta Amancio Amorim alessandra Hugo de Souza Adriana Keller Coelho Centro de Estudos Em Migracoes E Relacoes Interculturais Belo Horizonte 302240010Brazil Programa de Pos graduacao em Biologia de Vertebrados Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535901Brazil Geriatric Unit Hospital do Instituto de Previdência dos Servidores do Estado de Minas GeraisBelo Horizonte 3010110Brazil

The purpose of the guidelines of self-care and self-control of type 2 diabetes mellitus proposed by the Brazilian Ministry of Health is to strengthen and qualify users and health care professionals through the integrality and longitudinality of care with this disease.This article aims to present the self-care and self-control of people with type 2 diabetes mellitus in objective terms,taking into account the current recommen-dations based on scientific evidence and also from the subjective point of view,that is,emphasizing the aspects related to experience and subjectivity of these people.Next,we present the essential skills for self-care and self-control of users and professionals working in primary health care.

关键词： Diabetes mellitus type 2 Self-care Primary health care

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Hepatitis C virus micro-elimination:Where do we stand?

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World Journal of Gastroenterology 2021年第16期27卷 1728-1737页

作者： alessandra Mangia rosa Cotugno Giovanna Cocomazzi Maria Maddalena Squillante Valeria Piazzolla Liver Unit Department of Medical SciencesIRCCS Casa Sollievo della SofferenzaSan Giovanni Rotondo 71013FgItaly

Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviraltreatments, has been promoted by the World Health Organization. Thisachievement is not attainable, however, particularly after the 2020 pandemic ofthe coronavirus disease 2019. Consequently, the more realistic objective ofeliminating HCV from population segments for which targeted strategies ofprevention and treatment are easily attained has been promoted in Europe, as avalid alternative. The underlying idea is that micro-elimination will ultimatelylead to macro-elimination. The micro-elimination strategy may target differentspecific populations and at-risk groups. Different settings, including prisons andhospitals, have also been identified as micro-elimination scenarios. In addition,dedicated micro-elimination strategies have been designed that are tailored at thegeographical level according to HCV epidemiology and individual country’sincome. The main elements of a valid and successful micro-elimination project arereliable epidemiological data and active involvement of all the stakeholders.Community involvement represents another essential component for a successfulprogram.

关键词： Hepatitis C virus antibodies Hepatitis C virus elimination Hepatitis C virus epidemiology Hepatitis C virus RNA Hepatitis C virus diagnosis Hepatitis C virus infection

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α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

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Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： alessandra Bigi Roberta Cascella Cristina Cecchi department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system atrophy.In such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial cells.Growing expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein pathology.Moreover,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient neurons.In this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

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