Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

作     者：Maria Antonietta Panaro Alessandra Aloisi Giuseppe Nicolardi Dario Domenico Lofrumento Francesco De Nuccio Velia La Pesa Antonia Cianciulli Rosaria Rinaldi Rosa Calvello Vania Fontani Salvatore Rinaldi 

作者机构：Department of Biosciences Biotechnologies and Biophar- maceutics University of Bari Bari Italy CNR Institute for Microelectronics and Microsystems Via Monteroni (Campus Ecotekne) 73100 Lecce Italy Department of Biological and Environmental Sciences and Technologies Section of Human Anatomy University of Salento Lecce Italy Neuropathology Unit Institute of Experimental Neurology Division of Neuroscience IRCCS San Raffaele Scientific Institute Via Olgettina 60 20132 Milan Italy Department of Mathematics and Physics University of Salento Via Amesano 73100 Lecce Italy CNR Institute of Nanoscience NEST Piazza San Silvestro 12 56127 Pisa Italy Department of Regenerative Medicine Rinaldi Fontani Institute Viale Belfiore 43 50144 Florence Italy Research Department Rinaldi Fontani Foundation Viale Belfiore 43 50144 Florence Italy IRF (Shanghai) Medical Sciences 3000 Long Dong Avenue Zhangjiang High-Tech Park Shanghai China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2018年第34卷第2期

页      面：270-282页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a Fondazione Umberto Veronesi 2011 grant to RR a grant from the University of Bari(Fondi di Ateneo 2014) a grant from the University of Salento(Fondi di Ateneo 2014) 

主　　题：Parkinson’s disease Neurodegeneration Neuroinflammation REAC TO-RGN-N treatment 

摘      要：In this study, the effects of Radio Electric Asymmetric Conveyer(REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes(REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage inmice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TORGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.