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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Probing the Efficiency of PPMG-Based Composite Electrolytes for Applications of Proton Exchange Membrane Fuel Cell

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Transactions of Tianjin University 2024年第3期30卷 262-283页

作者： Shakeel Ahmed Faizah Altaf Safyan akram Khan Sumaira Manzoor Aziz Ahmad Muhammad Mansha Shahid Ali Ata-ur-Rehman Karl Jacob School of Material Science and Engineering Henan International Joint Laboratory of Nano-Photoelectric Magnetic MaterialsHenan University of TechnologyZhengzhou 450001China Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management King Fahd University of Petroleum and Minerals31261 DhahranSaudi Arabia School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

PPMG-based composite electrolytes were fabricated via the solution method using the polyvinyl alcohol and polyvinylpyrrolidone blend reinforced with various contents of sulfonated inorganic *** acid was employed as the sulfonating agent to functionalize the external surface of the inorganic filler,i.e.,graphene *** proton conductivities of the newly prepared proton exchange membranes(PEMs)were increased by increasing the temperature and content of sulfonated graphene oxide(SGO),i.e.,ranging from 0.025 S/cm to 0.060 S/*** induction of the optimum level of SGO is determined to be an excellent route to enhance ionic *** single-cell performance test was conducted by sandwiching the newly prepared PEMs between an anode(0.2 mg/cm^(2) Pt/Ru)and a cathode(0.2 mg/cm^(2) Pt)to prepare membrane electrode assemblies,followed by hot pressing under a pressure of approximately 100 kg/cm^(2) at 60℃for 5–10 *** highest power densities achieved with PPMG PEMs were 14.9 and 35.60 mW/cm^(2) at 25℃and 70℃,respectively,at ambient pressure with 100%relative *** showed that the newly prepared PEMs exhibit good electrochemical *** results indicated that the prepared composite membrane with 6 wt%filler can be used as an alternative membrane for applications of high-performance proton exchange membrane fuel cell.

关键词： Proton exchange membrane fuel cell Sulfonated graphene oxide Polyvinylpyrrolidone Solution casting Membrane electrode assembly Fuel cell performance

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Adult neurogenesis:a real hope or a delusion?

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Neural Regeneration Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain Rabia akram Haseeb Anwar Faiqa Sajid Tehreem Iman Hyung Soo Han Chand Raza Jose-Luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

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Mid-term outcomes of a kinematically designed cruciate retaining total knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 118-128页

作者： Jonathan L Katzman akram A Habibi Muhammad A Haider Casey Cardillo Ivan Fernandez-Madrid Morteza Meftah Ran Schwarzkopf Department of Orthopedic Surgery Division of Adult Reconstructive SurgeryNYU Langone Orthopedic HospitalNYU Langone HealthNew YorkNY 10010United States

BACKGROUND Advances in implant material and design have allowed for improvements in total knee arthroplasty(TKA)outcomes.A cruciate retaining(CR)TKA provides the least constraint of TKA designs by preserving the native posterior cruciate *** research exists that has examined clinical outcomes or patient reported outcome measures(PROMs)of a large cohort of patients undergoing a CR TKA utilizing a kinematically designed *** was hypothesized that the studied CR Knee System would demonstrate favorable outcomes and a clinically significant improvement in pain and functional *** To assess both short-term and mid-term clinical outcomes and PROMs of a novel CR TKA *** A retrospective,multi-surgeon study identified 255 knees undergoing a TKA utilizing a kinematically designed CR Knee System(JOURNEY™II CR;Smith and Nephew,Inc.,Memphis,TN)at an urban,academic medical institution between March 2015 and July 2021 with a minimum of two-years of clinical follow-up with an orthopedic *** demographics,surgical information,clinical outcomes,and PROMs data were collected via query of electronic medical *** PROMs collected in the present study included the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement(KOOS JR)and Patient-Reported Outcomes Measurement Information System(PROMIS■)*** significance of improvements in mean PROM scores from preoperative scores to scores collected at six months and two-years postoperatively was analyzed using Independent Samples *** Of the 255 patients,65.5%were female,43.8%were White,and patients had an average age of 60.6 *** osteoarthritis(96.9%)was the most common primary *** mean surgical time was 105.3 minutes and mean length of stay was 2.1 d with most patients discharged home(92.5%).There were 18 emergency department(ED)visits within 90 d of surgery resulting in a 90 d ED visit rate of 7.1%,including a 2.4%orthopedic-related ED visit ra

关键词： Total knee arthroplasty Cruciate retaining Kinematic design Survivorship Bearing material Prosthetic design Clinical outcomes Patient-reported outcome measures

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Assessing Spatio-Temporal Land Cover Changes in Dhund River Basin, Eastern Rajasthan (India), Using Multi-Temporal Landsat Data

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Journal of Geographic Information System 2024年第4期16卷 244-258页

作者： Sadia Mazahir akram Javed Mohd Yusuf Khanday Department of Geology Aligarh Muslim University Aligarh India Geological Survey of India Western Region Jaipur India

Land cover is an impression of natural cover on surface of earth such as bare soil, river, grass etc. and utilization of these natural covers for various human needs and purposes by mankind is defined as land use. Land cover identification, delineation and mapping is important for planning activities, resource management and global monitoring studies while baseline mapping and subsequent monitoring is done by application of land use to get timely information about quantity of land that has been used. The present study has been carried out in Dhund river watershed of Jaipur, Rajasthan which covers an area of about 1828 sq∙km. The minimum and maximum elevation of the area is found to be 214 m and 603 m respectively. Land use and land cover changes of three decades from 1991 to 2021 have been interpreted by using remotes sensing and GIS techniques. ArcGIS software (Arc map 10.2), SOI topographic map, Cartosat-1 DEM and satellite data of Landsat 5 and Landsat 8 have been used for interpretation of eleven classes. The study shows an increase in cultivated land, settlement, waterbody, open forest, plantation and mining due to urbanization because of increasing demands of food, shelter and water while a decrease in dense forest, river, open scrub, wasteland and uncultivated land has also been marked due to destruction of aforementioned by anthropogenic activities such as industrialization resulting in environmental degradation that leads to air, soil and water pollution.

关键词： Dhund River Landsat Land Use/Land Cover Change Detection Analysis Rajasthan

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Circulating levels of advanced glycation end products in females with polycystic ovary syndrome:a meta-analysis

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Reproductive and Developmental Medicine 2024年第2期8卷 93-100页

作者： Seyed Sobhan Bahreiny akram Ahangarpour Mojtaba Aghaei Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences Research Institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Polycystic ovary syndrome(PCOS)is a common endocrine disorder characterized by a hormonal imbalance that affects females of reproductive *** association between advanced glycation end products(AGEs)and PCOS has attracted considerable attention in recent years,highlighting the potential of AGEs as biomarkers for this *** the present systematic review and meta-analysis,we aimed to examine the association between AGEs and PCOS,evaluate their potential as biomarkers,and improve our understanding of the pathophysiology of PCOS and its associated metabolic complications.A literature search was performed using various databases from January 2000 to March 2023 to identify relevant studies investigating the association between AGEs and *** effect estimates were calculated using standardized mean differences(SMD)with 95%confidence intervals(CIs).Sub-group and meta-regression analyses were performed to examine potential sources of *** meta-analysis included six studies with a total of 623 *** results revealed a significant increase in circulating AGE levels in females with PCOS compared to healthy females(SMD=2.35;95%CI:1.10-3.60;P<0.001).Significant heterogeneity was observed between the studies(I2=96.37%;P<0.001),indicating the presence of several factors influencing the ***-group analyses based on body mass index,age,and homeostatic model assessment for insulin resistance indicated differential effects of AGEs on specific *** systematic review and meta-analysis support the association between elevated AGE levels and PCOS,thereby suggesting the potential role of AGEs as biomarkers in PCOS.

关键词： Polycystic ovary syndrome PCOS Advanced glycation end products AGEs Biomarker Meta-analysis

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城市道路交通噪声频谱及其对隔声评价中频谱修正量的影响

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振动与冲击 2024年第19期43卷 287-297页

作者：蔡阳生陈智慧 akram A N A 袁旻忞福建理工大学建筑与城乡规划学院福州350118 福建理工大学土木工程学院福州350118 国家环境保护道路交通噪声控制工程技术中心北京100088 交通运输部公路科学研究院北京100088

现行隔声评价标准中交通噪声频谱修正量参考的是20世纪80年代北欧测量得到的交通噪声数据。为了研究C_(tr)修正量是否适用于评价建筑外窗对新时代城市道路交通噪声的隔声性能,对多种城市交通道路进行噪声监测,根据测量结果提出一组新的... 详细信息

现行隔声评价标准中交通噪声频谱修正量参考的是20世纪80年代北欧测量得到的交通噪声数据。为了研究C_(tr)修正量是否适用于评价建筑外窗对新时代城市道路交通噪声的隔声性能,对多种城市交通道路进行噪声监测,根据测量结果提出一组新的交通噪声频谱修正曲线C_(A),计算11种常见外窗构造在不同频率范围内的计权隔声量,并对比分析不同频谱修正量声压级频谱的差异性。结果表明:不同城市道路交通噪声频谱都具有低频声压级高、中频平稳、高频下降的相似特点;当今的城市道路交通噪声低频能量远低于C_(tr)所参考的频谱,其能量频谱分布更接近于C_(100~3150);对比分析11组外窗的交通噪声频谱修正量C_(A)与现行标准的频谱修正量的差异,C_(A)均落于C和C_(tr)参考频谱之间的范围内;C_(A)与C、C_(tr)参考频谱的相关系数R2的值均>0.9且高于C与C_(tr)的相关性,因此C_(A)对城市道路交通噪声频谱修正具有更好的适用性与代表性,研究结果可为临街住宅的隔声降噪工程提供数据参考。

关键词：城市道路交通噪声隔声频谱修正量外窗

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Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations

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Genes & Diseases 2024年第3期11卷 136-139页

作者： Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad akram Khan Chujiang Xu Jingxing Dai Jun Ouyang Guangdong Provincial Key Laboratory of Medical Biomechanics&National Key Discipline of Human Anatomy Schoolof BasicMedical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Laboratory Medicine Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Breast Surgery Guangxi Medical University Cancer HospitalNanningGuangxi 530000China Department of Veterinary Pathology Faculty of Veterinary and Animal SciencesPMAS Arid Agriculture UniversityRawalpindi 46300Pakistan Department of Orthopedics TCM-Integrated HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China

Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout ***,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.

关键词： alterations injuries massive

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俾路支褐煤有机结构特征及大分子模型构建

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洁净煤技术 2024年第6期30卷 75-84页

作者：任媛莫文龙马亚亚郭佳魏贤勇 akram Naeem 新疆大学化工学院省部共建碳基能源资源化学与利用国家重点实验室新疆维吾尔自治区乌鲁木齐830046 新疆大学化工学院煤炭清洁转化与化工过程新疆维吾尔自治区重点实验室新疆维吾尔自治区乌鲁木齐830046 新疆能源(集团)有限公司新疆吾尔自治区乌鲁木齐830000 中国矿业大学煤炭加工与高效利用教育部重点实验室江苏徐州221116 明哈吉大学拉合尔分校化工学院巴基斯坦旁遮普拉合尔54000

以巴基斯坦俾路支褐煤(BL)为研究对象,由元素分析得出BL化学式为C_(167)H_(130)O_(53)N_(2)S。经X射线光电子能谱(XPS)分析BL有机结构中氧、氮和硫元素存在形式。利用傅里叶变换红外光谱(FT-IR)研究BL有机结构中主要官能团特征,-CH和-CH... 详细信息

以巴基斯坦俾路支褐煤(BL)为研究对象,由元素分析得出BL化学式为C_(167)H_(130)O_(53)N_(2)S。经X射线光电子能谱(XPS)分析BL有机结构中氧、氮和硫元素存在形式。利用傅里叶变换红外光谱(FT-IR)研究BL有机结构中主要官能团特征,-CH和-CH^(2)为BL脂肪族结构中主要官能团。BL中苯环主要取代形式为三取代和四取代。运用核磁共振光谱(^(13)C-NMR)探究BL有机结构碳骨架结构。BL分子结构中,芳香桥碳与周碳之比X_(BP)为0.21,碳主要由芳香碳和脂肪碳2部分构成,其中脂肪碳质量分数53.23%,芳香碳占比41.93%。芳香结构以苯环和萘环为主,氧主要以羧基、羰基、醚氧和酚羟基形式存在,而氮主要以吡咯氮形式存在,硫主要为噻吩。建立BL二维分子结构模型,通过Materials Studio对其进行加氢饱和,构建BL分子模型三维立体结构,进一步优化所得分子模型,空间效果显著,得到能量最低的BL三维结构模型,发现范德华能是BL分子结构稳定的关键因素。通过计算得到的BL模型结构^(13)C NMR谱图与试验所测谱图基本一致,验证了所构建BL结构模型的合理性。

关键词：褐煤分子结构核磁共振碳谱红外光谱 X射线光电子能谱

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反激式开关电源故障非侵入式AI诊断方法研究

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电子测量与仪器学报 2024年

作者：唐圣学谭立强李从宏严金晶 Muhammad Ehtsham akram 赵金泽河北工业大学电气工程学院省部共建电工装备可靠性与智能化国家重点实验室南京工业职业技术大学

将人工智能技术应用到故障诊断领域可以实现电力设备的自动化、智能化诊断，提高诊断精度和效率。以单输入多输出的反激式开关电源为例，针对其因脆弱元件失效而引起的电路工作性能异常的问题，通过分析不同故障模式的信号特性和可分性... 详细信息

将人工智能技术应用到故障诊断领域可以实现电力设备的自动化、智能化诊断，提高诊断精度和效率。以单输入多输出的反激式开关电源为例，针对其因脆弱元件失效而引起的电路工作性能异常的问题，通过分析不同故障模式的信号特性和可分性，提出了融合输入电流和输出电压信息的非侵入式开关电源故障诊断方法。构建了由时域特征及频带小波包奇异熵特征组成的融合时频域信息的多维特征矢量，建立了故障特征与故障模式之间的映射关系。进而，提出了基于人工智能技术的深度神经网络（DNN）故障诊断方法，实时监测反激式开关电源的运行状态，并通过数据分析及时识别故障位置，对潜在故障进行预警。实验结果表明：本文所提出的方法对单故障和多故障模式均具有良好的诊断效果，诊断准确率可达97.9%，并且，在不同工况下，该方法均可表现出较高的诊断准确率和较强的抗干扰性能。

关键词：人工智能反激式开关电源时域特征小波包奇异熵故障诊断 DNN辨识

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