Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations

作     者：Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad Akram Khan Chujiang Xu Jingxing Dai Jun Ouyang Yuchao Yang;Shutong Wu;Rongmei Qu;Congrong Wang;Jinyang Wang;Asmat Ullah Khan;You Pan;Wenqing Liu;Jinhui Zhu;Muhammad Akram Khan;Chujiang Xu;Jingxing Dai;Jun Ouyang

作者机构：Guangdong Provincial Key Laboratory of Medical Biomechanics&National Key Discipline of Human AnatomySchoolof BasicMedical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Laboratory MedicineNanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of PathologyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Breast SurgeryGuangxi Medical University Cancer HospitalNanningGuangxi 530000China Department of Veterinary PathologyFaculty of Veterinary and Animal SciencesPMAS Arid Agriculture UniversityRawalpindi 46300Pakistan Department of OrthopedicsTCM-Integrated HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第3期

页      面：136-139页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080202[工学-机械电子工程] 0802[工学-机械工程] 0836[工学-生物工程] 

基　　金：supported bythe National Key R&D Program of China(No.2022YFF1202603) the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110440) the National Natural Science Foundation of China(No.82002779) the Guangxi Provincial Natural Science Foundation of China(No.2019GXNSFAA245083) the China Postdoctoral Science Foundation(No.2022M710853) the President's Foundation of the TCM-integrated Hospital of Southern Medical University(No.1202103001) 

主　　题：alterations injuries massive 

摘      要：Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout ***,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.