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Ⅲ型效应子GALA对青枯菌在两种寄主植物上致病性的影响（英文）

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微生物学报 2018年第1期58卷 131-141页

作者：陈立李建科成田雅敏大西浩平木厂章范曳地康史陕西师范大学食品工程与营养科学学院陕西西安710119 高知大学分子遗传研究中心高知大学植物病理研究所

【目的】研究III型效应子GALAs对青枯菌OE1-1在不同寄主植物致病性上的影响。【方法】构建青枯菌OE1-1的多种GALA缺失突变体,通过根切和叶片注射等方法研究GALAs对青枯菌OE1-1致病力和细胞内增殖能力的影响。【结果】GALA多基因缺失突... 详细信息

【目的】研究III型效应子GALAs对青枯菌OE1-1在不同寄主植物致病性上的影响。【方法】构建青枯菌OE1-1的多种GALA缺失突变体,通过根切和叶片注射等方法研究GALAs对青枯菌OE1-1致病力和细胞内增殖能力的影响。【结果】GALA多基因缺失突变体对寄主烟草的致病力减弱,在烟草体内细菌繁殖能力较野生型明显降低,但在寄主番茄上不影响其致病性。【结论】GALA效应子对青枯菌OE1-1在烟草植株致病性上展现协同作用。

关键词：青枯菌OE1-1 GALAs 致病性细菌增殖烟草番茄

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Risk Analysis of the Economic Benefits of Ochroma pyramidale:A Case Study of Forest Planting in Brazil

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Journal of Agricultural Science and Technology(B) 2018年第7期8卷 444-453页

作者： Ricardo Hideaki miyajima Vitória Castro Santos Barreto Paulo Andréde Oliveira Gislaine Cristina Batistela Danilo Simoes Department of Forestry Science Sao Paulo State University(Unesp)School of AgricultureBotucatuSao Paulo 18610-307Brazil Department of Agribusiness State Center for Technological Education Paula SouzaBotucatuSao Paulo 18606-855Brazil Department of Production Engineering Sao Paulo State University(Unesp)Campus of ItapevaSao Paulo 18409-010Brazil

The forest investment projects,analyzed through the application of simulation techniques,allow measuring more accurately the benefits or losses,considering the systemic uncertainties related to forest *** this perspective,the objective of this study was to identify the relative importance of sources of uncertainties in determining the net present value(NPV)of planting of Ochroma pyramidale on a forested property located in the state of S?o Paulo,***,it assigns probability distributions to the parameters with uncertainties and applies the Monte Carlo technique to obtain the stochastic behavior of the NPV,of the modified internal rate of return(MIRR)and the profitability index(PI).The probabilistic results of the quantitative methods analyzed allowed us to conclude that for the planting ***,with 5-year cutting age,indicated economic *** addition,there is a probability that 84.6%of the project will add economic value to the invested capital.

关键词： Balsa wood forest plantation forest management net present value Monte Carlo

Effect of Universal Primers on the Tensile Bond Strength between Zirconia and Resin Composites

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材料科学与工程（中英文B版） 2021年第1期11卷 1-7页

作者： akinori Ohno Mizuki Nagata Hiroaki Kobayashi Hiroaki Yamaguchi Katsura Ohashi Kaori Aoki Tomotaro Nihei Katsuhiko Kimoto Department of Oral Interdisciplinary Medicine Prosthodontics&Oral Implantology Graduate School of DentistryKanagawa Dental University82 Inaoka-choYokosukaKanagawa 238-8580Japan Division of Clinical Biomaterials Department of Oral ScienceGraduate School of DentistryKanagawa Dental University82 Inaoka-choYokosukaKanagawa 238-8580Japan

This study aimed to evaluate the effects of universal primers on the tensile bond strength between zirconia and resin *** specimens were divided into five groups based on the surface treatment with the following primers:MP(Monobond Plus),SU(ScotchBond Universal),AZ(AZ Primer),BM(Beauty bond Multi),and BL(Bondmer Lightless).After priming,stainless steel rods were bonded to the zirconia specimens with composite *** tensile bond strength test was performed:stored at room temperature for 1 day;stored in distilled water at 37°C for 7 days;and underwent thermal *** BL group demonstrated a significantly higher tensile bond strength than other groups when stored at room temperature for 1 day(p<0.05).The primer that acted via chemical polymerization appeared to be most effective in improving the bond strength between the two materials in this study.

关键词： Universal primer zirconia composite resin bond strength.

Phase Ⅰ trial of combination chemotherapy with gemcitabine, cisplatin, and S-1 in patients with advanced biliary tract cancer

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World Journal of Gastroenterology 2015年第19期21卷 5979-5984页

作者： akinori Watanabe Mitsuhiro Kida Shiro Miyazawa Tomohisa Iwai Kosuke Okuwaki Toru Kaneko Hiroshi Yamauchi Miyoko Takezawa Hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

AIM: To evaluate the dose-limiting toxicities(DLTs)and determine the maximum-tolerated dose(MTD) and recommended dose(RD) of combination chemotherapy with gemcitabine, cisplatin and S-1 which is an oral fluoropyrimidine pro-drug in patients with advanced biliary tract ***: Patients with histologically or cytologically confirmed unresectable or recurrent biliary tract cancer were enrolled. The planned dose levels of gemcitabine(mg/m2), cisplatin(mg/m2), and S-1(mg/m2 per day) were as follows: level-1, 800/20/60;level 0, 800/25/60; level 1, 1000/25/60; and level 2,1000/25/80. In each cycle, gemcitabine and cisplatin were administered intravenously on days 1 and 15,and S-1 was administered orally twice daily on days 1to 7 and days 15 to 21, every 4 ***: Twelve patients were enrolled, and level0 was chosen as the starting dose. None of the first three patients had DLTs at level 0, and the dose was escalated to level 1. One of six patients had DLTs(grade 4 febrile neutropenia, leucopenia, and neutropenia; grade 3 thrombocytopenia) at level *** then proceeded to level 2. None of three patients had DLTs during the first cycle. Although the MTD was not determined, level 2 was designated at the RD for a subsequent phase Ⅱ ***: The RD was defined as gemcitabine1000 mg/m2(days 1, 15), cisplatin 25 mg/m2(days1, 15), and S-1 80 mg/m2 per day(days 1-7, 15-21),every 4 weeks. A phase Ⅱ study is planned to evaluate the effectiveness of combination chemotherapy withgemcitabine, cisplatin, and S-1 in advanced biliary tract cancer.

关键词： Gemcitabine Cisplatin, S-1 Advancedbiliary tract cancer

PGK1基因内含子突变可能通过异常剪接导致复发性肌红蛋白尿

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 50-50页

作者： Shirakawa K. Takahashi Y. miyajima H. 刘凯 First Department of Medicine Hainamatsu University School of Medicine 1- 20- 1 Handayama Hamamatsu 4313192 Japan Dr.

A 33- year- old man with mental retardation and recurrent myoglobinuria demonstrated a deficiency in the phosphoglycerate kinase 1 (PGK1) activity of his muscles and erythrocytes. His PGK1 gene had intronic G- to- A substitution 5 nucleotides downstream from the normal exon 7 5′ splice site (IVS7 + 5G>A). This novel mutation results in a frame shift due to the insertion of 52 bp of intron 7 in the mature mRNA by aberrant splicing.

关键词：复发性 PGK1 异常剪接内含子基因

PET用于帕金森病纹状体外小神经胶质细胞活化播散的研究

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中华核医学与分子影像杂志 2017年第3期37卷 192-192页

作者：李梦婷兰晓莉唐军华中科技大学同济医学院附属协和医院核医学科武汉430022 苏州大学附属第二医院核医学科 215004

目的神经炎性胶质反应有助于推进帕金森病（PD）的退行性变过程。然而，小神经胶质细胞发展的模式仍不清楚。方法[11C]DPA713，是一种选择性小神经胶质细胞激活PET示踪剂。本研究应用[11C]DPA713 PET显像量化评估早期PD患者神经炎性变... 详细信息

目的神经炎性胶质反应有助于推进帕金森病（PD）的退行性变过程。然而，小神经胶质细胞发展的模式仍不清楚。方法[11C]DPA713，是一种选择性小神经胶质细胞激活PET示踪剂。本研究应用[11C]DPA713 PET显像量化评估早期PD患者神经炎性变中小神经胶质细胞的激活。选取11个不伴有痴呆的PD患者（Hoehn和Yahr分期为1-2期）进行2次[11C]DPA713PET扫描．2次显像时间相隔1年。通过简化的参考组织模型估算结合潜能（BPND）。应用智能体素和感兴趣区分析比较组间的BPND。结果[11C]DPA713 BPND在帕金森病患者纹状体外的枕叶、颞叶和顶叶皮质摄取呈明显增加，1年后发现在颞叶和枕叶皮质的大脑区域与显像剂结合程度更高。结论本研究结果表明，纹状体外的小神经胶质细胞活化播散是PD早期阶段病理生理变化之一。

关键词：帕金森病(PD) 小神经胶质细胞 [11C]DPA713 正电子发射断层显像术(PET)

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黄斑裂孔术中玻璃体腔内注射吲哚青绿后的视野缺损

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美国医学会眼科杂志（中文版） 2005年第3期17卷 183-183页

作者： Shigeru Kanda akinori Uemura Takehiro Yamashita Hazuki Kita Keita Yamakiri Taiji Sakamoto 李婵（译）蒋幼芹（校）

目的：报道一组患者发现在黄斑裂孔手术中使用吲哚青绿（ICG）辅助内界膜剥离后的视野缺损，并评估视野缺损与使用ICG间的关系。设计：回顾性、非对照性干预的一组病例。参与者：本研究中的39只眼来自38例临床诊断黄斑裂孔患者，自2001... 详细信息

目的：报道一组患者发现在黄斑裂孔手术中使用吲哚青绿（ICG）辅助内界膜剥离后的视野缺损，并评估视野缺损与使用ICG间的关系。设计：回顾性、非对照性干预的一组病例。参与者：本研究中的39只眼来自38例临床诊断黄斑裂孔患者，自2001年1月1日至2002年12月31日问均接受了玻璃体切割术。

关键词：视野缺损黄斑裂孔吲哚青绿玻璃体腔内注射手术中玻璃体切割术患者发现内界膜剥离临床诊断

LARGE-SCALE PURIFICATION OF PROTHORACICOTROPIC HORMONE OF THE SILKWORM (BOMBYX MORI)

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中国科学A辑(英文版) 1980年第8期 1053-1060页

作者：长澤宽道郭郛钟香臣夏邦颖王宗舜仇序佳魏定义陈娥英王敬泽铃木昭宪磯贝彰堀康宏田村三郎石崎宏矩 Institute of Zoology Academia Sinica The University of Tokyo Japan Nagoya University Japan

Prothoracicotropic hormone has been successfully extracted from as many as 2,800,000 silkworm male adult heads and purified partially through an 8-step procedure. Approximately 7μg of the crude preparation ('crude PTTH') shows activity in the debrained Samia pupa test. A further 4-step chromatographic purification of the 'crude PTTH' derived from 100,000 Bombyx heads yields 3.4mg of purified preparation ('highly purified PTTH'), of which 7ng causes adult development in a debrained Samia pupa.

关键词： purified Bombyx silkworm crude purification millions ammonium brains partially dissolved