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Involvement of A5/A7 noradrenergic neurons and B2 serotonergic neurons in nociceptive processing:a fiber photometry study

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Neural Regeneration Research 2022年第4期17卷 881-886页

作者： Shunpei Moriya Akira Yamashita Daiki Masukawa Junichi Sakaguchi Yoko Ikoma Yoshimune Sameshima Yuki Kambe akihiro yamanaka Tomoyuki Kuwaki Department of Physiology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan Department of Molecular Pharmacologyand Neurobiology Yokohama City University Graduate School of MedicineYokohamaJapan Department of Pharmacology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan Research Institute of Environmental Medicine Nagoya UniversityNagoyaJapan

In the central nervous system,the A6 noradrenaline(NA)and the B3 serotonin(5-HT)cell groups are well-recognized players in the descending antinociceptive system,while other NA/5-HT cell groups are not well characterized.A5/A7 NA and B25-HT cells project to the spinal horn and form descending *** recorded G-Ca MP6 green fluorescence signal intensities in the A5/A7 NA and the B25-HT cell groups of awake mice in response to acute tail pinch stimuli,acute heat stimuli,and in the context of a non-noxious control test,using fiber photometry with a calcium imaging *** first introduced G-Ca MP6 in the A5/A7 NA or B25-HT neuronal soma,using transgenic mice carrying the tetracycline-controlled transactivator transgene under the control of either a dopamineβ-hydroxylase or a tryptophan hydroxylase-2 promoters and by the site-specific injection of adeno-associated virus(AAV-Tet O(3 G)-G-Ca MP6).After confirming the specific expression patterns of G-Ca MP6,we recorded G-Ca MP6 green fluorescence signals in these sites in awake mice in response to acute nociceptive stimuli.G-Ca MP6 fluorescence intensity in the A5,A7,and B2 cell groups was rapidly increased in response to acute nociceptive stimuli and soon after,it returned to baseline fluorescence *** was not observed in the non-noxious control *** results indicate that acute nociceptive stimuli rapidly increase the activities of A5/A7 NA or B25-HT neurons but the non-noxious stimuli do *** present study suggests that A5/A7 NA or B25-HT neurons play important roles in nociceptive processing in the central nervous *** suggest that A5/A7/B2 neurons may be new therapeutic *** performed procedures were approved by the Institutional Animal Use Committee of Kagoshima University(MD17105)on February 22,2018.

关键词： A5 NA neurons A7 NA neurons B25-HT neurons DBH-tTA mice fiber photometry G-CaMP6 mCherry monoaminergic signaling nociception TPH-t TA mice

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利用铸坯表层组织控制预防横向裂纹发生

利用铸坯表层组织控制预防横向裂纹发生

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2005中国钢铁年会

作者： Toru KATO Noriaki BABA Yoshiki ITO akihiro yamanaka Corporate R＆D Labs. Sumitomo Metal Industries Ltd. Japan Kashima Steel Works Sumitomo Metal IndustriesLtd.Japan Corporate R＆D Labs. Sumitomo Metal IndustriesLtd.Japan Corporate R＆D Labs. Sumitomo Metal IndustriesLtd.Japan

板坯的表面横裂多发现于连铸的弯曲或矫直处,并与γ-α相变温度区域的热延性有关。许多研究表明,裂纹是由于晶界处片层状铁素体的应变集中所导致的。在传统流程中的弯曲矫直期间,板坯的表面温度主要考虑来避开脆化温度区的。在该研究中... 详细信息

板坯的表面横裂多发现于连铸的弯曲或矫直处,并与γ-α相变温度区域的热延性有关。许多研究表明,裂纹是由于晶界处片层状铁素体的应变集中所导致的。在传统流程中的弯曲矫直期间,板坯的表面温度主要考虑来避开脆化温度区的。在该研究中,提出了一个新的概念:利用铸坯表层微观组织控制来预防横向裂纹。通过板坯表层组织控制（SSC）能够抑制晶界处片层状铁素体的形成,方法有二冷区初期的强冷却和随后的潜热引起的再加热。现场的凝固高温拉伸试验证明,通过微观结构控制可以消除脆性极限。SSC对裂纹敏感性的影响已经通过半工业化连铸机在试验上得到了验证。在浇铸之后进行的是弯曲。在钢坯表面上的慢冷使横裂纹在实验上再现,即传统冷却方式可以产生具有片层状铁素体的正常微观结构。通过表层组织控制（SSC）裂纹是可以预防的。传统连铸也可采用这些操作方法。

关键词：连铸横裂纹二次冷却微观结构热延性析出物低合金钢

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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi Suzuki Kanato Yoshiike Sakura yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

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Influence of image classification accuracy on saliency map estimation

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CAAI Transactions on Intelligence Technology 2018年第3期3卷 140-152页

作者： Taiki Oyama Takao yamanaka Department of Information and Communication Sciences Sophia University 7-1 Kioi-cho Chiyoda-ku Tokyo 102-0094 Japan

Saliency map estimation in computer vision aims to estimate the locations where people gaze in images. Since people tend to look at objects in images, the parameters of the model pre-trained on ImageNet for image classification are useful for the saliency map estimation. However, there is no research on the relationship between the image classification accuracy and the performance of the saliency map estimation. In this study, it is shown that there is a strong correlation between image classification accuracy and saliency map estimation accuracy. The authors also investigated the effective architecture based on multi-scale images and the up-sampling layers to refine the saliencymap resolution. The model achieved the state-of-the-art accuracy on the PASCAL-S, OSIE, and MIT1003 datasets. In the MIT saliency benchmark, the model achieved the best performance in some metrics and competitive results in the other metrics.

关键词：计算机视觉图像处理发展现状计算机技术

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Site effects by generalized inversion technique using strong motion recordings of the 2008 Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 165-184页

作者： Ren Yefei Wen Ruizhi Hiroaki yamanaka Toshihide Kashima Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake Administration Tokyo Institute of Technology Building Research Institute

The generalized inversion of S-wave amplitude spectra from the free-field strong motion recordings of the China National Strong Motion Observation Network System （NSMONS） are used to evaluate the site effects in the Wenchuan area. In this regard, a total of 602 recordings from 96 aftershocks of the Wenchuan earthquake with magnitudes of M3.7-M6.5 were selected as a dataset. These recordings were obtained from 28 stations at a hypocenter distance ranging from 30 km to 150 km. The inversion results have been verified as reliable by comparing the site response at station 62WUD using the Generalized Inversion Technique （GIT） and the Standard Spectral Ratio method （SSR）. For all 28 stations, the site predominant frequency F and the average site amplification in different frequency bands of 1.0-5.0 Hz, 5.0-10.0 Hz and 1.0-10.0 Hz have been calculated based on the inversion results. Compared with the results from the horizontal-to-vertical spectral ratio （HVSR） method, it shows that the HVSR method can reasonably estimate the site predominant frequency but underestimates the site amplification. The linear fitting between the average site amplification for each frequency band and the V20 （the average uppermost-20 m shear wave velocity） shows good correlation. A distance measurement called the asperity distance DAspt is proposed to reasonably characterize the source-to-site distance for large earthquakes. Finally, the inversed site response is used to identify the soil nonlinearity in the main shock and aftershocks of Wenchuan earthquake. In ten of the 28 stations analyzed in the main shock, the soil behaved nonlinearly, where the ground motion level is apparently beyond a threshold ofPGA 〉 300 cm/s^2 or PGV 〉 20 cm/s, and only one station coded 51SFB has evidence of soil nonlinear behavior in the aftershocks.

关键词： generalized inversion technique site effect Wenchuan earthquake soil nonlinearity predominant frequency site amplification

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Isothermal γ →ε phase transformation behavior in a Co-Cr-Mo alloy depending on thermal history during electron beam powder-bed additive manufacturing

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Journal of Materials Science & Technology 2020年第15期47卷 162-170页

作者： Yufan Zhao Yuichiro Koizumi Kenta Aoyagi Kenta yamanaka Akihiko Chiba Department of Materials Processing Graduate School of EngineeringTohoku UniversityAoba-yama 02Aoba-kuSendai980-8579Japan Institute for Materials Research Tohoku University2-1-J KatahiraAoba-kuSendai980-8577Japan

Powder bed fusion with electron beam(PBF-EB),allows Co-Cr-Mo(CCM) implants with patientcustomization to be fabricated with high quality and complex ***,the variability in the properties of PBF-EB-built CCM alloy,mainly due to the lack of understanding of the mechanisms that govern microstructural heterogeneity,brings limitations in extensive *** this study,the microstructural heterogeneity regarding the γ-fcc→ε-hcp phase transformation was *** phase transformation during PBF-EB was analyzed depending on the thermal history that was elucidated by the numerical *** revealed that isothermal γ→ε transformation occurred during the ***,the difference in γ/ε phase distribution was a result of the thermal history determining which method phase transformation was taking place,which can be influenced by the PBF-EB process *** the sample with a low energy input(Earea=2.6 J/mm2),the martensitic transformation was *** the building height increased from the bottom,the e phase fraction *** the other hand,in the sample with a higher energy input(Earea=4.4 J/mm2),the ε phase fo rmed via diffusional-massive transformation and only appea red in a short range of the lower part away from the bottom.

关键词： Powder bed fusion with electron beam Phase transformation Thermal history Numerical simulation

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Duodenal intussusception secondary to ampullary adenoma: A case report

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World Journal of Clinical Cases 2019年第14期7卷 1857-1864页

作者： Masaaki Hirata Yoshiharu Shirakata Kenya yamanaka Department of Surgery Hyogo Prefectural Amagasaki General Medical CenterAmagasakiHyogo 660-0892Japan

BACKGROUND Because the duodenum is fixed onto the retroperitoneum, duodenal intussusception is usually impossible except in cases of malrotational abnormality. Although cases of duodenal intussusception without malrotational abnormalities have been reported, it is unclear whether they constitute true intussusception or simple mucosal prolapse. CASE SUMMARY A 66-year-old woman presented with whole-body edema and malaise. Blood analysis indicated severe anemia and cholestasis. Endoscopic examination revealed a pedunculate polyp on the second part of the duodenum that migrated distally with mucosal elongation. Computed tomography showed duodenal intussusception. A tumor as the lead point and retroperitoneal structure, including the head of the pancreas and fat, invaginated beyond the duodenojejunal flexure. She was diagnosed with ampullary adenoma caused repeated intussusception that reduced spontaneously and underwent pancreaticoduodenectomy. Laparotomy showed tumor prolapse beyond the duodenojejunal flexure without intussusception. There was no evidence of malrotational abnormality. She was discharged with no complications. CONCLUSION We report true duodenal intussusception without malrotational abnormality. This phenomenon was also associated with mucosal prolapse.

关键词： Duodenal intussusception Mucosal prolapse Ampullary adenoma Case report

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Chemically oligomerizable TDP-43:a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis

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Neural Regeneration Research 2022年第11期17卷 2434-2436页

作者： Kohsuke Kanekura Yoshiaki yamanaka Tamami Miyagi Masahiko Kuroda Department of Molecular Pathology Tokyo Medical University

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor *** ALS cases are sporadic,but approximately 5-10%of patients have a f... 详细信息

关键词： sclerosis familial

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Long Gap Discharge Guiding Experiments Using Strongly and Weakly Ionized Plasma Channels for Laser Triggered Lightning

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Plasma Science and Technology 2007年第6期9卷 740-742页

作者： Y.SHIMADA M.YAMAURA C.yamanaka Institute for Laser Technology OsakaJapan

A study to generate longer plasma channel was conucted to improve probability of triggered lightning. To generate the long laser plasma channel, a strongly and a weakly ionized plasma channels were used in series, a scheme called hybrid method. The strongly and the weakly ionized plasma channels were used for triggering an electrical leader and guiding the leader. The electrical leader propagated through the weakly ionized plasma. Then main discharge occurred between the electrodes. It is found that the streamer was accelerated with both the increase in the plasma density and the increase in an ambient electric field close to the plane electrode.

关键词： laser plasma channel lightning velocity of streamer

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Diagnostic tests for hepatitis C: Recent trends in electrochemical immunosensor and genosensor analysis

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World Journal of Gastroenterology 2014年第42期20卷 15476-15491页

作者： Carolina V Uliana Carla S Riccardi Hideko yamanaka Department of Chemistry Federal University of Sao Carlos Department of Physical Chemistry Institute of Chemistry Sao Paulo State University Department of Analytical Chemistry Institute of Chemistry of Araraquara Sao Paulo State University (UNESP)

Hepatitis C is a liver disease that is transmitted through contact with the blood of an infected person. An estimated 150 million individuals worldwide have been chronically infected with the hepatitis C virus(HCV). Hepatitis C shows significant genetic variation in the global population, due to the high rate of viral RNA mutation. There are six variants of the virus(HCV genotypes 1, 2, 3, 4, 5, and 6), with 15 recorded subtypes that vary in prevalence across different regions of the world. A variety of devices are used to diagnose hepatitis C, including HCV antibody test, HCV viral load test, HCV genotype test and liver biopsy. Rapid, inexpensive, sensitive, and robust analytical devices are therefore essential for effective diagnosis and monitoring of disease treatment. This review provides an overview of current electrochemical immunosensor and genosensortechnologies employed in HCV *** are a limited number of publications showing electrochemical biosensors being used for the detection of *** to their simplicity,specificity,and reliability,electrochemical biosensor devices have potential clinical applications in several viral infections.

关键词： Hepatitis C virus Immunosensors Genosensors Electrochemical detection Diagnostic tests

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