Chemically oligomerizable TDP-43:a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis

作     者：Kohsuke Kanekura Yoshiaki Yamanaka Tamami Miyagi Masahiko Kuroda Kohsuke Kanekura;Yoshiaki Yamanaka;Tamami Miyagi;Masahiko Kuroda

作者机构：Department of Molecular PathologyTokyo Medical University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第11期

页      面：2434-2436页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：the JSPS KAKENHI,grant numbers20H03593 (to KK) and 21H02706 (to MK) Takeda Science Foundation (to KK) 

主　　题：sclerosis familial 

摘      要：Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor *** ALS cases are sporadic,but approximately 5-10%of patients have a familial *** date,more than 30 familial ALS-causative genes have been identified (Maurel et al., 2018).